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Das Komplementsystem bei der AMD

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Altersabhängige Makuladegeneration

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Zusammenfassung

Die altersabhängige Makuladegeneration (AMD) ist eine komplexe Erkrankung mit genetischen, umweltbedingten und demographischen Risikofaktoren (► Kap. 3). In den vergangenen Jahren konnte der Nachweis geführt werden, dass entzündliche Prozesse einschließlich einer Dysregulation des Komplementsystems eine wesentliche Rolle bei der Pathogenese der AMD spielen. Polymorphismen in Genen, die für Proteine des Komplementsystems kodieren, beeinflussen die Prädisposition, eine AMD zu entwickeln. Diese Entdeckung trieb weitere Forschungen voran und führte letztlich zur Etablierung des Komplementsystems als Schlüsselkomponente in der Pathogenese der AMD [1].

Ein ähnlicher Text in englischer Sprache wurde in Graefe‘s Archive for Clinical and Experimental Ophthalmology publiziert (Charbel Issa et al. (2011) The Significance of the Complement System for the Pathogenesis of Age-Related Macular Degeneration – Current Evidence and Translation into Clinical Application). Die Arbeit wurde finanziell unterstützt durch die Europäische Kommission, 7. Rahmenprogramm, Marie Curie Intra-European Fellowship (237238); den Wynn-Gund Translational Research Acceleration Program Enhanced Research and Clinical Training Award, National Neurovision Research Institute (NNRI) – Foundation Fighting Blindness (FFB; NNCD-CL-0310.0049-JHU-WG); and the Macular Degeneration Research Award, American Health Assistance Foundation (AHAF; M2010042).

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Authors and Affiliations

  1. Nuffield Laboratory of Ophthalmology, University of Oxford John Radcliffe Hospital, OX3 9DU, Oxford, Großbritannien

    PD Dr. Peter Charbel Issa

  2. Oxford Eye Hospital, The University of Oxford, OX3 9DU, Oxford, Großbritannien

    Prof. Dr. N. V. Chong

  3. Wilmer Eye Institute, Johns Hopkins University, 748 Maumenee Building 600 N. Wolfe Street, 21287-9277, Baltimore, USA

    Prof. Dr. H. P. N. Scholl

Authors
  1. PD Dr. Peter Charbel Issa
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  2. Prof. Dr. N. V. Chong
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  3. Prof. Dr. H. P. N. Scholl
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© 2011 Springer-Verlag Berlin Heidelberg

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Issa, P.C., Chong, N.V., Scholl, H.P.N. (2011). Das Komplementsystem bei der AMD. In: Altersabhängige Makuladegeneration. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-20870-6_4

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  • DOI: https://doi.org/10.1007/978-3-642-20870-6_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-20869-0

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