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COG complex

  • Chapter
The Golgi Apparatus

Abstract

The conserved oligomeric Golgi (COG) protein complex consists of eight subunits named Cog1 through Cog8 (Kingsley et al. 1986; Ram et al. 2002; Suvorova et al. 2001, 2002; Ungar et al. 2002, Whyte and Munro 2001). Based on yeast genetic studies, biochemical observations and electron micrographs of the complex (Ungar et al. 2002) the COG subunits have been grouped into two lobes consisting of Cog1 to Cog4 and Cog5 to Cog8, respectively (Fig. 1). The two lobes appear to be interconnected by thin rods and/or globules. Cog1p is likely a bridging subunit between the two COG lobes in yeast (Fotso et al. 2005). The bridge that joins lobe A and lobe B in the mammalian COG complex is similarly composed of Cog1 and Cog8 (Oka et al. 2005; Ungar et al. 2005).

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Author information

Authors and Affiliations

  1. Department of Physiology and Biophysics, College of Medicine University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA

    Vladimir Lupashin

  2. Department of Biology, University of York, York, YO105YW, UK

    Daniel Ungar

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  1. Vladimir Lupashin
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  2. Daniel Ungar
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Editors and Affiliations

  1. Department of Cell Biology and Oncology, Consorzio Mario Negri Sud Laboratory of Intracellular Traffic, S. Maria Imbaro (Chieti), Italy

    Alexander A. Mironov

  2. Department of Cell Biology and Ultrastructure Research Institute of Histology and Embryology Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria

    Margit Pavelka

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© 2008 Springer-Verlag/Wien

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Lupashin, V., Ungar, D. (2008). COG complex. In: Mironov, A.A., Pavelka, M. (eds) The Golgi Apparatus. Springer, Vienna. https://doi.org/10.1007/978-3-211-76310-0_9

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