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Primäre Ovarinsuffizienz

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Klinische Endokrinologie für Frauenärzte

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Zusammenfassung

Unter einer primären Ovarinsuffizienz versteht man eine Störung der Ovarfunktion auf der Ebene des Ovars selbst, deren endokrines Hauptmerkmal erhöhte Spiegel des follikelstimulierenden Hormons (FSH) sind (hypergonadotroper Hypogonadismus). Einen physiologischen hypergonadotropen Hypogonadismus stellt die Postmenopause dar: In dieser Phase sind die überhöhten FSH-Spiegel Ausdruck der negativen Rückkopplungsmechanismen zwischen Hypothalamus-Hypophyse einerseits und Ovar andererseits. Sie spiegeln das Fehlen suppressiv wirkender ovarieller Substanzen wider, nämlich der Sexualsteroide östradiol und Progesteron sowie des Peptidhormons Inhibin B (▸ Kap. 5.3). Hypergonadotrope FSH-Spiegel illustrieren also den verstärkten, letztlich frustranen Versuch der Hypothalamus-Hypophysen-Achse, durch verstärkte Synthese und Sekretion von Gonadotropinen nicht mehr existente oder nicht mehr stimulierbare Follikel zur Reifung zu bringen bzw. in die endokrine Leistung des Ovars einzugreifen.

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Authors and Affiliations

  1. Endokrinologikum Hamburg Zentrum für Hormon- und Stoffwechselerkrankungen, Reproduktionsmedizin und Gynäkologische Endokrinologie, Lornsenstraße 4-6, 22767, Hamburg

    Michael Ludwig Prof. Dr. med.

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  1. Michael Ludwig Prof. Dr. med.
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  1. Lokstedter Damm 15, 22453, Hamburg

    Freimut Leidenberger

  2. Abt. für Gynäkologische Endokrinologie und Fertilitätsstörungen, Universitätsklinikum Heidelberg, Voßstraße 9, 69115, Heidelberg

    Thomas Strowitzki

  3. Klinik für Frauenheilkunde und Geburtshilfe der Universität Regensburg am Caritas-Krankenhaus St. Josef, Landshuter Straße 65, 93053, Regensburg

    Olaf Ortmann

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© 2009 Springer Medizin Verlag Heidelberg

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Ludwig, M. (2009). Primäre Ovarinsuffizienz. In: Leidenberger, F., Strowitzki, T., Ortmann, O. (eds) Klinische Endokrinologie für Frauenärzte. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-89760-6_13

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  • DOI: https://doi.org/10.1007/978-3-540-89760-6_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-89759-0

  • Online ISBN: 978-3-540-89760-6

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