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Psychodermato-Oncology and Stress

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Stress and Skin Disorders

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Abstract

Skin cancer is the most common type of cancer around the world affecting specially fair-skinned populations. There are three types of skin cancer: basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma, originating from three major types of cells in the epidermis. Stress can affect, reveal or even exacerbate a number of skin disorders. Stress suppresses immune function and increases susceptibility to infections and skin cancers. In the other hand, receiving the diagnosis of skin cancer can be a stressful event and patients may go through an array of emotional reactions including anxiety and depression. This chapter presents the correlation of skin cancers and stress in different manners.

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References

  1. Saladi RN, Persaud AN. The causes of skin cancer: a comprehensive review. Drugs Today (Barc). 2005;41(1):37–53.

    Article  CAS  Google Scholar 

  2. Naldi L, Altieri A, Imberti GL, Giordano L, Gallus S, et al. Cutaneous malignant melanoma in women. Phenotypic characteristics, Sun exposure, and hormonal factors: a case–control study from Italy. Ann Epidemiol. 2005;15:545–50.

    Article  PubMed  Google Scholar 

  3. Xie J, Qureshi AA, Li Y, Han J. ABO blood group and incidence of skin cancer. Chan A-W, ed. PLoS One. 2010;5(8):e11972. doi:10.1371/journal.pone.0011972.

  4. Samarasinghe V, Madan V. Nonmelanoma skin cancer. J Cutan Aesthet Surg. 2012;5(1):3–10. doi:10.4103/0974-2077.94323.

    Article  PubMed  PubMed Central  Google Scholar 

  5. National Cancer Institute: PDQ® Skin cancer treatment. Bethesda: National Cancer Institute. Date last modified 20 Nov 2015. Available at: http://www.cancer.gov/types/skin/patient/skin-treatment-pdq. Accessed 20 Nov 2015.

  6. Dhabhar FS. Psychological stress and immunoprotection versus immunopathology in the skin. Clin Dermatol. 2013;31(1):18–30. doi:10.1016/j.clindermatol.2011.11.003.

    Article  PubMed  Google Scholar 

  7. Reich A, Wójcik-Maciejewicz A, Slominski AT. Stress and the skin. G Ital Dermatol Venereol. 2010;145(2):213–9.

    CAS  PubMed  Google Scholar 

  8. França K, Chacon A, Ledon J, Savas J, Nouri K. Pyschodermatology: a trip through history. An Bras Dermatol. 2013;88(5):842–3. doi:10.1590/abd1806-4841.20132059.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Winterbottom A, Harcourt D. Patients’ experience of the diagnosis and treatment of skin cancer. J Adv Nurs. 2004;48(3):226–33.

    Article  PubMed  Google Scholar 

  10. Me Marely. Skin cancer. Available at: http://www.healthcentral.com/skin-cancer/c/640929/116000/depression/#sthash.rU8UVqwi.dpuf. Accessed 11 Nov 2015.

  11. National Research Council (US). Committee on recognition and alleviation of distress in laboratory animals. Recognition and alleviation of distress in laboratory animals. Washington (DC): National Academies Press (US); 2008. 2. Stress and Distress: Definitions. Available from: http://www.ncbi.nlm.nih.gov/books/NBK4027/.

  12. No author listed. Understanding chronic stress. Available at: http://www.apa.org/helpcenter/understanding-chronic-stress.aspx. Accessed 11 Nov 2015.

  13. Saul AN, Oberyszyn TM, Daugherty C, et al. Chronic stress and susceptibility to skin cancer. J Natl Cancer Inst. 2005;97(23):1760–7. doi:10.1093/jnci/dji401.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. D’Orazio J, Jarrett S, Amaro-Ortiz A, Scott T. UV radiation and the skin. Int J Mol Sci. 2013;14(6):12222–48. doi:10.3390/ijms140612222.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Berton TR, Pavone A, Fischer SM. Ultraviolet-B irradiation alters the cell cycle machinery in murine epidermis in vivo. J Invest Dermatol. 2001;117(5):1171–8.

    Article  CAS  PubMed  Google Scholar 

  16. Dhabhar FS, Saul AN, Daugherty C, Holmes TH, Bouley DM, Oberyszyn TM. Short-term stress enhances cellular immunity and increases early resistance to squamous cell carcinoma. Brain Behav Immun. 2010;24(1):127–37. doi:10.1016/j.bbi.2009.09.004.

    Article  CAS  PubMed  Google Scholar 

  17. Dhabhar FS, Saul AN, Holmes TH, et al. High-anxious individuals show increased chronic stress burden, decreased protective immunity, and increased cancer progression in a mouse model of squamous cell carcinoma. Rameshwar P, ed. PLoS One. 2012;7(4):e33069. doi:10.1371/journal.pone.0033069.

  18. Fagundes CP, Glaser R, Johnson SL, et al. Basal cell carcinoma: stressful life events and the tumor environment. Arch Gen Psychiatry. 2012;69(6):618–26. doi:10.1001/archgenpsychiatry.2011.1535.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Betteridge DJ. What is oxidative stress? Metabolism. 2000;49(2 Suppl 1):3–8.

    Article  CAS  PubMed  Google Scholar 

  20. Young I, Woodside J. Antioxidants in health and disease. J Clin Pathol. 2001;54(3):176–86. doi:10.1136/jcp.54.3.176.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Kruk J, Duchnik E. Oxidative stress and skin diseases: possible role of physical activity. Asian Pac J Cancer Prev. 2014;15(2):561–8.

    Article  PubMed  Google Scholar 

  22. Sander CS, Hamm F, Elsner P, Thiele JJ. Oxidative stress in malignant melanoma and non-melanoma skin cancer. Br J Dermatol. 2003;148(5):913–22.

    Article  CAS  PubMed  Google Scholar 

  23. Trouba KJ, Hamadeh HK, Amin RP, Germolec DR. Oxidative stress and its role in skin disease. Antioxid Redox Signal. 2002;4(4):665–73.

    Article  CAS  PubMed  Google Scholar 

  24. Godic A, Poljšak B, Adamic M, Dahmane R. The role of antioxidants in skin cancer prevention and treatment. Oxid Med Cell Longev. 2014;2014:860479. doi:10.1155/2014/860479.

    Article  PubMed  PubMed Central  Google Scholar 

  25. França K, Cohen JL, Grunebaum L. Cosmeceuticals for recurrence prevention after prior skin cancer: an overview. J Drugs Dermatol. 2013;12(5):516–8.

    PubMed  Google Scholar 

  26. Institute of Medicine (US). Committee on psychosocial services to cancer patients/families in a community setting: Adler NE, Page AEK, editors. Cancer care for the whole patient: meeting psychosocial health needs. Washington (DC): National Academies Press (US); 2008. 1, The psychosocial needs of cancer patients. Available from: http://www.ncbi.nlm.nih.gov/books/NBK4011/.

  27. França K, Nouri K. Psychodermato-oncology: skin cancers in the elderly. NovaSci Publ. 2015;1:187–93.

    Google Scholar 

  28. Kasparian NA. Psychological stress and melanoma: are we meeting our patients’ psychological needs? Clin Dermatol. 2013;31(1):41–6. doi:10.1016/j.clindermatol.2011.11.005.

    Article  PubMed  Google Scholar 

  29. Vurnek Zivković M, Buljan M, Blajić I, Situm M. Psychological status and illness perceptions in patients with melanoma. Coll Antropol. 2008;32 Suppl 2:75–8.

    PubMed  Google Scholar 

  30. Beesley VL, et al. Supportive care needs, anxiety, depression and quality of life amongst newly diagnosed patients with localised invasive cutaneous melanoma in Queensland, Australia. Psychooncology. 2015;24(7):763–70. doi:10.1002/pon.3718. Epub 2014 Oct 29.

    Article  PubMed  Google Scholar 

  31. Erim Y, Loquai C, Schultheis U, Lindner M, Beckmann M, Schadendorf C, Senf W. Anxiety, posttraumatic stress, and fear of cancer progression in patients with melanoma in cancer aftercare. Onkologie. 2013;36:540–4.

    Article  PubMed  Google Scholar 

  32. Körner A, Fritzsche K. Psychosomatic services for melanoma patients in tertiary care. Int J Dermatol. 2012;51(9):1060–7. doi:10.1111/j.1365-4632.2011.05228.x.

    Article  PubMed  Google Scholar 

  33. Molassiotis A, Brunton L, Hodgetts J, Green AC, Beesley VL, Mulatero C, Newton-Bishop JA, Lorigan P. Prevalence and correlates of unmet supportive care needs in patients with resected invasive cutaneous melanoma. Ann Oncol. 2014;25(10):2052–8. doi:10.1093/annonc/mdu366. Epub 2014 Jul 31.

    Article  CAS  PubMed  Google Scholar 

  34. Beutel ME, Fischbeck S, Binder H, Blettner M, Brähler E, Emrich K, Friedrich-Mai P, Imruck BH, Weyer V, Zeissig SR. Depression, anxiety and quality of life in long-term survivors of malignant melanoma: a register-based cohort study. PLoS One. 2015;10(1):e0116440.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Antoszewski B, Kasielska A, Fijałkowska M. Face skin neoplasms--reasons for delayed treatment. Pol Przegl Chir. 2011;83(7):361–6. doi:10.2478/v10035-011-0057-x.

    PubMed  Google Scholar 

  36. Alam M, Goldberg LH, Silapunt S, Gardner ES, Strom SS, Rademaker AW, Margolis DJ. Delayed treatment and continued growth of nonmelanoma skin cancer. J Am Acad Dermatol. 2011;64(5):839–48. doi:10.1016/j.jaad.2010.06.028. Epub 2010 Nov 5.

    Article  PubMed  Google Scholar 

  37. Bath-Hextall F, Jenkinson C, Kumar A, Leonardi-Bee J, Perkins W, Cox K, Glazebrook C. Longitudinal, mixed method study to look at the experiences and knowledge of non melanoma skin cancer from diagnosis to one year. BMC Dermatol. 2013;13:13. doi:10.1186/1471-5945-13-13.

    Article  PubMed  PubMed Central  Google Scholar 

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Author information

Authors and Affiliations

  1. Centro Studi per la Ricerca Multidisciplinare e Rigenerativa, Università Degli Studi “G. Marconi”, Rome, Italy

    Katlein França MD, PhD

  2. Department of Dermatology and Cutaneous Surgery, Department of Psychiatry and Behavioral Sciences, Institute for Bioethics and Health Policy, University of Miami Miller School of Medicine, Miami, FL, USA

    Katlein França MD, PhD

  3. Centro Studi per la Ricerca Multidisciplinare e Rigenerativa, Università degli Studi Guglielmo Marconi, Rome, Italy

    Torello Lotti MD

Authors
  1. Katlein França MD, PhD
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  2. Torello Lotti MD
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Corresponding author

Correspondence to Katlein França MD, PhD .

Editor information

Editors and Affiliations

  1. Centro Studi per la Ricerca Multidisciplinare e Rigenerativa Department of Dermatology, Università degli Studi Guglielmo Marconi, Rome, Italy

    Katlein França

  2. Department of Psychiatry, Central Michigan University College of Medicine, Saginaw, Michigan, USA

    Mohammad Jafferany

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França, K., Lotti, T. (2017). Psychodermato-Oncology and Stress. In: França, K., Jafferany, M. (eds) Stress and Skin Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-46352-0_10

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  • DOI: https://doi.org/10.1007/978-3-319-46352-0_10

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-46351-3

  • Online ISBN: 978-3-319-46352-0

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