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Hormonale Kontrazeption

  • Chapter
Klinische Endokrinologie für Frauenärzte

Zusammenfassung

Die erste „Pille“ wurde 1960 in den USA (Enovid: 150 µg Mestranol und 9,85 mg Norethynodrel) und 1961 in Deutschland (Anovlar: 50 µg Ethinylestradiol und 4 mg Norethisteron) zugelassen. Nachdem schon bald erste Berichte über Thromboembolien und arterielle Erkrankungen veröffentlicht wurden, bestand das weitere Bestreben darin, neue Präparate mit geringeren Risiken zu entwickeln. Durch die deutliche Reduktion der Ethinylestradioldosis bis auf 20 µg/ Tag ließ sich das Thromboserisiko signifikant reduzieren. Ferner entwickelte man neue Gestagene, die nur geringe oder keine androgenen Partialwirkungen aufwiesen (Desogestrel, Norgestimat, Gestoden, Dienogest). Einige von ihnen können aufgrund ihrer starken Wirksamkeit niedriger dosiert werden. Allerdings ist es fraglich, ob dies auch mit einem geringeren Risiko für kardiovaskuläre Ereignisse verbunden ist.

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Authors and Affiliations

  1. Klinik für Gynäkologie und Geburtshilfe, Klinikum der Johann-Wolfgang-Goethe-Universität Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt

    Inka Wiegratz Priv.-Doz. Dr. med.

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  1. Inka Wiegratz Priv.-Doz. Dr. med.
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  1. Lokstedter Damm 15, 22453, Hamburg

    Freimut Leidenberger

  2. Abt. für Gynäkologische Endokrinologie und Fertilitätsstörungen, Universitätsklinikum Heidelberg, Voßstraße 9, 69115, Heidelberg

    Thomas Strowitzki

  3. Klinik für Frauenheilkunde und Geburtshilfe der Universität Regensburg am Caritas-Krankenhaus St. Josef, Landshuter Straße 65, 93053, Regensburg

    Olaf Ortmann

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Wiegratz, I. (2009). Hormonale Kontrazeption. In: Leidenberger, F., Strowitzki, T., Ortmann, O. (eds) Klinische Endokrinologie für Frauenärzte. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-89760-6_11

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  • DOI: https://doi.org/10.1007/978-3-540-89760-6_11

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