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Molekularbiologie und Genetik

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Uroonkologie
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Zusammenfassung

Durch die Entwicklung von zielgerichteten Medikamenten („targeted drugs“), deren Wirksamkeit auf der Inhibition bedeutsamer biologischer Prozesse der Tumor- u. a. Zellen im Tumor beruht, hat die Kenntnis molekularer Veränderungen solider Tumoren einen neuen Stellenwert im klinischen Alltag erhalten. Darüber hinaus bilden sie die Grundlage der „molekularen Diagnostik“. Diese eignet sich nicht nur zum Nachweis von Tumoren, sondern wird uns in die Lage versetzen, die Prognose und das Therapiensprechen für den einzelnen Patienten individuell zu definieren. Dieses Kapitel gibt eine Übersicht über die molekularen Grundlagen von Krebserkrankungen. Darüber hinaus werden relevante molekularbiologische Techniken dargestellt. Spezifische molekulare Veränderungen und deren klinische Bedeutung sind den einzelnen Organkapiteln zugeordnet.

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Grimm, MO., Wuttig, D., Wullich, B., Schulz, W., Junker, K. (2014). Molekularbiologie und Genetik. In: Rübben, H. (eds) Uroonkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35032-0_7

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  • DOI: https://doi.org/10.1007/978-3-642-35032-0_7

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