4.7 Conclusions
The histological spectrum of HS is broad. The disease appears to be predominantly follicular and apocrine glands appear to be primarily involved in only a minority of histological specimens. Although inflammation does not appear to originate within the apocrine glands, the exclusive finding of the disease within apocrine-gland-bearing skin indicates an apocrine effect. This diversity of pathological presentation may well explain the therapeutic challenge that this condition poses.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Velpeau A. Dictionnaire de Medicine, un Repertoire General des Sciences Medicales Sous La Rapport Theorique et Pratique. Aiselle, Bechet, 1839
Verneuil A. Etudes sur les tumours de la peau et quelques maladies des glandes sudoripares. Arch Gen Med 1854; 4:447–468
Schiefferdecker B. Die Hautdrusen des Menschen, und der Saugetierre, ihre Histologische und rassenanatomische Bedeutung Sowie die Muscularis Sexualis. Schweizerbart, Stuttgart, 1922
Brunsting HA. Hidradenitis suppurativa; abscess of apocrine sweat glands — a study of clinical and pathological features with a report of 22 cases and a review of the literature. Arch Dermatol Syphilol 1939; 39:108–120
Shelly WB, Cahn MM. The pathogenesis of hidradenitis suppurativa in man. Arch Dermatol 1955; 72: 562–565
Yu CCW, Cook MG. Hidradenitis suppurativa: a disease of follicular epithelium, rather than apocrine glands. Br J Dermatol 1990; 122:763–769
Attanoos RL, Appleton MAC, Douglas-Jones AG. The pathogenesis of hidradenitis suppurativa: a closer look at apocrine and apoeccrine glands. Br J Dermatol 1995; 133:254–258
Boer J, Weltevreden EF. Hidradenitis suppurativa or acne inversa: a clinicopathological study of early lesions. Br J Dermatol 1996; 135:721–725
Brunsting HA. Hidradenitis and other variants of acne. Arch Dermatol Syphilol 1952; 65:303–315
Mortimer PS. Hidradenitis suppuritiva — diagnostic criteria. In: Marks R, Plewig G (eds) Acne and Related Disorders. Martin Dunitz, London, 1989, pp 359–360
Jemec GBE, Hansen U. Histology of hidradenitis suppurativa. J Am Acad Dermatol 1996; 34:994–999
Mortimer PS, Lunniss PJ. Hidradenitis suppurativa. J R Soc Med 2000; 93:420–422
Weedon D. Skin Pathology. Churchill Livingstone, Edinburgh, 1999, p 390
Fitzpatrick JE. Inflammatory reactions of the sweat unit. In: Farmer ER, Hood EF (eds) Pathology of the Skin. Appleton and Lange, Norwalk, 1990, pp 461–462
Heller DS, Haefner HK, Hameed M. J Reprod Med 2002; 47(9):695–689
Norris JFB, Cunliffe WJ. A histological and immunohistochemical study of early acne lesions. Br J Dermatol 1988; 118:651–659
Layton AM, Morris C, Cunliffe WJ, Ingham E. Immmunohistochemical investigation inflammation in lesions of acne. Clin Exp Dermatol 1998; 7:191–197
Kurokawa I, Nishijima S, Kusumoto K. Immunohistochemical study of cytokeratins in hidradenitis suppurativa (acne inversa). J Int Med Res 2002; 30:131–136
Pillsbury DM, Shelley WB, Kligman AM. Dermatology. Saunders, Philadelphia, 1956, p 481
Plewig G, Steger M. Acne inversa (alias acne triad, acne tetrad or hidradenitis suppurativa). In: Marks R, Plewig G (eds) Acne and Related Disorders. Martin Dunitz, London, 1988, pp 345–357
Kurokawa I, Nishijima S, Suzuki K. Cytokeratin expression in pilonidal sinus. Br J Dermatol 2002; 146:409–413
Attanoos RI, Appleton MA, Hughes LE. Granulomatous HS and cutaneous Crohn’s disease. Histopathology 1993; 23:111–115
Church JM, Fazio VW, Lavery IC. The differential diagnosis and comorbidity of HS and perianal Crohn’s disease-a further support to this association. Int J Colorectal Dis 1993; 8:117–119
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2006 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Layton, A. (2006). Pathology of Hidradenitis Suppurativa. In: Jemec, G.B.E., Revuz, J., Leyden, J.J. (eds) Hidradenitis Suppurativa. Springer, Berlin, Heidelberg . https://doi.org/10.1007/978-3-540-33101-8_4
Download citation
DOI: https://doi.org/10.1007/978-3-540-33101-8_4
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-33100-1
Online ISBN: 978-3-540-33101-8
eBook Packages: MedicineMedicine (R0)