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Genetics of Hidradenitis Suppurativa

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Hidradenitis Suppurativa

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References

  1. Antonarakis SE, McKusick VA (2000) OMIM passes the 1000-disease-gene mark. Nature Genet 25:11

    Article  PubMed  CAS  Google Scholar 

  2. Barth JH, Layton AM and Cunliffe WJ (1996) Endocrine factors in pre-and postmenopausal women with hidradenitis suppurativa. Br J Dermatol 134:1057–9

    Article  PubMed  CAS  Google Scholar 

  3. Bennett RE, Wilke WS and Murphy DP (1983) Spondyloarthropathy and hidradenitis suppurativa. Ann Intern Med 98:112

    PubMed  CAS  Google Scholar 

  4. Bleck O, McGrath JA and South AP (2001) Searching for candidate genes in the new millennium. Exp Dermatol 26:279–83

    Article  CAS  Google Scholar 

  5. Bohm M, Luger TA (1998) The pilosebaceous unit is part of the skin immune system. Dermatology 196:75–9

    Article  PubMed  CAS  Google Scholar 

  6. Bolland S, Ravetch JV (2000) Spontaneous autoimmune disease in FcγRIIB-deficient mice results from strain-specific epistasis. Immunity 13:277–85

    Article  PubMed  CAS  Google Scholar 

  7. Bonifas JM, Morley BJ, Oakey RE, Kan YW and Epstein Jr EH (1987) Cloning of a cDNA for steroid sulfatase: frequent occurrence of gene deletions in patients with recessive X chromosome-linked ichthyosis. Proc Natl Acad Sci USA 84:9248–51

    Article  PubMed  CAS  Google Scholar 

  8. Botstein D, Risch N (2003) Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease. Nature Genet 33:228–37

    Article  PubMed  CAS  Google Scholar 

  9. Brenneman DE, Phillips TM, Hauser J, Hill JM, Spong CY and Gozes I (2003) Complex array of cytokines released by vasoactive intestinal peptide. Neuropeptides 37:2

    Article  CAS  Google Scholar 

  10. Brunsting HA (1952) Hidradenitis and other variants of acne (1952) AMA Arch Derm Syphilol 65(3):303–15

    PubMed  CAS  Google Scholar 

  11. Burrows NP, Jones RR (1992) Crohn’s disease in association with hidradenitis suppurativa. Br J Dermatol 126:523

    Article  PubMed  CAS  Google Scholar 

  12. Cohen J (1985) Arthritis occurring with hidradenitis suppurativa. J Rheumatol 12:1208–9

    PubMed  CAS  Google Scholar 

  13. Consortium MGS (2002) Initial sequencing and comparative analysis of the mouse genome. Nature 420:520–62

    Article  CAS  Google Scholar 

  14. Delgado M, Ganea D (2003) Vasoactive intestinal peptide prevents activated microglia-induced neurodegeneration under inflammatory conditions: potential therapeutic role in brain trauma. FASEB J 17:1922–4

    PubMed  CAS  Google Scholar 

  15. Delgado M, Abad C, Martinez C, Leceta J and Gomariz RP (2001) Vasoactive intestinal peptide prevents experimental arthritis by downregulating both autoimmune and inflammatory components of the disease. Nature Med 7:563–8

    Article  PubMed  CAS  Google Scholar 

  16. Donis-Keller H, Green P, Helms C et al (1987) A genetic linkage map of the human genome. Cell 51:319–37

    Article  PubMed  CAS  Google Scholar 

  17. Eady EA, Cove JH (2000) Is acne an infection of blocked pilosebaceous follicles? Implications for antimicrobial treatment. Am J Clin Dermatol 1:201–9

    Article  PubMed  CAS  Google Scholar 

  18. Fitzsimmons JS, Guilbert PR (1985) A family study of hidradenitis suppurativa. J Med Genet 22:367–73

    PubMed  CAS  Google Scholar 

  19. Fitzsimmons JS, Fitzsimmons EM and Guilbert PR (1984) Familial hidradenitis suppurativa: evidence in favour of single gene transmission. J Med Genet 21:281–5

    Article  PubMed  CAS  Google Scholar 

  20. Fitzsimmons JS, Guilbert PR and Fitzsimmons EM (1985) Evidence of genetic factors in hidradenitis suppurativa. Br J Dermatol 113:1–8

    Article  PubMed  CAS  Google Scholar 

  21. Goischke HK, Ochsendorf FR (2001) [Acne inversa in Crohn’s disease]. Z Gastroenterol 39:965–9

    Article  PubMed  CAS  Google Scholar 

  22. Gold SC, Delaney TJ (1974) Familial acne conglobata, hidradenitis suppurativa, pili torti and cataracts. Br J Dermatol 91(10):54–7

    Article  Google Scholar 

  23. Gomariz RP, Martinez C, Abad C, Leceta J and Delgado M (2001) Immunology of VIP: a review and therapeutical perspectives. Curr Pharm Des 7:89–111

    Article  PubMed  CAS  Google Scholar 

  24. Guy R, Kealey T (1998) The effects of inflammatory cytokines on the isolated human sebaceous infundibulum. J Invest Dermatol 110:410–15

    Article  PubMed  CAS  Google Scholar 

  25. Harrison BJ, Read GF and Hughes LE (1988) Endocrine basis for the clinical presentation of hidradenitis suppurativa. Br J Surg 75:972–5

    PubMed  CAS  Google Scholar 

  26. Hellmann DB (1992) Spondyloarthropathy with hidradenitis suppurativa. J Am Med Assoc 267:2363–5

    Article  CAS  Google Scholar 

  27. Hernanz A, Medina S, de Miguel E and Martin-Mola E (2003) Effect of calcitonin gene-related peptide, neuropeptide Y, substance P and vasoactive intestinal peptide on interleukin-1beta, interleukin-6 and tumor necrosis factor-alpha production by peripheral whole blood cells from rheumatoid arthritis and osteoarthritis patients. Regul Pept 115:19–24

    Article  PubMed  CAS  Google Scholar 

  28. Jemec GB, Gniadecka M (1997) Ultrasound examination of hair follicles in hidradenitis suppurativa. Arch Dermatol 133:967–70

    Article  PubMed  CAS  Google Scholar 

  29. Jeremy AHT, Holland DB, Roberts SG, Thomson KF and Cunliffe WJ (2003) Inflammatory events are involved in acne lesion initiation. J Invest Dermatol 121:20–7

    Article  PubMed  CAS  Google Scholar 

  30. Kakurai M, Fujita N, Murata S, Furukawa Y, Demitsu T and Nakagawa H (2001) Vasoactive intestinal peptide regulates its receptor expression and functions of human keratinocytes via type I vasoactive intestinal peptide receptors. J Invest Dermatol 116:743–9

    Article  PubMed  CAS  Google Scholar 

  31. Kang S, Cho S, Chung JH et al (2005) Inflammation and extracellular matrix degradation mediated by activated transcription factors nuclear factor-kappaB and activator protein-1 in inflammatory acnes lesions in vivo. Am J Pathol 166(6):1691–9

    PubMed  CAS  Google Scholar 

  32. Katsanos KH, Christodoulou DK and Tsianos EV (2002) Axillary hidradenitis suppurativa successfully treated with infliximab in a Crohn’s disease patient. Am J Gastroenterol 97:2155–6

    Article  PubMed  Google Scholar 

  33. Khan MA (2002) Update on spondyloarthropathies. Ann Intern Med 136:896–907

    PubMed  Google Scholar 

  34. Klinge CM (2001) Estrogen receptor interaction with estrogen response elements. Nuc Acid Res 29:2905–19

    Article  CAS  Google Scholar 

  35. Knaggs HE, Holland DB, Morris C, Wood EJ and Cunliffe WJ (1994) Quantification of cellular proliferation in acne using the monoclonal antibody Ki67. J Invest Dermatol 102:89–92

    Article  PubMed  CAS  Google Scholar 

  36. Knaysi GA, Cosman B, Crikelair GF (1968) Hidradenitis suppurativa. J Am Med Assoc 203(1):73–6

    Article  Google Scholar 

  37. Laval SH, Timms A, Edwards S, Bradbury L, Brophy S, Milicic A, Rubin L, Siminovitch KA, Weeks DE, Calin A, Wordsworth BP and Brown MA (2001) Whole-genome screening in ankylosing spondylitis: evidence of non-MHC genetic-susceptibility loci. Am J Hum Genet 68:918–26

    Article  PubMed  CAS  Google Scholar 

  38. Lee YA, Ruschendorf F, Windemuth C, Schmitt-Egenolf M, Stadelmann A, Nurnberg G, Stander M, Wienker TF, Reis A and Traupe H (2000) Genomewide scan in German families reveals evidence for a novel psoriasis-susceptibility locus on chromosome 19p13. Am J Hum Genet 67:1020–4

    Article  PubMed  CAS  Google Scholar 

  39. Maquat LE (2001) The power of point mutations. Nature Genet 27:5–6

    Article  PubMed  CAS  Google Scholar 

  40. Martinez F, Nos P, Benlloch S and Ponce J (2001) Hidradenitis suppurativa and Crohn’s disease: response to treatment with infliximab. Inflamm Bowel Dis 7:323–6

    Article  PubMed  CAS  Google Scholar 

  41. McGrath JA (2004) Translational benefits from research on rare genodermatoses. Aust J Dermatol 45:89–93

    Article  Google Scholar 

  42. Mengesha YM, Holcombe TC and Hansen RC (1999) Prepubertal hidradenitis suppurativa: two case reports and review of the literature. Pediatr Dermatol 16:292–6

    Article  PubMed  CAS  Google Scholar 

  43. Mullis K, Faloona F, Scharf S, Saiki R, Horn G and Erlich H (1986) Specific enzymatic amplification of DNA in vitro: the polymerase chain reaction. Cold Spring Harb Symp Quant Biol 11:263–73

    Google Scholar 

  44. Oh HS, Smart RC (1996) An estrogen receptor pathway regulates the telogen-anagen hair follicle transition and influences epidermal cell proliferation. Proc Natl Acad Sci USA 93:12525–30

    Article  PubMed  CAS  Google Scholar 

  45. Ott VL, Tamir I, Niki M, Pandolfi PP and Cambier JC (2002) Downstream of kinase, p62(dok), is a mediator of Fc gamma IIB inhibition of Fc epsilon RI signalling. J Immunol 168:4430–9

    PubMed  CAS  Google Scholar 

  46. Pagani F, Buratti E, Stuani C, Bendix R, Dörk T and Baralle FE (2002) A new type of mutation causes a splicing defect in ATM. Nature Genet 30:426–9

    Article  PubMed  CAS  Google Scholar 

  47. Rioux JD, Silverberg MS, Daly MJ, Steinhart AH, McLeod RS, Griffiths AM, Green T, Brettin TS, Stone V, Bull SB, Bitton A, Williams CN, Greenberg GR, Cohen Z, Lander ES, Hudson TJ and Siminovitch KA (2000) Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci. Am J Hum Genet 66:1863–70

    Article  PubMed  CAS  Google Scholar 

  48. Rosner IA, Richter DE, Huettner TL, Kuffner GH, Wisnieski JJ and Burg CG (1982) Spondyloarthropathy associated with hidradenitis suppurativa and acne conglobata. Ann Intern Med 97:520–5

    PubMed  CAS  Google Scholar 

  49. Rosner IA, Burg CG, Wisnieski JJ, Schacter BZ and Richter DE (1993) The clinical spectrum of the arthropathy associated with hidradenitis suppurativa and acne conglobata. J Rheumatol 20:684–7

    PubMed  CAS  Google Scholar 

  50. Roy MK, Appleton MA, Delicata RJ, Sharma AK, Williams GT and Carey PD(1997) Probable association between hidradenitis suppurativa and Crohn’s disease: significance of epithelioid granuloma. Br J Surg 84:375–6

    Article  PubMed  CAS  Google Scholar 

  51. Spurr NK, Young BD and Bryant SP (1998) ICRF handbook of genome analysis. Blackwell Science, Oxford

    Google Scholar 

  52. Strachan T, Reid AP (1999) Human molecular genetics 2, 2nd edn. BIOS Scientific, Oxford

    Google Scholar 

  53. Takai T, Ono M, Hikida M, Ohmori H and Ravetch JV (1996) Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice. Nature 379:346–9

    Article  PubMed  CAS  Google Scholar 

  54. Terwilliger JD, Ott J (1994) Handbook of human genetic linkage, 1st edn. Johns Hopkins University Press, London

    Google Scholar 

  55. Thornton MJ (2002) Biological effects of estrogens on the skin. Exp Dermatol 11:487–502

    Article  PubMed  CAS  Google Scholar 

  56. Thornton MJ, Taylor AH, Mulligan K, Al-Azzawi F, Lyon CC, O’Driscoll J and Messenger AG (2003) The distribution of estrogen receptor beta is distinct to that of estrogen receptor alpha and the androgen receptor in human skin and the pilosebaceous unit. J Investig Dermatol Symp Proc 8:100–3

    Article  PubMed  CAS  Google Scholar 

  57. Tsianos EV, Dalekos GN, Tzermias C, Merkouropoulos M and Hatzis J (1995) Hidradenitis suppurativa in Crohn’s disease. A further support to this association. J Clin Gastroenterol 20:151–3

    Article  PubMed  CAS  Google Scholar 

  58. Venter JC et al (2001) The sequence of the human genome. Science 291:1304–51

    Article  PubMed  CAS  Google Scholar 

  59. Victor FC, Gottlieb AB (2002) TNF-alpha and apoptosis: implications for the pathogenesis and treatment of psoriasis. J Drugs Dermatol 1:264–75

    PubMed  Google Scholar 

  60. von der Werth JM, Williams HC (2000) The natural history of hidradenitis suppurativa. J Eur Acad Dermatol Venereol 14:389–92

    Article  PubMed  Google Scholar 

  61. von der Werth JM, Williams HC, Raeburn JA (2000) The clinical genetics of hidradenitis suppurativa revisited. Br J Dermatol 142:947–953

    Article  Google Scholar 

  62. Walter P, Green S, Greene G, Krust A, Bornert JM, Jeltsch JM, Staub A, Jensen E, Scrace G and Waterfield M (1985) Cloning of the human estrogen receptor cDNA. Proc Natl Acad Sci USA 82:7889–93

    Article  PubMed  CAS  Google Scholar 

  63. Weber JL, May PE (1989) Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. Am J Hum Genet 44:338–96

    Google Scholar 

  64. Wood P (2003) Molecular genetic analysis of inherited epidermal disorders. Thesis submitted for the Degree of Doctor of Philosophy, Molecular and Cellular Pathology, University of Dundee

    Google Scholar 

  65. Worton RG, Thompson MW (1988) Genetics of Duchenne muscular dystrophy. Annu Rev Genet 22:601–29

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Dermatology, St Leonards-on-Sea, UK

    Jan von der Werth

  2. Human Genetics Unit Division of Pathology and Neuroscience, Ninewells Hospital and Medical School University of Dundee, Dundee, DD1 9SY, UK

    Pam Wood

  3. Department of Paediatric Dermatology, Our Lady’s Hospital for Sick Children Crumlin, Dublin 12, Ireland

    Alan D. Irvine

  4. Human Genetics Unit Division of Pathology and Neuroscience Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK

    W. H. Irwin McLean

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  1. Jan von der Werth
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  2. Pam Wood
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  3. Alan D. Irvine
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  4. W. H. Irwin McLean
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Editor information

Editors and Affiliations

  1. Roskilde Hospital, Department of Dermatology, University of Copenhagen, Køgevej 7-13, 4000, Roskilde, Denmark

    Gregor B. E. Jemec MD, DMedSc

  2. Service Dermatologie, CHU Henri Mondor, Avenue Marechal de Lattre de Tassigny 51, 94010, Créteil, CX, France

    Jean Revuz MD, DMedSc

  3. Department of Dermatology, University Hospital of Pennsylvania, Spruce Street 3400, 19104, Philadelphia, USA

    James J. Leyden MD

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© 2006 Springer-Verlag Berlin Heidelberg

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von der Werth, J., Wood, P., Irvine, A.D., McLean, W.H.I. (2006). Genetics of Hidradenitis Suppurativa. In: Jemec, G.B.E., Revuz, J., Leyden, J.J. (eds) Hidradenitis Suppurativa. Springer, Berlin, Heidelberg . https://doi.org/10.1007/978-3-540-33101-8_10

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  • DOI: https://doi.org/10.1007/978-3-540-33101-8_10

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