Skip to main content

Grundlagen der Prävention

  • Chapter
  • First Online:
Uroonkologie

Zusammenfassung

Die „Reparaturmedizin“ stößt zunehmend an ihre Grenzen. Zum einen wirken sich medizinische Fortschritte in der Behandlung fortgeschrittener Tumoren kaum mehr messbar auf die Lebenserwartung der Gesamtbevölkerung aus. Zum anderen sind mit neuen Therapiekonzepten i. d. R. hohe Kosten verbunden. Durch das Vermeiden von Erkrankungen könnte die Prävention sowohl die krankheitsbedingte als auch die therapiebezogene Morbidität und Mortalität senken. Theoretisch sind Einsparungen bei den Therapiekosten denkbar. Seit Jahren wird daher von Medizin und Politik die Bedeutung der Krebsprävention betont.

Prävention umschreibt generell alle Handlungen, die einer möglichen Gefahr vorbeugen sollen. In diesem Beitrag wird ausschließlich auf die Primärprävention urologischer Malignome eingegangen. Darunter fallen Maßnahmen, die ergriffen werden, ohne dass Symptome oder Beschwerden vorliegen. Da es sich somit um die Behandlung gesunder Menschen handelt, gelten naturgemäß andere Ansprüche in Hinblick auf Risiken und Nebenwirkungen als für die Behandlung erkrankter Personen.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 229.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

Literatur

  • Allen NE, Roddam AW, Sieri S, Boeing H, Jakobsen MU, Overvad K, Tjønneland A, Halkjaer J, Vineis P, Contiero P, Palli D, Tumino R, Mattiello A, Kaaks R, Rohrmann S, Trichopoulou A, Zilis D, Koumantaki Y, Peeters PH, Bueno-de-Mesquita HB, Barricarte A, Rodríguez L, Dorronsoro M, Sánchez MJ, Chirlaque MD, Esquius L, Manjer J, Wallström P, Ljungberg B, Hallmans G, Bingham S, Khaw KT, Boffetta P, Norat T, Mouw T, Riboli E (2009) A prospective analysis of the association between macronutrient intake and renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition. Int J Cancer 125 (4): 982–987

    Article  CAS  PubMed  Google Scholar 

  • Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group (1994) The effect of vitamine E and beta carotene on the incidence of lung cancers and and other cancers in male smokers. N Engl J Med 300: 1029–35

    Google Scholar 

  • Amaral AF, Cantor KP, Silverman DT, Malats N (2010) Selenium and bladder cancer risk: a meta-analysis. Cancer Epidemiol Biomarkers Prev 19 (9): 2407–15

    Article  CAS  PubMed  Google Scholar 

  • Andriole G, Bostwick D, Brawley O, Gomella L, Marberger M, Tindall D, Breed S, Somerville M, Rittmaster R; REDUCE Study Group (2004) Chemoprevention of prostate cancer in men at high risk: rationale and design of the reduction by dutasteride of prostate cancer events (REDUCE) trial. J Urol 172: 1314–7

    Article  CAS  Google Scholar 

  • Andriole GL, Bostwick DG, Brawley OW, Gomella LG, Marberger M, Montorsi F, Pettaway CA, Tammela TL, Teloken C, Tindall DJ, Somerville MC, Wilson TH, Fowler IL, Rittmaster RS; REDUCE Study Group (2010) Effect of dutasteride on the risk of prostate cancer. N Engl J Med 362 (13): 1192–202

    Article  Google Scholar 

  • Becker N (2001) Epidemiologic aspects of cancer prevention in Germany. J Cancer Res Clin Oncol 127 (1): 9–1

    Article  CAS  PubMed  Google Scholar 

  • Boehm K, Borrelli F, Ernst E, Habacher G, Hung SK, Milazzo S, Horneber M (2009) Green tea (Camellia sinensis) for the prevention of cancer. Cochrane Database Syst Rev (3): CD005004

    Google Scholar 

  • Bonovas S, Filioussi K, Sitaras NM (2008) Statin use and the risk of prostate cancer: A metaanalysis of 6 randomized clinical trials and 13 observational studies. Int J Cancer 123 (4): 899–904

    Article  CAS  PubMed  Google Scholar 

  • Brinkman M, Reulen RC, Kellen E, Buntinx F, Zeegers MP (2006) Are men with low selenium levels at increased risk of prostate cancer? Eur J Cancer 42 (15): 2463–71

    Article  CAS  PubMed  Google Scholar 

  • Cao W, Cai L, Rao JY, Pantuck A, Lu ML, Dalbagni G, Reuter V, Scher H, Cordon-Cardo C, Figlin RA, Belldegrun A, Zhang ZF (2005) Tobacco smoking, GSTP1 polymorphism, and bladder carcinoma. Cancer Dec 1; 104 (11): 2400–8

    Google Scholar 

  • Cao W, Cai L, Rao JY, Pantuck A, Lu ML, Dalbagni G, Reuter V, Scher H, Cordon-Cardo C, Figlin RA, Belldegrun A, Zhang ZF (2005) Tobacco smoking, GSTP1 polymorphism, and bladder carcinoma. Cancer 104 (11): 2400–8

    Article  CAS  PubMed  Google Scholar 

  • Chow WH, Devesa SS (2008) Contemporary epidemiology of renal cell cancer. Cancer J 14 (5): 288–301.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Chung M, Lee J, Terasawa T, Lau J, Trikalinos TA. (2011) Vitamin D With or Without Calcium Supplementation for Prevention of Cancer and Fractures: An Updated Meta-analysis for the U.S. Preventive Services Task Force. Ann Intern Med 20; 155 (12): 827–38

    Article  PubMed  Google Scholar 

  • Clark LC, Combs GF Jr, Turnball BW et al. (1996) Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin: a randomized controlled trial. Nutritional Prevention of Cancer Study Group. JAMA 276: 1957–63

    Article  CAS  PubMed  Google Scholar 

  • Cohen JH, Kristal AR, Stanford JL. Fruit and vegetable intakes and prostate cancer risk. J Natl Cancer Inst 2000; 92: 61–8

    Article  CAS  PubMed  Google Scholar 

  • Cross AJ, Peters U, Kirsh VA, Andriole GL, Reding D, Hayes RB, Sinha R (2005) A prospective study of meat and meat mutagens and prostate cancer risk. Cancer Res 65: 11779–84

    Article  CAS  PubMed  Google Scholar 

  • Dennis LK, Snetselaar LG, Smith BJ, Stewart RE, Robbins ME (2004) Problems with the assessment of dietary fat in prostate cancer studies. Am J Epidemiol Sep 1; 160 (5): 436–44

    Google Scholar 

  • deVere White RW, Tsodikov A, Stapp EC, Soares SE, Fujii H, Hackman RM (2010) Effects of a high dose, aglycone-rich soy extract on prostate-specific antigen and serum isoflavone concentrations in men with localized prostate cancer. Nutr Cancer 62 (8): 1036–43

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Djousse L, Schatzkin A, Chibnik LB, D´’Agostino RB, Kreger BE, Ellison RC (2004) Alcohol consumption and the risk of bladder cancer in the Framingham Heart Study. J Natl Cancer Inst Sep 15; 96 (18): 1397–400

    Google Scholar 

  • Engeland A, Tretli S, Bjorge T (2003) Height, body mass index, and prostate cancer: a follow-up of 950000 Norwegian men. Br J Cancer 89 (7): 1237–1242

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Farwell WR, Scranton RE, Lawler EV, Lew RA, Brophy MT, Fiore LD, Gaziano JM (2008) The association between statins and cancer incidence in a veterans population. J Natl Cancer Inst 100 (2): 134–9

    Article  CAS  PubMed  Google Scholar 

  • Ferrucci LM, Sinha R, Ward MH, Graubard BI, Hollenbeck AR, Kilfoy BA, Schatzkin A, Michaud DS, Cross AJ (2010) Meat and components of meat and the risk of bladder cancer in the NIH-AARP Diet and Health Study. Cancer 116 (18): 4345–53

    Article  PubMed Central  PubMed  Google Scholar 

  • Flaherty KT, Fuchs CS, Colditz GA, Stampfer MJ, Speizer FE, Willett WC, Curhan GC (2005) A prospective study of body mass index, hypertension, and smoking and the risk of renal cell carcinoma (United States). Cancer Causes Control 16 (9): 1099–106

    Article  PubMed  Google Scholar 

  • Fraser ML, Lee AH, Binns CW (2005) Lycopene and prostate cancer: emerging evidence. Expert Rev Anticancer Ther 5 (5): 847–54.

    Article  CAS  PubMed  Google Scholar 

  • Freedland SJ, Platz EA, Presti JC Jr, Aronson WJ, Amling CL, Kane CJ, Terris MK (2006) Obesity, serum prostate specific antigen and prostate size: implications for prostate cancer detection. J Urol 175 (2): 500–4

    Article  PubMed  Google Scholar 

  • Friedenreic CM, Thune I (2001) A review of physical activity and prostate cancer risk. Cancer Causes Control 12 (5): 461–75

    Article  Google Scholar 

  • Gaziano JM, Glynn RJ, Christen WG, Kurth T, Belanger C, Macfadyen J, Bubes V, Manson JE, Sesso HD, Buring JE (2009) Vitamins E and C in the Prevention of Prostate and Total Cancer in Men: The Physicians’ Health Study II Randomized Controlled Trial. JAMA 301 (1): 52–62

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Giovannucci E, Liu Y, Stampfer MJ, Willett WC (2006) A prospective study of calcium intake and incident and fatal prostate cancer. Cancer Epidemiol Biomarkers Prev 15 (2): 203–10

    Article  CAS  PubMed  Google Scholar 

  • Gonzalez CA (2010), Riboli E. Diet and cancer prevention: Contributions from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Eur J Cancer 46 (14): 2555–62

    Article  PubMed  Google Scholar 

  • Gonzalez CA (2006) The European Prospective Investigation into Cancer and Nutrition (EPIC). Public Health Nutr 9 (1A): 124–6

    Article  PubMed  Google Scholar 

  • Haseen F, Murray LJ, O’Neill RF, O’Sullivan JM, Cantwell MM (2010) A randomised controlled trial to evaluate the efficacy of a 6 month dietary and physical activity intervention for prostate cancer patients receiving androgen deprivation therapy. Trials 12; 11: 86

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Hotaling JM, Wright JL, Pocobelli G, Bhatti P, Porter MP, White E (2011) Long-term use of supplemental vitamins and minerals does not reduce the risk of urothelial cell carcinoma of the bladder in the VITamins And Lifestyle study. J Urol 185 (4): 1210–5

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Hsieh LJ, Carter HB, Landis PK, Tucker KL, Metter EJ, Newschaffer CJ, Platz EA. (2003) Association of energy intake with prostate cancer in a long-term aging study: Baltimore Longitudinal Study of Aging (United States). Urology 61: 297–301

    Article  PubMed  Google Scholar 

  • Hsu A, Bruno RS, Löhr CV, Taylor AW, Dashwood RH, Bray TM, Ho E (2011) Dietary soy and tea mitigate chronic inflammation and prostate cancer via NFκB pathway in the Noble rat model. J Nutr Biochem 22 (5): 502–10

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Hu J, La Vecchia C, de Groh M, Negri E, Morrison H, Mery L; Canadian Cancer Registries Epidemiology Research Group (2011) Dietary transfatty acids and cancer risk. Eur J Cancer Prev 20 (6): 530–8

    Article  CAS  PubMed  Google Scholar 

  • Ilic D, Forbes KM, Hassed C. (2011) Lycopene for the prevention of prostate cancer. Cochrane Database Syst Rev 11: CD008007

    PubMed  Google Scholar 

  • Jafari S, Etminan M, Afshar K (2009) Nonsteroidal anti-inflammatory drugs and prostate cancer: a systematic review of the literature and meta-analysis. Can Urol Assoc J 3 (4): 323–330

    PubMed Central  PubMed  Google Scholar 

  • Jiang L, Yang KH, Tian JH, Guan QL, Yao N, Cao N, Mi DH, Wu J, Ma B, Yang SH (2010) Efficacy of antioxidant vitamins and selenium supplement in prostate cancer prevention: a meta-analysis of randomized controlled trials. Nutr Cancer 62 (6): 719–27

    Article  CAS  PubMed  Google Scholar 

  • Johnsen NF, Tjønneland A, Thomsen BL, Christensen J, Loft S, Friedenreich C, Key TJ, Allen NE, Lahmann PH, Mejlvig L, Overvad K, Kaaks R, Rohrmann S, Boing H, Misirli G, Trichopoulou A, Zylis D, Tumino R, Pala V, Bueno-de-Mesquita HB, Kiemeney LA, Suárez LR, Gonzalez CA, Sánchez MJ, Huerta JM, Gurrea AB, Manjer J, Wirfält E, Khaw KT, Wareham N, Boffetta P, Egevad L, Rinaldi S, Riboli E (2009) Physical activity and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Int J Cancer 15; 125 (4): 902–8

    Article  CAS  PubMed  Google Scholar 

  • Kellen E, Zeegers M, Paulussen A, Van Dongen M, Buntinx F (2006) Fruit consumption reduces the effect of smoking on bladder cancer risk. The Belgian case control study on bladder cancer. Int J Cancer 118 (10): 2572–8

    Article  CAS  PubMed  Google Scholar 

  • Kirsh VA, Hayes RB, Mayne ST, Chatterjee N, Subar AF, Dixon LB, Albanes D, Andriole GL, Urban DA, Peters U; PLCO Trial (2006) Supplemental and dietary vitamin E, beta-carotene, and vitamin C intakes and prostate cancer risk. J Natl Cancer Inst 98: 245–54

    Article  CAS  PubMed  Google Scholar 

  • Kirsh VA, Mayne ST, Peters U, Chatterjee N, Leitzmann MF, Dixon LB, Urban DA, Crawford ED, Hayes RB (2006) A prospective study of lycopene and tomato product intake and risk of prostate cancer. Cancer Epidemiol Biomarkers Prev 15: 92–8

    Article  CAS  PubMed  Google Scholar 

  • Klein EA, Thompson IM (2004) Update on chemoprevention of prostate cancer. Curr Opin Urol 14: 143–9

    Article  PubMed  Google Scholar 

  • Klein EA, Thompson IM Jr, Tangen CM, Crowley JJ, Lucia MS, Goodman PJ, Minasian LM, Ford LG, Parnes HL, Gaziano JM, Karp DD, Lieber MM, Walther PJ, Klotz L, Parsons JK, Chin JL, Darke AK, Lippman SM, Goodman GE, Meyskens FL Jr, Baker LH (2011) Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA 306 (14): 1549–56

    Article  CAS  PubMed  Google Scholar 

  • Klotz L, Saad F; PCPT-MTOPS Consensus Panel (2007) PCPT, MTOPS and the use of 5ARIs: a Canadian consensus regarding implications for clinical practice. Can Urol Assoc J 1 (1): 17–21

    PubMed Central  PubMed  Google Scholar 

  • Koebnick C, Michaud D, Moore SC, Park Y, Hollenbeck A, Ballard-Barbash R, Schatzkin A, Leitzmann MF (2008) Body mass index, physical activity, and bladder cancer in a large prospective study. Cancer Epidemiol Biomarkers Prev 17 (5): 1214–21

    Article  PubMed  Google Scholar 

  • Laaksonen DE, Laukkanen JA, Niskanen L, Nyyssonen K, Rissanen TH, Voutilainen S, Pukkala E, Hakkarainen A, Salonen JT (2004) Serum linoleic and total polyunsaturated fatty acids in relation to prostate and other cancers: a population-based cohort study. Int J Cancer 111 (3): 444–450

    Article  CAS  PubMed  Google Scholar 

  • Lazarevic B, Boezelijn G, Diep LM, Kvernrod K, Ogren O, Ramberg H, Moen A, Wessel N, Berg RE, Egge-Jacobsen W, Hammarstrom C, Svindland A, Kucuk O, Saatcioglu F, Taskèn KA, Karlsen SJ (2011) Efficacy and safety of short-term genistein intervention in patients with localized prostate cancer prior to radical prostatectomy: a randomized, placebo-controlled, double-blind Phase 2 clinical trial. Nutr Cancer 63 (6): 889–898

    Article  CAS  PubMed  Google Scholar 

  • Lippman SM, Klein EA, Goodman PJ, Lucia MS, Thompson IM, Ford LG, Parnes HL, Minasian LM, Gaziano JM, Hartline JA, Parsons JK, Bearden JD 3rd, Crawford ED, Goodman GE, Claudio J, Winquist E, Cook ED, Karp DD, Walther P, Lieber MM, Kristal AR, Darke AK, Arnold KB, Ganz PA, Santella RM, Albanes D, Taylor PR, Probstfield JL, Jagpal TJ, Crowley JJ, Meyskens FL Jr, Baker LH, Coltman CA Jr (2009) Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA 301: 39–51

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • MacInnis RJ, English DR (2006) Body size and composition and prostate cancer risk: systematic review and meta-regression analysis. Cancer Causes Control 17 (8): 989–1003

    Article  PubMed  Google Scholar 

  • MacLean CH, Newberry SJ, Mojica WA, Khanna P, Issa AM, Suttorp MJ, Lim YW, Traina SB, Hilton L, Garland R, Morton SC (2006) Effects of omega-3 fatty acids on cancer risk: a systematic review. JAMA 295 (4): 403–15

    Article  CAS  PubMed  Google Scholar 

  • Mahmud SM, Franco EL, Aprikian AG (2010) Use of nonsteroidal anti-inflammatory drugs and prostate cancer risk: a meta-analysis. Int J Cancer 127 (7): 1680–91

    Article  CAS  PubMed  Google Scholar 

  • Malik A, Afaq F, Sarfaraz S, Adhami VM, Syed DN, Mukhtar H (2005) Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer. Proc Natl Acad Sci USA 102: 14813–8

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Malila N, Virtanen MJ, Virtamo J, Albanes D, Pukkala E (2006) Cancer incidence in a cohort of Finnish male smokers. Eur J Cancer Prev 15 (2): 103–7

    Article  PubMed  Google Scholar 

  • Marcus PM, Hayes RB, Vineis P, Garcia-Closas M, Caporaso NE, Autrup H, Branch RA, Brockmoller J, Ishizaki T, Karakaya AE, Ladero JM, Mommsen S, Okkels H, Romkes M, Roots I, Rothman N Cigarette smoking, N-acetyltransferase 2 acetylation status, and bladder cancer risk: a case-series meta-analysis of a gene-environment interaction. Cancer Epidemiol Biomarkers Prev 9 (5): 461–7

    Google Scholar 

  • Meyer F, Galan P, Douville P, Bairati I, Kegle P, Bertrais S, Estaquio C, Hercberg S (2005) Antioxidant vitamin and mineral supplementation and prostate cancer prevention in the SU.VI.MAX trial. Int J Cancer 116: 182–186

    Article  CAS  PubMed  Google Scholar 

  • Moore SC, Chow WH, Schatzkin A, Adams KF, Park Y, Ballard-Barbash R, Hollenbeck A, Leitzmann MF (2008) Physical activity during adulthood and adolescence in relation to renal cell cancer. Am J Epidemiol 15; 168 (2): 149–57

    Article  PubMed Central  PubMed  Google Scholar 

  • Morris JD, Pramanik R, Zhang X, Carey AM, Ragavan N, Martin FL, Muir GH (2005) Selenium- or quercetin-induced retardation of DNA synthesis in primary prostate cells occurs in the presence of a concomitant reduction in androgen-receptor activity. Cancer Lett 2005 (Epub)

    Google Scholar 

  • Moyad MA (2002) Dietary fat reduction to reduce prostate cancer risk: controlled enthusiasm, learning a lesson from breast or other cancers, and the big picture. Urology 59(4 Suppl 1): 51–62

    Article  PubMed  Google Scholar 

  • Moyad MA (2004) Why a statin and/or another proven heart healthy agent should be utilized in the next major cancer chemoprevention trial: part I. Urol Oncol 22: 466–71

    Article  CAS  PubMed  Google Scholar 

  • Moyad MA (2004) Why a statin and/or another proven heart healthy agent should be utilized in the next major cancer chemoprevention trial: part II. Urol Oncol 22: 472–77

    Article  CAS  PubMed  Google Scholar 

  • Myung SK, Kim Y, Ju W, Choi HJ, Bae WK (2010) Effects of antioxidant supplements on cancer prevention: meta-analysis of randomized controlled trials. Ann Oncol 21 (1): 166–79

    Article  PubMed  Google Scholar 

  • Navarro Silvera SA, Rohan TE (2007) Trace elements and cancer risk: a review of the epidemiologic evidence. Cancer Causes Control 18 (1): 7–27

    Article  PubMed  Google Scholar 

  • Newmark HL, Heaney RP (2010) Dairy products and prostate cancer risk. Nutr Cancer 62 (3): 297–9

    Article  CAS  PubMed  Google Scholar 

  • Nicodemus KK, Sweeney C, Folsom AR (2004) Evaluation of dietary, medical and lifestyle risk factors for incident kidney cancer in postmenopausal women. Int J Cancer 1; 108 (1): 115–21

    Article  CAS  PubMed  Google Scholar 

  • Nimptsch K, Rohrmann S, Kaaks R, Linseisen J (2010) Dietary vitamin K intake in relation to cancer incidence and mortality: results from the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg). Am J Clin Nutrit 91 (5): 1348–58

    Article  CAS  PubMed  Google Scholar 

  • Oliveria SA, Lee IM (1997) Is exercise beneficial in the prevention of prostate cancer? Sports Med 23 (5): 271–8

    Article  CAS  PubMed  Google Scholar 

  • Pischon T, Lahmann PH, Boeing H, Tjonneland A, Halkjaer J, Overvad K, Klipstein-Grobusch K, Linseisen J, Becker N, Trichopoulou A, Benetou V, Trichopoulos D, Sieri S, Palli D, Tumino R, Vineis P, Panico S, Monninkhof E, Peeters PH, Bueno-de-Mesquita HB, Buchner FL, Ljungberg B, Hallmans G, Berglund G, Gonzalez CA, Dorronsoro M, Gurrea AB, Navarro C, Martinez C, Quiros JR, Roddam A, Allen N, Bingham S, Khaw KT, Kaaks R, Norat T, Slimani N, Riboli E (2006) Body size and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC). Int J Cancer 118 (3): 728–738

    Article  CAS  PubMed  Google Scholar 

  • Plaza SM, Lamson DW (2005) Vitamin K2 in bone metabolism and osteoporosis. Altern Med Rev 2005; 10: 24–35

    PubMed  Google Scholar 

  • Porter MP, Stanford JL (2005) Obesity and the risk of prostate cancer. Prostate 62 (4): 316–21

    Article  PubMed  Google Scholar 

  • Price D, Stein B, Sieber P, Tutrone R, Bailen J, Goluboff E, Burzon D, Bostwick D, Steiner M (2006) Toremifene for the prevention of prostate cancer in men with high grade prostatic intraepithelial neoplasia: results of a double-blind, placebo controlled, phase IIB clinical trial. J Urol 176 (3): 965–70

    Article  CAS  PubMed  Google Scholar 

  • Qin LQ, Xu JY, Wang PY, Kaneko T, Hoshi K, Sato A (2004) Milk consumption is a risk factor for prostate cancer: meta-analysis of case-control studies. Nutr Cancer 48 (1): 22–27

    Article  PubMed  Google Scholar 

  • Rashidkhani B, Akesson A, Lindblad P, Wolk A (2005) Major dietary patterns and risk of renal cell carcinoma in a prospective cohort of Swedish women. J Nutr 135 (7): 1757–1762

    CAS  PubMed  Google Scholar 

  • Rashidkhani B, Lindblad P, Wolk A (2005) Fruits, vegetables and risk of renal cell carcinoma: a prospective study of Swedish women. Int J Cancer Jan 20; 113 (3): 451–5

    Google Scholar 

  • Rota M, Scotti L, Turati F, Tramacere I, Islami F, Bellocco R, Negri E, Corrao G, Boffetta P, La Vecchia C, Bagnardi V (2011) Alcohol consumption and prostate cancer risk: a meta-analysis of the dose-risk relation. Eur J Cancer Prev Nov 15 [Epub ahead of print]

    Google Scholar 

  • Sarvis JA, Thompson IM (2008) Prostate cancer chemoprevention: update of the prostate cancer prevention trial findings and implications for clinical practice. Curr Oncol Rep 10 (6): 529–32

    Article  CAS  PubMed  Google Scholar 

  • Scardino P (2003) The prevention of prostate cancer – the dilemma continues. N Engl J Med 349: 297–9

    Article  PubMed  Google Scholar 

  • Schmitz-Dräger BJ, Eichholzer M, Beiche B, Ebert T (2001) Nutrition and Prostate Cancer. Urol Int 67: 1–11

    Article  PubMed  Google Scholar 

  • Sommer F, Peters C, Klotz T, Michna H, Schoenenberger A, Engelmann U (2002) Sport und Bewegung in der Prävention urologischer Erkrankungen. Teil I: Uroonkologie und erektile Dysfunktion. Urologe B 42: 297–305

    Article  Google Scholar 

  • Steinmaus CM, Nunez S, Smith AH (2000) Diet and bladder cancer: a meta-analysis of six dietary variables. Am J Epidemiol 151 (7): 693–702

    Article  CAS  PubMed  Google Scholar 

  • Stratton J, Godwin M (2011) The effect of supplemental vitamins and minerals on the development of prostate cancer: a systematic review and meta-analysis. Fam Pract 28 (3): 243–52

    Article  PubMed  Google Scholar 

  • Strom SS, Wang X, Pettaway CA, Logothetis CJ, Yamamura Y, Do KA, Babaian RJ, Troncoso P (2005) Obesity, weight gain, and risk of biochemical failure among prostate cancer patients following prostatectomy. Clin Cancer Res 11: 6889–94

    Article  CAS  PubMed  Google Scholar 

  • Tavani A, Bertuccio P, Bosetti C, Talamini R, Negri E, Franceschi S, Montella M, La Vecchia C (2005) Dietary intake of calcium, vitamin D, phosphorus and the risk of prostate cancer. Eur Urol 48: 27–33

    Article  CAS  PubMed  Google Scholar 

  • Taylor ML, Wells BJ, Smolak MJ (2008) Statins and cancer: a meta-analysis of case-control studies. Eur J Cancer Prev 17 (3): 259–68

    Article  PubMed  Google Scholar 

  • Thomas LG (2005) Increased risk of cardiovascular events with coxibs and NSAIDs. Lancet; 365: 1538–9

    Article  CAS  PubMed  Google Scholar 

  • Thompson IM, Goodman PJ, Tangen CM, Lucia MS, Miller GJ, Ford LG, Lieber MM, Cespedes RD, Atkins JN, Lippman SM, Carlin SM, Ryan A, Szczepanek CM, Crowley JJ, Coltman CA Jr (2003) The influence of finasteride on the development of prostate cancer. N Engl J Med 349: 215–24

    Article  CAS  PubMed  Google Scholar 

  • van Adelsberg J, Gann P, Ko AT, Damber JE, Logothetis C, Marberger M, Schmitz-Drager BJ, Tubaro A, Harms CJ, Roehrborn C (2007) The VIOXX in Prostate Cancer Prevention study: cardiovascular events observed in the rofecoxib 25 mg and placebo treatment groups. Curr Med Res Opin 23 (9): 2063–70

    Article  CAS  PubMed  Google Scholar 

  • van Dijk BA, Schouten LJ, Kiemeney LA, Goldbohm RA, van den Brandt PA (2005) Vegetable and fruit consumption and risk of renal cell carcinoma: results from the Netherlands cohort study. Int J Cancer 117 (4): 648–54

    Article  CAS  PubMed  Google Scholar 

  • Wannamethee SG, Shaper AG, Walker M (2001) Physical activity and risk of cancer in middle-aged men. Br J Cancer 85 (9): 1311–6

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Watters JL, Gail MH, Weinstein SJ, Virtamo J, Albanes D (2009) Associations between alpha-tocopherol, beta-carotene, and retinol and prostate cancer survival. Cancer Res 1; 69 (9): 3833–41

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Wilt TJ, Macdonald R, Hagerty K, Schellhammer P, Tacklind J, Somerfield MR, Kramer BS (2010) 5-α-Reductase inhibitors for prostate cancer chemoprevention: an updated Cochrane systematic review. BJU Int 106 (10): 1444–51

    Article  CAS  PubMed  Google Scholar 

  • Wright ME, Bowen P, Virtamo J, Albanes D, Gann PH (2011) Estimated phytanic acid intake and prostate cancer risk: A prospective cohort study. Int J Cancer 28 [Epub ahead of print]

    Google Scholar 

  • Zeegers MP, Volovics A, Dorant E, Goldbohm RA, van den Brandt PA (2001) Alcohol consumption and bladder cancer risk: results from The Netherlands Cohort Study. Am J Epidemiol 153 (1): 38–41

    Article  CAS  PubMed  Google Scholar 

  • Zeegers MP, Goldbohm RA, Bode P, van den Brandt PA (2002) Prediagnostic toenail selenium and risk of bladder cancer. Cancer Epidemiol Biomarkers Prev 11 (11): 1292–7

    CAS  PubMed  Google Scholar 

  • Zeegers MP, Kellen E, Buntinx F, van den Brandt PA (2004) The association between smoking, beverage consumption, diet and bladder cancer: a systematic literature review. World J Urol 21 (6): 392–401

    Article  PubMed  Google Scholar 

  • Zeegers MP, Dirx MJ, van den Brandt PA (2005) Physical activity and the risk of prostate cancer in the Netherlands cohort study, results after 9.3 years of follow-up. Cancer Epidemiol Biomarkers Prev 14 (6): 1490–5

    Article  PubMed  Google Scholar 

  • Zhang J, Kesteloot H (2005) Milk consumption in relation to incidence of prostate, breast, colon, and rectal cancers: is there an independent effect? Nutr Cancer 53 (1): 65–72

    Article  PubMed  Google Scholar 

  • Zheng J, Yang B, Huang T, Yu Y, Yang J, Li D (2011) Green tea and black tea consumption and prostate cancer risk: an exploratory meta-analysis of observational studies. Nutr Cancer 63 (5): 663–72

    Article  CAS  PubMed  Google Scholar 

  • Zu K, Giovannucci E (2009) Smoking and aggressive prostate cancer: a review of the epidemiologic evidence. Cancer Causes Control 20 (10): 1799–810

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Schmitz-Dräger, B., Lümmen, G. (2014). Grundlagen der Prävention. In: Rübben, H. (eds) Uroonkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35032-0_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-35032-0_11

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-35031-3

  • Online ISBN: 978-3-642-35032-0

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics