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Drug Addiction and Histone Code Alterations

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Neuroepigenomics in Aging and Disease

Part of the book series: Advances in Experimental Medicine and Biology ((PMISB,volume 978))

Abstract

Acute and prolonged exposure to drugs of abuse induces changes in gene expression, synaptic function, and neural plasticity in brain regions involved in reward. Numerous genes are involved in this process, and persistent changes in gene expression coincide with epigenetic histone modifications and DNA methylation. Histone modifications are attractive regulatory mechanisms, which can encode complex environmental signals in the genome of postmitotic cells, like neurons. Recently, it has been demonstrated that specific histone modifications are involved in addiction-related gene regulatory mechanisms, by a diverse set of histone-modifying enzymes and readers. These histone modifiers and readers may prove to be valuable pharmacological targets for effective treatments for drug addiction.

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Acknowledgments

This work was supported by grants from NARSAD and NIMH.

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Authors and Affiliations

  1. Department of Basic Medical Sciences, University of Arizona College of Medicine-Phoenix, Phoenix, AZ, 85004, USA

    Hee-Dae Kim Ph.D., Tanessa Call B.A., Samantha Magazu M.S. & Deveroux Ferguson Ph.D.

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  1. Hee-Dae Kim Ph.D.
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  2. Tanessa Call B.A.
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  3. Samantha Magazu M.S.
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  4. Deveroux Ferguson Ph.D.
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Correspondence to Deveroux Ferguson Ph.D. .

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  1. Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), CATALONIA, Spain

    Raul Delgado-Morales

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Kim, HD., Call, T., Magazu, S., Ferguson, D. (2017). Drug Addiction and Histone Code Alterations. In: Delgado-Morales, R. (eds) Neuroepigenomics in Aging and Disease. Advances in Experimental Medicine and Biology(), vol 978. Springer, Cham. https://doi.org/10.1007/978-3-319-53889-1_7

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