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Introduction

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Biological Basis of Alcohol-Induced Cancer

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 815))

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Abstract

Alcohol use disorders are a serious health problem having not only a profound primary effect on individuals, their life expectancy, and general health but also significant secondary effects on families and friends and a tertiary effect on society through the increased cost of health care and losses in productivity. The consumption of alcoholic beverages has long been an integral part of celebrations throughout the world. Some have even suggested a historic and evolutionary connection between humans and alcohol metabolism linking survival of our species with the ability to consume rotting fruit and eliminate alcohol [1]. In the early history of mankind, when much of the water may have been toxic or potentially filled with pathogens, consumption of alcohol may have been safer than consumption of water. The use and abuse of alcohol, whether to celebrate, grieve, or just cope with life’s ups and downs, has led to a culture that condones and encourages its use and yet in recent years has become increasingly aware of the dangers of overindulgence.

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References

  1. Dudley R (2000) Evolutionary origins of human alcoholism in primate frugivory. Q Rev Biol 75(1):3–15

    Article  CAS  PubMed  Google Scholar 

  2. Whiteford HA et al (2013) Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010. Lancet 382(9904):1575–1586

    Article  PubMed  Google Scholar 

  3. Newsholme A (1903) The possible association of the consumption of alcohol with excessive mortality from cancer. Br Med J 2(2241):1529–1531

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  4. IARC (1988) Alcohol drinking. Biological data relevant to the evaluation of carcinogenic risk to humans. IARC Monogr Eval Carcinog Risks Hum 44:101–152

    Google Scholar 

  5. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, World Health Organization, International Agency for Research on Cancer (2010) Alcohol consumption and ethyl carbamate, vol ix, IARC monographs on the evaluation of carcinogenic risks to humans. 2010, Lyon, France. International Agency for Research on Cancer, Lyon, 1424p; Distributed by WHO Press

    Google Scholar 

  6. Baan R et al (2007) Carcinogenicity of alcoholic beverages. Lancet Oncol 8(4):292–293

    Article  PubMed  Google Scholar 

  7. Hashibe M et al (2009) Interaction between tobacco and alcohol use and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. Cancer Epidemiol Biomarkers Prev 18(2):541–550

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  8. Grewal P, Viswanathen VA (2012) Liver cancer and alcohol. Clin Liver Dis 16(4):839–850

    Article  PubMed  Google Scholar 

  9. Allen NE et al (2009) Moderate alcohol intake and cancer incidence in women. J Natl Cancer Inst 101(5):296–305

    Article  PubMed  Google Scholar 

  10. Brooks PJ, Zakhari S (2013) Moderate alcohol consumption and breast cancer in women: from epidemiology to mechanisms and interventions. Alcohol Clin Exp Res 37(1):23–30

    Article  PubMed  Google Scholar 

  11. Klatsky AL et al (2014) Moderate alcohol intake and cancer: the role of underreporting. Cancer Causes Control 25(6):693–699

    Article  PubMed  Google Scholar 

  12. Liu Y et al (2012) Intakes of alcohol and folate during adolescence and risk of proliferative benign breast disease. Pediatrics 129(5):e1192–e1198

    Article  PubMed Central  PubMed  Google Scholar 

  13. Rehm J, Patra J, Popova S (2007) Alcohol drinking cessation and its effect on esophageal and head and neck cancers: a pooled analysis. Int J Cancer 121(5):1132–1137

    Article  CAS  PubMed  Google Scholar 

  14. Marietta C et al (2009) Acetaldehyde stimulates FANCD2 monoubiquitination, H2AX phosphorylation, and BRCA1 phosphorylation in human cells in vitro: implications for alcohol-related carcinogenesis. Mutat Res 664(1–2):77–83

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  15. Yokoyama A, Omori T (2005) Genetic polymorphisms of alcohol and aldehyde dehydrogenases and risk for esophageal and head and neck cancers. Alcohol 35(3):175–185

    Article  CAS  PubMed  Google Scholar 

  16. Shukla SD et al (2008) Emerging role of epigenetics in the actions of alcohol. Alcohol Clin Exp Res 32(9):1525–1534

    Article  CAS  PubMed  Google Scholar 

  17. Wainfan E et al (1989) Rapid appearance of hypomethylated DNA in livers of rats fed cancer-promoting, methyl-deficient diets. Cancer Res 49(15):4094–4097

    CAS  PubMed  Google Scholar 

  18. Shen L et al (1998) Correlation between DNA methylation and pathological changes in human hepatocellular carcinoma. Hepatogastroenterology 45(23):1753–1759

    CAS  PubMed  Google Scholar 

  19. Davis CD, Uthus EO (2004) DNA methylation, cancer susceptibility, and nutrient interactions. Exp Biol Med (Maywood) 229(10):988–995

    CAS  Google Scholar 

  20. McClain CJ et al (1998) Tumor necrosis factor and alcoholic liver disease. Alcohol Clin Exp Res 22(5 Suppl):248S–252S

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Gary J. Murray Ph.D. .

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© 2015 Springer International Publishing Switzerland

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Murray, G.J. (2015). Introduction. In: Vasiliou, V., Zakhari, S., Seitz, H., Hoek, J. (eds) Biological Basis of Alcohol-Induced Cancer. Advances in Experimental Medicine and Biology, vol 815. Springer, Cham. https://doi.org/10.1007/978-3-319-09614-8_1

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