Skip to main content

“Gender-Specific Drug Prescription in Germany” Results from Prescriptions Analyses

  • Chapter
  • First Online:
Sex and Gender Differences in Pharmacology

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 214))

Abstract

There are still considerable differences in the medication supply for men and women. While the prescription volumes for both men and women have, for some time, been similar or have even risen for the men, there are still characteristic differences between the sexes when it comes to the prescription of certain indication groups. Women are still prescribed clearly more drugs in the field of psychotropic medication, especially antidepressants, hypnotic drugs, and tranquilisers. As the American Beers criteria for quite some time now and, more recently, the German PRISCUS list have shown, the effects of such drugs are potentially dangerous, particularly for older women. The known adverse effects are, apart from dependence problems, restricted cognitive capacities, insecure or instable walking, and badly healing wounds from falling accidents that are followed by patient’s nursing care dependency. In secondary prophylaxis after acute myocardial infarction, the characteristic prescription features of the various medicinal products that are used for both men and women (such as platelet aggregation inhibitors, beta-receptor blockers, ACE-inhibitors, statins) have become similar; women’s still higher mortality risk appears to go back to the fact that too much time is spent before proper hospital treatment commences. In general, more attention should be paid to the right medication, the right length of treatment, and the right dosage of the medication prescribed to women; the evidence concerning women’s supply of medicinal products should also be improved.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 259.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

DDD:

Defined daily doses

SSRI:

Selective serotonin reuptake inhibitor

NSMRI:

Non-selective monoamine reuptake inhibitor

ATC Code:

Anatomical therapeutic chemical classification system (WHO)

ICD-10:

International statistical classification of diseases and related health problems (WHO)

Rx:

Prescription only drug

List of references

  • Coca V, Nink K (2011) Arzneiverordnungen nach alter und geschlecht. In: Schwabe U, Paffrath D (eds) Arzneiverordnungs-Report 2011. Springer, Heidelberg, Berlin

    Google Scholar 

  • Cumming RG, Le Couteur DG (2003) Benzodiazepines and risk of hip fractures in older people: a review of the evidence. CNS Drugs 7:825–837

    Article  Google Scholar 

  • Fick DM, Cooper JW, Wade WE, Waller JL, Maclean JR, Beers MH (2003) Updating the Beers criteria for potentially inappropriate medication use in older adults: results of a US consensus panel of experts. Arch Intern Med 163:2716–2724

    Article  PubMed  Google Scholar 

  • Franke A, Elsesser K, Sitzler F, Algermissen G, Kötter S (1998) Gesundheit und Abhängigkeit bei Frauen: Eine salutogenetische Verlaufsstudie. Runge, Cloppenburg

    Google Scholar 

  • Glaeske G (2002) Geschlechtsspezifische Inanspruchnahme des Versorgungssystems. In: Hurrelmann K, Kolip P (eds) Geschlecht, Gesundheit und Krankheit. Männer und Frauen im Vergleich. Huber, Bern

    Google Scholar 

  • Glaeske G (2011) Psychotrope und andere Arzneimittel mit Abgängigkeitspotenzial. In: Deutsche Hauptstelle für Suchtfragen (DHS) (ed) Jahrbuch Sucht 2011. Geesthacht, Neuland, pp 165–188

    Google Scholar 

  • Glaeske G, Janhsen K (2006) GEK-Arzneimittelreport 2006. Asgard, St. Augustin

    Google Scholar 

  • Glaeske G, Schicktanz C (2011) BARMER GEK Arzneimittelreport 2011. Asgard, St. Augustin

    Google Scholar 

  • Herings RM, Stricker BH, de Boer A, Bakker A, Sturmans F (1995) Benzodiazepines and the risk of falling leading to femur fractures. Dosage more important than elimination half-life. Arch Intern Med 155:1801–1807

    Article  PubMed  CAS  Google Scholar 

  • Hippisley-Cox J, Pringle M, Crown N, Meal A, Wynn A (2001) Sex inequalities in ischaemic heart disease in general practice: cross sectional survey. BMJ 322:1–5

    Article  Google Scholar 

  • Hoffmann F, Glaeske G (2006) Neugebrauch von Benzodiazepinen und das Risiko einer proximaler Femurfrakturen. Eine case-crossover studie. Z Gerontol Geriat 39:143–148

    Article  CAS  Google Scholar 

  • Hoffmann F, Glaeske G, Scharffetter W (2006) Zunehmender Hypnotikagebrauch auf Privatrezepten in Deutschland. Sucht 52:360–366

    Google Scholar 

  • Hoffmann F, Scharffetter W, Glaeske G (2009) Verbrauch von Zolpidem und Zopiclone auf Privatrezepten zwischen 1993 und 2007. Nervenarzt 80:578–583

    Article  PubMed  CAS  Google Scholar 

  • Hoffmann F, Hies M, Glaeske G (2010) Regional variations of private prescriptions for non-benzodiazepine hypnotics zolpidem and zopiclone in Germany. Pharmacoepidemiol Drug Saf 19:1071–1077

    Article  PubMed  Google Scholar 

  • Holt S, Schmiedl S, Thürmann PA (2010) Potenziell inadäquate Medikation für ältere Menschen: Die PRISCUS-Liste. Dtsch Arztebl Int 107:543–551

    PubMed  Google Scholar 

  • Leipzig RM, Cumming RG, Tinetti ME (1999) Drugs and falls in older people: a systematic review and meta-analysis: I. Psychotropic drugs. J Am Geriatr Soc 47:30–39

    PubMed  CAS  Google Scholar 

  • Löwel H, Meisinger C, Heier M et al (2002) Geschlechtsspezifische Trends von plötzlichem Herztod und akutem Herzinfarkt. Ergebnisse des bevölkerungsbasierten KORA/MONICA-Augsburg Herzinfarkt-Registers 1985–1998. Dtsch Med Wochenschr 127:2311–2316

    Article  PubMed  Google Scholar 

  • Madhusoodanan S, Bogunovic OJ (2004) Safety of benzodiazepines in the geriatric population. Expert Opin Drug Saf 3:485–493

    Article  PubMed  CAS  Google Scholar 

  • Mort JR, Aparasu RR (2002) Prescribing of psychotropics in the elderly: why is it so often inappropriate? CNS Drugs 16:99–109

    Article  PubMed  Google Scholar 

  • Olsson G, Wikstrand J, Warnold I, Manger CV, McBoyle D, Herlitz J, Hjalmarson A, Sonneblick EH (1992) Metoprolol-induced reduction in postinfarction mortality: pooled results from five double-blind randomized trials. Eur Heart J 13:28–32

    PubMed  CAS  Google Scholar 

  • Ray WA, Griffin MR, Downey W (1989) Benzodiazepines of long and short elimination half-life and the risk of hip fracture. JAMA 262:3303–3307

    Article  PubMed  CAS  Google Scholar 

  • Seeland U, Regitz-Zagrosek V (2012) Sex and gender differences in cardiovascular drug therapy. In: Regitz-Zagrosek V (ed) Sex and gender differences in pharmacology. Springer, Heidelberg

    Google Scholar 

  • Statistisches Bundesamt (2012) DeSTATIS. Lebenserwartung in Deutschland. https.//www.destatis.de

    Google Scholar 

  • Theres H, Maier B, Matteucci Gothe R et al (2004) Influence of gender on treatment and short-term mortality of patients with acute myocardial infarction in Berlin. Z Kardiol 93:954–963

    Article  PubMed  CAS  Google Scholar 

  • Thürmann PA, Haack S, Werner U, Szymanski J, Haase G, Drewelow B, Reimann IR, Hippius M, Siegmund W, May K, Hasford J (2006) Tolerability of beta-blockers metabolized via cytochrome P450 2D6 is sex-dependent. Clin Pharmacol Ther 80:551–553

    Article  PubMed  Google Scholar 

  • Wagner AK, Zhang F, Soumerai SB, Walker AM, Gurwitz JH, Glynn RJ, Ross-Degnan D (2004) Benzodiazepine use and hip fractures in the elderly: who is at greatest risk? Arch Intern Med 164:1567–1572

    Article  PubMed  Google Scholar 

  • Walle T, Byington RP, Furberg CD, McIntyre KM, Vokonas PS (1985) Biologic determinants of propranolol disposition: results from 1308 patients in the beta-blocker heart attack trial. Clin Pharmacol Ther 38:509–518

    Article  PubMed  CAS  Google Scholar 

  • Wang PS, Bohn RL, Glynn RJ, Mogun H, Avorn J (2001) Hazardous benzodiazepine regimens in the elderly: effects of half-life, dosage, and duration on risk of hip fracture. Am J Psychiatry 158:892–898

    PubMed  CAS  Google Scholar 

  • WIdO – Wissenschaftliches Institut der AOK (2012) Ältere Frauen erhalten besonders häufig ungeeignete Arzneimittel. Berlin, 23.März 2012

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Friederike Höfel .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Glaeske, G., Gerdau-Heitmann, C., Höfel, F., Schicktanz, C. (2013). “Gender-Specific Drug Prescription in Germany” Results from Prescriptions Analyses. In: Regitz-Zagrosek, V. (eds) Sex and Gender Differences in Pharmacology. Handbook of Experimental Pharmacology, vol 214. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30726-3_8

Download citation

Publish with us

Policies and ethics