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DNA Methylation in Major Depressive Disorder

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Neuroepigenomics in Aging and Disease

Part of the book series: Advances in Experimental Medicine and Biology ((PMISB,volume 978))

Abstract

Epigenetic mechanisms regulate gene expression, influencing protein levels and ultimately shaping phenotypes during life. However, both stochastic epigenetic variations and environmental reprogramming of the epigenome might influence neurodevelopment and ageing, and this may contribute to the origins of mental ill-health. Studying the role of epigenetic mechanisms is challenging, as genotype-, tissue- and cell type-dependent epigenetic changes have to be taken into account, while the nature of mental disorders also poses significant challenges for linking them with biological profiles. In this chapter, we summarise the current evidence suggesting the role of DNA methylation as a key epigenetic mechanism in major depressive disorder.

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Authors and Affiliations

  1. Complex Disease Epigenetic Group, University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK

    Ehsan Pishva M.D., Ph.D.

  2. Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Maastricht University, Universiteitssingel 50, Maastricht, 6200 MD, The Netherlands

    Ehsan Pishva M.D., Ph.D., Bart P. F. Rutten M.D., Ph.D. & Daniel van den Hove Ph.D.

  3. Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Fuechsleinstrasse 15, Wurzburg, 97080, Germany

    Daniel van den Hove Ph.D.

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  1. Ehsan Pishva M.D., Ph.D.
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  2. Bart P. F. Rutten M.D., Ph.D.
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  3. Daniel van den Hove Ph.D.
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Correspondence to Ehsan Pishva M.D., Ph.D. .

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  1. Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), CATALONIA, Spain

    Raul Delgado-Morales

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Pishva, E., Rutten, B.P.F., van den Hove, D. (2017). DNA Methylation in Major Depressive Disorder. In: Delgado-Morales, R. (eds) Neuroepigenomics in Aging and Disease. Advances in Experimental Medicine and Biology(), vol 978. Springer, Cham. https://doi.org/10.1007/978-3-319-53889-1_10

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