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Novel Endoscopic Antireflux Procedures: Do They Have a Role in Patients with Hiatus Hernia?

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Hiatal Hernia Surgery

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Abstract

Endoscopic anti-reflux therapy (EART) is a relatively novel concept in the management of gastro-esophageal reflux disease (GERD) that intends to address three key issues: First, the need to treat refractory GERD, that is, to eliminate symptoms that are not completely controlled by proton pump inhibitor (PPI) use; second to eliminate long-term PPI use in those patients who, although well-controlled pharmacologically, are concerned about drug-related adverse events; and third to minimize the need for laparoscopic anti-reflux surgery (LARS) and its peri-operative and long-term sequelae [1]. Over the past 15 years, these clinical issues have become increasingly prevalent and clinically significant, thereby expanding the potential applicability and clinical value of EART. It has also become clear that not all patients with GERD are suitable candidates for such an option and that a careful, objective evaluation is needed in order to phenotypically characterize the disease and tailor therapy, aiming at producing the best long-term efficacy and safety.

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Abbreviations

ARMS:

Anti-reflux mucosectomy

EART:

Endoscopic anti-reflux therapy

GEJ:

Gastro-esophageal junction

GERD:

Gastroesophageal reflux disease

GERD-HRQL:

GERD health related quality of life

LARS:

Laparoscopic antireflux surgery

LESP:

Lower esophageal sphincter pressure

PPI:

Proton pump inhibitors

TF:

Transoral fundoplication

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Authors and Affiliations

  1. Stanford Multidimensional Program for Innovation and Research in the Esophagus (S-MPIRE), Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA, 94305, USA

    George Triadafilopoulos M.D.

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  1. George Triadafilopoulos M.D.
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Correspondence to George Triadafilopoulos M.D. .

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Editors and Affiliations

  1. Faculty of Health Sciences and Medicine, University of Southern Queensland Faculty of Health Sciences and Medicine, Toowoomba, Queensland, Australia

    Muhammed Ashraf Memon

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Conflict of Interest: The author has equity position with Mederi Therapeutics, C2 Therapeutics and EndoStim.

Human and Animal Rights and Informed Consent: This article does not contain any studies with human or animal subjects performed by the author.

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Triadafilopoulos, G. (2018). Novel Endoscopic Antireflux Procedures: Do They Have a Role in Patients with Hiatus Hernia?. In: Memon, M. (eds) Hiatal Hernia Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-64003-7_7

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  • DOI: https://doi.org/10.1007/978-3-319-64003-7_7

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