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SNAREs

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The Golgi Apparatus

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Abstract

Eukaryotic cells contain multiple membrane-bound compartments between which proteins and lipid molecules are continually shuttled via membrane-bound vesicular carriers. Despite the constant flux of proteins and lipid through these compartments their functional and composition integrity is maintained. While the molecular machinery involved in vesicle recognition and fusion can often be transport-step/fusion-event specific, one group of proteins & #x2014; the SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) play a common and central role in this process. Transport-step-specific combinations of SNARE proteins, localized to the vesicle and the target organelle, form complexes that facilitate the final step leading to the fusion of vesicles with their cognate target organelles. In general, the role of SNAREs appears to be conserved irrespective of their location of function in the cell, and much of what has been established for SNAREs in a particular trafficking pathway or organelle, is broadly applicable to SNAREs that function in the Golgi. Here we review Golgi SNAREs and the role they play in membrane and protein trafficking in the Golgi apparatus with, a particular emphasis on their functions in yeast and human cells.

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Authors and Affiliations

  1. Department of Biology The Hong Kong University of Science and Technology, Clear Water Bay, Knowloon, Hong Kong, SAR of China

    David K. Banfield

  2. Department of Biology The Hong Kong University of Science and Technology, Clear Water Bay, Knowloon Hong Kong, SAR of China

    Wanjin Hong

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  1. Department of Cell Biology and Oncology, Consorzio Mario Negri Sud Laboratory of Intracellular Traffic, S. Maria Imbaro (Chieti), Italy

    Alexander A. Mironov

  2. Department of Cell Biology and Ultrastructure Research Institute of Histology and Embryology Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria

    Margit Pavelka

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© 2008 Springer-Verlag/Wien

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Banfield, D.K., Hong, W. (2008). SNAREs. In: Mironov, A.A., Pavelka, M. (eds) The Golgi Apparatus. Springer, Vienna. https://doi.org/10.1007/978-3-211-76310-0_4

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