Zusammenfassung
Die körperlichen Veränderungen, welche die Pubertät ankündigen, beruhen auf der Aktivierung der Hypothalamus-Hypophysen-Ovar-Achse. Man nennt die Aktivierung dieser Funktionskreise Gonadarche. Dieses Kapitel konzentriert sich auf die Ausreifung des hypothalamisch-hypophysär-gonadalen Systems im Allgemeinen und beim weiblichen Geschlecht im Besonderen.
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Literatur
Abitbol J, Abitbol P, Abitbol B (1999) Sex hormones and the female voice. J Voice 13: 424
Andre C, Le Bihan B, Foucaud P (1984) L’echographie pelvienne. Ann Pediatr 31: 177–182
Aubert ML, Pierroz DD, Gruaz NM et al. (1998): Metabolic control of sexual function and growth: role of neuropeptide Y and leptin. Mol Cell Endocrinol 140: 107–113
Aynsley-Green A, Zachmann M, Prader A (1976) Interrelation of the therapeutic effects of growth hormone and testosterone on growth in hypopituitarism. J Pediatr 89: 992
Bayley N, Pinneau S (1952) Tables for predicting adult height from skeletal age. J Ped Endocrinol Metabolism 40: 423
Biro FM, Khoury P, Morrison JA (2006) Influence of obesity on timing of puberty. Int J Androl 29: 272–277
Blum WF, Schweizer R (2003) Insulin-like growth factors and their binding proteins. In: Ranke MB (ed) Diagnostics of endocrine function in children and adolescents. Karger, Basel, p 166
Blumsohn A, Hannon RA, Wrate R et al. (1994) Biochemical markers of bone turnover in girls during puberty. Clin Endocrinol 40: 663
Bonjour JP, Theintz G, Buchs B et al. (1991) Critical years and stages of puberty for spinal and femoral bone mass accumulation during adolescence. J Clin Endocrinol Metab 73: 555
Bourguignon JP, Gérard A, Alvarez Gonzalez ML, Franchimont P (1992) Neuroendocrine mechanisms of onset of puberty. J Clin Invest 90: 1736–1744
Conte FA, Grumbach MM, Kaplan S (1975) A diphasic pattern of gonadotropin secretion in patients with the syndrome of gonadal dysgenesis. J Clin Endocrinol Metab 40: 670
DeMuinck Keizer-Schrama SMPF, Mul D (2001) Trends in pubertal development in Europe. Hum Reprod (Update) 7: 287
de Roux N, Genin E, Carel JC, Matsuda F, Chaussain JL, Milgrom E (2003) Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. Proc Natl Acad Sci USA 100: 10972–10976
Dode C, Hardelin JP (2004) Kallmann syndrome: fibroblast growth factor signaling insufficiency? J Mol Med 82: 725–734
Döring GK (1963) Über die relative Sterilität in den Jahren nach der Menarche. Geburtshilfe Frauenheilkd 23: 30
Faust MS (1977) Somatic development of adolescent girls. Monogr Soc Res Child Dev 42: 1–90
Frederiks AM, van Buuren S, Burgmeijer RJ et al. (2000) Continuing positive secular growth change in the Netherlands 1955-1997. Pediatric Res 47: 316
Frisch R, Revelle R (1970) Height and weight at menarche and a hypothesis of critical body weights and adolescent events. Science 169: 397–399
Gottsch ML, Cunningham MJ, Smith JT et al. (2004) A role for kisspeptins in the regulation of gonadotropin secretion in the mouse. Endocrinology 145: 4073–4077
Greulich W, Pyle S (1959) Radiographic atlas of skeletal development of the hand and wrist, 2nd edn. Stanford University Press, Stanford
Haber HP, Wollmann HA, Ranke MB (1995) Pelvic ultrasonography: early differentiation between isolated premature thelarche and central precocious puberty. Eur J Pediatr 154: 182
Heger S, Mastronardi C, Dissen GA et al. (2007) EAP1, a new transcriptional regulator of the mammalian neuroendocrine reproductive axis. J Clin Invest 117: 2145–2154
Herman-Giddens ME (2006) Recent data on pubertal milestones in United States children: the secular trend toward earlier development. Int J Androl 29: 241–246
Hermann-Giddens ME, Slora EJ, Wassermann RC et al. (1997) Secondary sexual characteristics and menses in young girls seen in office practice: A study from the pediatric research in Office Settings Network. Pediatrics 99: 505
Ivarsson SA, Nilsson KO, Persson PH (1983) Ultrasonography of the pelvic organs in prepuberal and postpuberal girls. Arch Dis Child 58: 352
Jung H, Carmel P, Schwartz MS et al. (1999) Some hypothalamic hamartomas contain transforming growth factor alpha, a puberty-inducing growth factor, but not luteinizing hormone-releasing hormone neurons. J Clin Endocrinol Metab 84: 4695–4701
Juul A, Teilmann G, Scheike T et al. (2006) Pubertal development in Danish children: comparison of recent European and US data. Int J Androl 29: 247–255
Lauritzen CH (1983) Diagnostik und Therapie der Zyklusstörungen während der Pubertät und Adoleszenz. Gynäkologe 16: 32
Lee M (2000) Growth hormone deficiency as the only identifiable cause for primary amenorrhea. J Pediatr Adolec Gynecol 13: 93
Lee PL, Johnson DE, Cousens LS, Fried VA, Williams LT (1989) Purification and complementary DNA cloning of a receptor for basic fibroblast growth factor. Science 245: 57–60
Licinio J, Caglayan S, Ozata M et al. (2004) Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults. Proc Natl Acad Sci USA 101: 4531–4536
Marshall WA, Limongi Y (1976) The skeletal maturity and the prediction of menarche. Ann Hum Biol 3: 235
Marshall WA, Tanner JM (1969) Variations in the pattern of pubertal changes in girls. Arch Dis Child 44: 291
Marshall WA, Tanner JM (1987) Klinische und endokrinologische Merkmale der weiblichen Pubertät. In: Stolecke H, Terruhn V (Hrsg.) Pädiatrische Gynäkologie. Springer, Berlin Heidelberg New York Tokio, S. 83–103
McDowell MA, Brody DJ, Hughes JP (2007) Has age at menarche changed? Results from the National Health and Nutrition Examination Survey (NHANES) 1999-2004. J Adolesc Health 40: 227–231
Metzger DL, Kerrigan JR, Rogol AD (1994) Gonadal steroid hormone regulation of the somatotropic axis during puberty in humans — mechanism of androgen and estrogen action. Trends Endocrinol Metab 5: 290
Ojeda SR, Bilger M (2000) Neuroendocrine regulation of puberty. In: Conn PM, Freeman ME (eds) Neuroendocrinology in physiology and medicine. Humana, Totowa/NJ, p 210
Ojeda SR, Prevot V, Heger S, Lomniczi A, Dziedzic B, Mungenast A (2003) The neurobiology of female puberty. Horm Res 60(Suppl 3): 15–20
Ojeda SR, Roth C, Mungenast A et al. (2006) Neuroendocrine mechanisms controlling female puberty: new approaches, new concepts. Int J Androl 29: 256–263
Ong KK, Ahmed ML, Dunger DB (2006) Lessons from large population studies on timing and tempo of puberty (secular trends and relation to body size): the European trend. Mol Cell Endocrinol 254–255: 8–12
Palmert MR, Hayden DL, Mansfield MJ et al. (2001) The longitudinal study of adrenal maturation during gonadal suppression: evidence that adrenarche is a gradual process. J Clin Endocrinol Metab 86: 4536
Parent AS, Teilmann G, Juul A, Skakkebaek NE, Toppari J, Bourguignon JP (2003) The timing of normal puberty and the age limits of sexual precocity: variations around the world, secular trends, and changes after migration. Endocr Rev 24: 668–693
Plant TM, el Majdoubi M, Durrant AR, Sahu A(1999) Development and organization of the hypophysiotropic hypothalamus driving the pituitary-gonadal axis in the rhesus monkey. Ann Endocrinol 60: 60–66
Porcu E, Venturoli S, Fabbri R et al. (1994) Skeletal maturation and hormonal levels after the menarche. Arch Gynecol Obstet 255: 43
Prader A, Largo RH, Molinari et al. (1989) Physical growth of Swiss children from birth to 20 years of age — first Zürich longitudinal study of growth and development. Helv Paediatr Acta 52 (Suppl): 1
Prader A, Largo RH, Wolf C (1984) Timing of pubertal growth and masturation in the first Zürich longitudinal growth study. Acta Paediatr Hung 25: 155
Rauch F, Schönau E, Woitge H, Remer T, Seibel M (1994) Urinary excretion of hydroxy-pyridinium cross-links of collagen reflects skeletal growth velocity in normal children. Exp Clin Endocrinol 102: 97
Reinken L, van Oost G (1992) Longitudinale Körperentwicklung gesunder Kinder von 0 bis 18 Jahren. Klin Pädiatr 204: 129
Reiter EO, Lee PA (2001) Have the onset and tempo of puberty changed? Arch Pediatr Adolesc Med 155: 988
Roth CL, Ojeda SR (2005) Genes involved in the neuroendocrine control of normal puberty and abnormal puberty of central origin. Ped Endocrinol Reviews 3: 67–76
Salardi S, Orsini LF, Cacciari E, Bovicelli L, Tassoni P, Reggiani A (1985) Pelvic ultrasonography in premenarcheal girls: relation to puberty and sex hormone concentrations. Arch Dis Child 60: 120–125
Schwanzel-Fukuda M, Crossin KL, Pfaff DW, Bouloux PM, Hardelin JP, Petit C (1996) Migration of luteinizing hormone-releasing hormone (LHRH) neurons in early human embryos. J Comp Neurol 366: 547–557
Seminara SB, Messager S, Chatzidaki EE et al. (2003) The GPR54 gene as a regulator of puberty. N Engl J Med 349: 1614–1627
Shahab M, Mastronardi C, Seminara SB, Crowley WF, Ojeda SR, Plant TM (2005) Increased hypothalamic GPR54 signaling: a potential mechanism for initiation of puberty in primates. Proc Natl Acad Sci USA 102: 2129–2134
Shaw NJ, Dutton J, Fraser WD, Smith CS (1995) Urinary pyridinoline and deoxypyridinoline excretion in children. Clin Endocrinol 42: 607
Spratt DI, Crowley WF Jr (1988) Pituitary and gonadal responsiveness is enhanced during GnRH-induced puberty. Am J Physiol 254: E652–657
Suter KJ, Pohl CR, Plant TM (1999) Indirect assessment of pulsatile gonadotropin-releasing hormone release in agonadal prepubertal rhesus monkeys (Macaca mulatta). J Endocrinol 160: 35–41
Tanner J (1962) Growth at adolescence. Blackwell, Oxford
Tanner JM, Eveleth PB (1975) Variability between populations in growth and development at puberty. In: Berenberg SR (ed) Puberty, biologic and psychosocial components. Stenfert Kreose, Leiden, pp 256–273
Tanner JM, Whitehouse RH, Hughes PCR, Carter BS (1976) Relative importance of growth hormone and sex steroids for the growth at puberty of trunk length, limb length and muscle in growth hormone-deficient children. J Pediatr 89: 1000
Tanner JM, Whitehouse RH, Marshall WA (1975a) Assessment of skeletal maturity and prediction of adult height (TW 2 method). Academic Press, London New York
Tanner JM, Whitehouse RH, Marshall WA et al. (1975 b) Prediction of adult height from height, bone age, and occurrence of menarche, at ages 4 to 16 with allowance for midparent height. Arch Dis Child 50: 14
Teles MG, Bianco SD, Brito VN et al. (2008) A GPR54-activating mutation in a patient with central precocious puberty. N Engl J Med 358: 709–715
Terasawa E (1995) Control of luteinizing hormone-releasing hormone pulse generation in nonhuman primates. Cell Mol Neurobiol 15: 141–164
Teoh ES, Ratnam SS, Wong PC (1987) (eds) Ovulation and early pregnancy. Parthenon, Casterton Hall Carnforth
Weber A, Clark AJ, Perry LA (1997) Diminished adrenal androgen secretion in familial glucocorticoid deficiency implicates a significant role for ACTH in the induction of adrenarche. Clin Endocrinol 46: 431
Wildt L, Marshall G, Knobil E (1980) Experimental induction of puberty in the infantile female rhesus monkey. Science 207: 1373–1375
Wray S (2002) Development of gonadotropin-releasing hormone-1 neurons. Front Neuroendocrinol 23: 292–316
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Roth, C., Hiort, O., Jung, H. (2009). Endokrinologie der Kindheit, der Pubertät und der Adoleszenz. In: Leidenberger, F., Strowitzki, T., Ortmann, O. (eds) Klinische Endokrinologie für Frauenärzte. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-89760-6_4
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