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Aneurysmal Fibrous Histiocytoma

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Soft Tissue Tumors
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Abstract

Aneurysmal fibrous histiocytoma is a low-grade fibrohistiocytic tumor. It is considered an uncommon variant of benign fibrous histiocytoma.

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Notes

  1. 1.

    LAMTOR1 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 1) encodes a protein involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. PRKCD encodes a member of the protein kinase C family of serine- and threonine-specific protein kinases (involved in a range of cell functions).

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  • Antony (2017) Aneurysmal variant of fibrous histiocytoma—a rare entity known for recurrence. J Clin Diagn Res 11(6):ED08–ED09

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  • Doyle (2013) Metastasizing “benign” cutaneous fibrous histiocytoma: a clinicopathologic analysis of 16 cases. Am J Surg Pathol 37(4):484–495

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  • Jedrych (2018) Aneurysmal fibrous histiocytomas with recurrent rearrangement of the PRKCD gene and LAMTOR1-PRKCD fusions. J Cutan Pathol 45(12):966–968

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Correspondence to Simone Mocellin .

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Mocellin, S. (2021). Aneurysmal Fibrous Histiocytoma. In: Soft Tissue Tumors . Springer, Cham. https://doi.org/10.1007/978-3-030-58710-9_16

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  • DOI: https://doi.org/10.1007/978-3-030-58710-9_16

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-58709-3

  • Online ISBN: 978-3-030-58710-9

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