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Parallels Between Skeletal Muscle and Bone Aging

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Non-Pharmacological Management of Osteoporosis

Abstract

Skeletal muscle and bone share a common embryonic origin, form an integrated system that supports physical function, and concurrently undergo remarkable deterioration with aging. Although predominantly studied in isolation, progressive loss of skeletal muscle and deterioration of bone appear coordinated temporally, related mechanistically, and partnered clinically in the context of functional limitations, falls, and fractures. Herein, we discuss age-related changes in skeletal muscle and bone, their implications, and their underlying cellular mechanisms, with particular focus on an emerging area of cellular senescence.

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Author information

Authors and Affiliations

  1. Department of Physical Medicine and Rehabilitation, Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA

    Nathan K. LeBrasseur PhD

  2. Department of Physiology and Biomedical Engineering, Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA

    Nathan K. LeBrasseur PhD

  3. Department of Orthopedic Surgery, Mayo Clinic College of Medicine and Science, 200 First Street SW, Rochester, MN, 55905, USA

    Jennifer J. Westendorf PhD

  4. Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, 200 First Street SW, Rochester, MN, 55905, USA

    Jennifer J. Westendorf PhD

Authors
  1. Nathan K. LeBrasseur PhD
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  2. Jennifer J. Westendorf PhD
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Corresponding authors

Correspondence to Nathan K. LeBrasseur PhD or Jennifer J. Westendorf PhD .

Editor information

Editors and Affiliations

  1. Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, Minnesota, USA

    Mehrsheed Sinaki

  2. Institute of Clinical Osteology and Clinic “DER FÜRSTENHOF”, German Osteology Foundation, Bad Pyrmont, Niedersachsen, Germany

    Michael Pfeifer

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LeBrasseur, N.K., Westendorf, J.J. (2017). Parallels Between Skeletal Muscle and Bone Aging. In: Sinaki, M., Pfeifer, M. (eds) Non-Pharmacological Management of Osteoporosis. Springer, Cham. https://doi.org/10.1007/978-3-319-54016-0_4

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  • DOI: https://doi.org/10.1007/978-3-319-54016-0_4

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-54014-6

  • Online ISBN: 978-3-319-54016-0

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