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Genetik

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Altersabhängige Makuladegeneration

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Zusammenfassung

Erstmalig wurde die altersabhängige Makuladegeneration (AMD) im Jahre 1885 als ein eigenständiges klinisches Krankheitsbild mit altersabhängiger Pigmentverschiebung und atrophischen Veränderungen des zentralen Netzhautbereiches (Makula) beschrieben [28]. Heute gilt die AMD als eine der häufigsten Netzhauterkrankungen in den Industrienationen und als Hauptursache für gesetzlich anerkannte Blindheit [21]. In den letzten Jahrzehnten wurden große Anstrengungen unternommen, die zugrunde liegenden Pathomechanismen der AMD aufzuklären. Zahlreiche klinisch-pathologische und experimentelle Beobachtungen führten zu ersten Konzepten einer AMD-Pathogenese, die darauf abzielen, mögliche Prozesse ausgehend von einer normalen, alternden Netzhaut bis hin zu manifesten Stadien der Erkrankung zu erklären [80].

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  1. Institut für Humangenetik, Universität Regensburg, Franz-Josef-Strauss-Allee 11, 93054, Regensburg

    Dr. Ulrike Friedrich, Dr. L. G. Fritsche & Prof. Dr. B. H. F. Weber

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Friedrich, U., Fritsche, L.G., Weber, B.H.F. (2011). Genetik. In: Altersabhängige Makuladegeneration. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-20870-6_2

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