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DNA Methylation in Schizophrenia

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Neuroepigenomics in Aging and Disease

Part of the book series: Advances in Experimental Medicine and Biology ((PMISB,volume 978))

Abstract

Schizophrenia is a highly heritable psychiatric condition that displays a complex phenotype. A multitude of genetic susceptibility loci have now been identified, but these fail to explain the high heritability estimates of schizophrenia. In addition, epidemiologically relevant environmental risk factors for schizophrenia may lead to permanent changes in brain function. In conjunction with genetic liability, these environmental risk factors—likely through epigenetic mechanisms—may give rise to schizophrenia, a clinical syndrome characterized by florid psychotic symptoms and moderate to severe cognitive impairment. These pathophysiological features point to the involvement of epigenetic processes. Recently, a wave of studies examining aberrant DNA modifications in schizophrenia was published. This chapter aims to comprehensively review the current findings, from both candidate gene studies and genome-wide approaches, on DNA methylation changes in schizophrenia.

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Authors and Affiliations

  1. Department of Psychiatry & Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands

    Lotta-Katrin Pries M.Sc., Sinan Gülöksüz M.D., Ph.D & Gunter Kenis Ph.D

  2. Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA

    Sinan Gülöksüz M.D., Ph.D

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  1. Lotta-Katrin Pries M.Sc.
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  2. Sinan Gülöksüz M.D., Ph.D
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  3. Gunter Kenis Ph.D
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Correspondence to Gunter Kenis Ph.D .

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  1. Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), CATALONIA, Spain

    Raul Delgado-Morales

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Pries, LK., Gülöksüz, S., Kenis, G. (2017). DNA Methylation in Schizophrenia. In: Delgado-Morales, R. (eds) Neuroepigenomics in Aging and Disease. Advances in Experimental Medicine and Biology(), vol 978. Springer, Cham. https://doi.org/10.1007/978-3-319-53889-1_12

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