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Prehabilitation

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Enhanced Recovery After Surgery

Abstract

Surgery is a stressful event. While efforts have been made to improve the intraoperative and immediate postoperative outcome with many ERAS evidence-based elements, little attention has been paid to the preoperative optimization, in particular the patient’s health status. Poor physical fitness has been associated with poor perioperative outcome, even when efforts have been made to optimize pharmacological and clinical conditions. To this extent, the preoperative period can be a salient time to intervene. Prehabilitation is the term that describes a program of optimization of functional capacity through exercise, nutrition, and coping strategies. The intent of this program, which has to be started before surgery, is to minimize the effect of surgical stress and metabolic deconditioning and to accelerate the return to baseline levels of functional capacity. Prehabilitation involves a preliminary screening and assessment of the patient’s physical, nutritional, and psychological qualities, followed by a structured and personalized multidisciplinary program started at least 4–5 weeks before surgery and to be continued after surgery if further impairments (e.g., chemotherapy) occur. The elderly, frail, and compromised patients need particular attention and can benefit most. The prehabilitation program in preparation for surgery can be housed in the preoperative clinic and requires the collaboration of surgeons, anesthesiologists, internists, family doctors, nurses, physiotherapists, nutritionists, kinesiologists, and psychologists.

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References

  1. Ljungqvist O, Scott M, Fearon KC. Enhanced recovery after surgery: a review. JAMA Surg. 2017;152(3):292–8.

    Article  PubMed  Google Scholar 

  2. Carli F, Zavorsky GS. Optimizing functional exercise capacity in the elderly surgical population. Curr Opin Clin Nutr Metab Care. 2005;8(1):23–32.

    Article  PubMed  Google Scholar 

  3. Minnella EM, Bousquet-Dion G, Awasthi R, Scheede-Bergdahl C, Carli F. Multimodal prehabilitation improves functional capacity before and after colorectal surgery for cancer: a five-year research experience. Acta Oncol. 2017;56(2):295–300.

    Article  PubMed  Google Scholar 

  4. Shah R, Attwood K, Arya S, Hall DE, Johanning JM, Gabriel E, et al. Association of frailty with failure to rescue after low-risk and high-risk inpatient surgery. JAMA Surg. 2018;153(5):e180214.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Slinger P. Principles and practice of anesthesia for thoracic surgery. New York: Springer; 2011.

    Book  Google Scholar 

  6. Grocott MPW, Plumb JOM, Edwards M, Fecher-Jones I, Levett DZH. Re-designing the pathway to surgery: better care and added value. Perioper Med (Lond, Engl). 2017;6:9.

    Article  Google Scholar 

  7. Schmitz KH, Courneya KS, Matthews C, Demark-Wahnefried W, Galvao DA, Pinto BM, et al. American College of Sports Medicine roundtable on exercise guidelines for cancer survivors. Med Sci Sports Exerc. 2010;42(7):1409–26.

    Article  PubMed  Google Scholar 

  8. Courneya KS, Friedenreich CM. Physical activity and cancer: an introduction. Recent results in cancer research Fortschritte der Krebsforschung Progres dans les recherches sur le. Cancer. 2011;186:1–10.

    Google Scholar 

  9. Tew GA, Ayyash R, Durrand J, Danjoux GR. Clinical guideline and recommendations on pre-operative exercise training in patients awaiting major non-cardiac surgery. Anaesthesia. 2018;73(6):750–68.

    Article  CAS  PubMed  Google Scholar 

  10. Arends J, Bachmann P, Baracos V, Barthelemy N, Bertz H, Bozzetti F, et al. ESPEN guidelines on nutrition in cancer patients. Clin Nutr (Edinb, Scotl). 2017;36(1):11–48.

    Article  Google Scholar 

  11. Weimann A, Braga M, Carli F, Higashiguchi T, Hubner M, Klek S, et al. ESPEN guideline: clinical nutrition in surgery. Clin Nutr (Edinb, Scotl). 2017;36(3):623–50.

    Article  Google Scholar 

  12. West MA, Lythgoe D, Barben CP, Noble L, Kemp GJ, Jack S, et al. Cardiopulmonary exercise variables are associated with postoperative morbidity after major colonic surgery: a prospective blinded observational study. Br J Anaesth. 2014;112(4):665–71.

    Article  CAS  PubMed  Google Scholar 

  13. Minnella EM, Carli F. Prehabilitation and functional recovery for colorectal cancer patients. Eur J Surg Oncol. 2018;44(7):919–26.

    Article  PubMed  Google Scholar 

  14. Brunelli A, Kim AW, Berger KI, Addrizzo-Harris DJ. Physiologic evaluation of the patient with lung cancer being considered for resectional surgery: diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2013;143(5 Suppl):e166S–e90S.

    Article  CAS  PubMed  Google Scholar 

  15. Minnella EM, Awasthi R, Gillis C, Fiore JF Jr, Liberman AS, Charlebois P, et al. Patients with poor baseline walking capacity are most likely to improve their functional status with multimodal prehabilitation. Surgery. 2016;160(4):1070–9.

    Article  PubMed  Google Scholar 

  16. Struthers R, Erasmus P, Holmes K, Warman P, Collingwood A, Sneyd JR. Assessing fitness for surgery: a comparison of questionnaire, incremental shuttle walk, and cardiopulmonary exercise testing in general surgical patients. Br J Anaesth. 2008;101(6):774–80.

    Article  CAS  PubMed  Google Scholar 

  17. Singer S, Kuhnt S, Gotze H, Hauss J, Hinz A, Liebmann A, et al. Hospital anxiety and depression scale cutoff scores for cancer patients in acute care. Br J Cancer. 2009;100(6):908–12.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Bruun LI, Bosaeus I, Bergstad I, Nygaard K. Prevalence of malnutrition in surgical patients: evaluation of nutritional support and documentation. Clin Nutr (Edinb, Scotl). 1999;18(3):141–7.

    Article  CAS  Google Scholar 

  19. White JV, Guenter P, Jensen G, Malone A, Schofield M. Consensus statement: academy of nutrition and dietetics and American Society for parenteral and enteral nutrition: characteristics recommended for the identification and documentation of adult malnutrition (undernutrition). JPEN J Parenter Enteral Nutr. 2012;36(3):275–83.

    Article  PubMed  Google Scholar 

  20. Flood A, Chung A, Parker H, Kearns V, O’Sullivan TA. The use of hand grip strength as a predictor of nutrition status in hospital patients. Clin Nutr (Edinb, Scotl). 2014;33(1):106–14.

    Article  Google Scholar 

  21. Kondrup J, Rasmussen HH, Hamberg O, Stanga Z. Nutritional risk screening (NRS 2002): a new method based on an analysis of controlled clinical trials. Clin Nutr (Edinb, Scotl). 2003;22(3):321–36.

    Article  Google Scholar 

  22. Ottery FD. Definition of standardized nutritional assessment and interventional pathways in oncology. Nutrition (Burbank, Los Angeles County, Calif). 1996;12(1 Suppl):S15–9.

    Article  CAS  Google Scholar 

  23. Richardson K, Levett DZH, Jack S, Grocott MPW. Fit for surgery? Perspectives on preoperative exercise testing and training. Br J Anaesth. 2017;119(suppl_1):i34–43.

    Article  CAS  PubMed  Google Scholar 

  24. West MA, Asher R, Browning M, Minto G, Swart M, Richardson K, et al. Validation of preoperative cardiopulmonary exercise testing-derived variables to predict in-hospital morbidity after major colorectal surgery. Br J Surg. 2016;103(6):744–52.

    Article  CAS  PubMed  Google Scholar 

  25. ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories. ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med. 2002;166(1):111–7.

    Article  Google Scholar 

  26. Levett DZH, Jack S, Swart M, Carlisle J, Wilson J, Snowden C, et al. Perioperative cardiopulmonary exercise testing (CPET): consensus clinical guidelines on indications, organization, conduct, and physiological interpretation. Br J Anaesth. 2018;120(3):484–500.

    Article  CAS  PubMed  Google Scholar 

  27. Howell D, Hack TF, Oliver TK, Chulak T, Mayo S, Aubin M, et al. Survivorship services for adult cancer populations: a pan-Canadian guideline. Curr Oncol (Toronto, Ont). 2011;18(6):e265–81.

    CAS  Google Scholar 

  28. Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983;67(6):361–70.

    Article  CAS  PubMed  Google Scholar 

  29. Santa Mina D, Clarke H, Ritvo P, Leung YW, Matthew AG, Katz J, et al. Effect of total-body prehabilitation on postoperative outcomes: a systematic review and meta-analysis. Physiotherapy. 2014;100(3):196–207.

    Article  CAS  PubMed  Google Scholar 

  30. Carli F, Scheede-Bergdahl C. Prehabilitation to enhance perioperative care. Anesthesiol Clin. 2015;33(1):17–33.

    Article  PubMed  Google Scholar 

  31. Wysokinski A, Sobow T, Kloszewska I, Kostka T. Mechanisms of the anorexia of aging-a review. Age (Dordr). 2015;37(4):9821.

    Article  Google Scholar 

  32. Organization WH. WHO global recommendations on physical activity for health. Geneva: World Health Organization; 2010.

    Google Scholar 

  33. Mishra SI, Scherer RW, Snyder C, Geigle PM, Berlanstein DR, Topaloglu O. Exercise interventions on health-related quality of life for people with cancer during active treatment. Cochrane Database Syst Rev. 2012;8:Cd008465.

    Google Scholar 

  34. Jones LW, Eves ND, Haykowsky M, Freedland SJ, Mackey JR. Exercise intolerance in cancer and the role of exercise therapy to reverse dysfunction. Lancet Oncol. 2009;10(6):598–605.

    Article  PubMed  Google Scholar 

  35. Cormie P, Atkinson M, Bucci L, Cust A, Eakin E, Hayes S, et al. Clinical Oncology Society of Australia position statement on exercise in cancer care. Med J Aust. 2018;209:184.

    Article  PubMed  Google Scholar 

  36. Campbell A, Stevinson C, Crank H. The BASES expert statement on exercise and cancer survivorship. J Sports Sci. 2012;30(9):949–52.

    Article  PubMed  Google Scholar 

  37. ACSM. American College of Sports Medicine’s guidelines for exercise testing and prescription. Baltimore: Lippincott Williams & Wilkins; 2013.

    Google Scholar 

  38. Fletcher GF, Ades PA, Kligfield P, Arena R, Balady GJ, Bittner VA, et al. Exercise standards for testing and training: a scientific statement from the American Heart Association. Circulation. 2013;128(8):873–934.

    Article  PubMed  Google Scholar 

  39. Chodzko-Zajko WJ, Proctor DN, Fiatarone Singh MA, Minson CT, Nigg CR, Salem GJ, et al. American College of Sports Medicine position stand. Exercise and physical activity for older adults. Med Sci Sports Exerc. 2009;41(7):1510–30.

    Article  PubMed  Google Scholar 

  40. Christensen T, Kehlet H. Postoperative fatigue. World J Surg. 1993;17(2):220–5.

    Article  CAS  PubMed  Google Scholar 

  41. Nelson ME, Rejeski WJ, Blair SN, Duncan PW, Judge JO, King AC, et al. Physical activity and public health in older adults: recommendation from the American College of Sports Medicine and the American Heart Association. Med Sci Sports Exerc. 2007;39(8):1435–45.

    Article  PubMed  Google Scholar 

  42. WHO. WHO global recommendations on physical activity for health. Geneva: World Health Organization; 2010.

    Google Scholar 

  43. Fearon KC, Jenkins JT, Carli F, Lassen K. Patient optimization for gastrointestinal cancer surgery. Br J Surg. 2013;100(1):15–27.

    Article  CAS  PubMed  Google Scholar 

  44. Nicolini A, Ferrari P, Masoni MC, Fini M, Pagani S, Giampietro O, et al. Malnutrition, anorexia and cachexia in cancer patients: a mini-review on pathogenesis and treatment. Biomed Pharmacother = Biomed Pharmacother. 2013;67(8):807–17.

    Article  CAS  PubMed  Google Scholar 

  45. Cynober LA. Metabolic & therapeutic aspects of amino acids in clinical nutrition. 2nd ed. Boca Raton: CRC Press; 2004.

    Google Scholar 

  46. Preston T, Slater C, McMillan DC, Falconer JS, Shenkin A, Fearon KC. Fibrinogen synthesis is elevated in fasting cancer patients with an acute phase response. J Nutr. 1998;128(8):1355–60.

    Article  CAS  PubMed  Google Scholar 

  47. Saunders J, Smith T, Stroud M. Malnutrition and undernutrition. Medicine. 2011;39(1):45–50.

    Article  Google Scholar 

  48. Laur CV, McNicholl T, Valaitis R, Keller HH. Malnutrition or frailty? Overlap and evidence gaps in the diagnosis and treatment of frailty and malnutrition. Appl Physiol Nutr Metab = Physiol Appl Nutr Metab. 2017;42(5):449–58.

    Article  Google Scholar 

  49. Dello SA, Lodewick TM, van Dam RM, Reisinger KW, van den Broek MA, von Meyenfeldt MF, et al. Sarcopenia negatively affects preoperative total functional liver volume in patients undergoing liver resection. HPB. 2013;15(3):165–9.

    Article  PubMed  PubMed Central  Google Scholar 

  50. Older P, Smith R, Courtney P, Hone R. Preoperative evaluation of cardiac failure and ischemia in elderly patients by cardiopulmonary exercise testing. Chest. 1993;104(3):701–4.

    Article  CAS  PubMed  Google Scholar 

  51. Gillis C, Carli F. Promoting perioperative metabolic and nutritional care. Anesthesiology. 2015;123(6):1455–72.

    Article  CAS  PubMed  Google Scholar 

  52. Tangvik RJ, Tell GS, Eisman JA, Guttormsen AB, Henriksen A, Nilsen RM, et al. The nutritional strategy: four questions predict morbidity, mortality and health care costs. Clin Nutr (Edinb, Scotl). 2014;33(4):634–41.

    Article  Google Scholar 

  53. Guerra RS, Sousa AS, Fonseca I, Pichel F, Restivo MT, Ferreira S, et al. Comparative analysis of undernutrition screening and diagnostic tools as predictors of hospitalisation costs. J Hum Nutr Diet. 2016;29(2):165–73.

    Article  CAS  PubMed  Google Scholar 

  54. Agarwal E, Ferguson M, Banks M, Batterham M, Bauer J, Capra S, et al. Malnutrition and poor food intake are associated with prolonged hospital stay, frequent readmissions, and greater in-hospital mortality: results from the nutrition care day survey 2010. Clin Nutr (Edinb, Scotl). 2013;32(5):737–45.

    Article  Google Scholar 

  55. Vaid S, Bell T, Grim R, Ahuja V. Predicting risk of death in general surgery patients on the basis of preoperative variables using American College of Surgeons National Surgical Quality Improvement Program data. Perm J. 2012. Fall;16(4):10–7.

    Article  PubMed  PubMed Central  Google Scholar 

  56. Sorensen J, Kondrup J, Prokopowicz J, Schiesser M, Krahenbuhl L, Meier R, et al. EuroOOPS: an international, multicentre study to implement nutritional risk screening and evaluate clinical outcome. Clin Nutr (Edinb, Scotl). 2008;27(3):340–9.

    Article  Google Scholar 

  57. Kwag SJ, Kim JG, Kang WK, Lee JK, Oh ST. The nutritional risk is a independent factor for postoperative morbidity in surgery for colorectal cancer. Ann Surg Treat Res. 2014;86(4):206–11.

    Article  PubMed  PubMed Central  Google Scholar 

  58. Schiesser M, Kirchhoff P, Muller MK, Schafer M, Clavien PA. The correlation of nutrition risk index, nutrition risk score, and bioimpedance analysis with postoperative complications in patients undergoing gastrointestinal surgery. Surgery. 2009;145(5):519–26.

    Article  PubMed  Google Scholar 

  59. Sun Z, Kong XJ, Jing X, Deng RJ, Tian ZB. Nutritional risk screening 2002 as a predictor of postoperative outcomes in patients undergoing abdominal surgery: a systematic review and meta-analysis of prospective cohort studies. PLoS One. 2015;10(7):e0132857.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  60. Jeejeebhoy KN, Keller H, Gramlich L, Allard JP, Laporte M, Duerksen DR, et al. Nutritional assessment: comparison of clinical assessment and objective variables for the prediction of length of hospital stay and readmission. Am J Clin Nutr. 2015;101(5):956–65.

    Article  CAS  PubMed  Google Scholar 

  61. Kassin MT, Owen RM, Perez SD, Leeds I, Cox JC, Schnier K, et al. Risk factors for 30-day hospital readmission among general surgery patients. J Am Coll Surg. 2012;215(3):322–30.

    Article  PubMed  PubMed Central  Google Scholar 

  62. Curtis LJ, Bernier P, Jeejeebhoy K, Allard J, Duerksen D, Gramlich L, et al. Costs of hospital malnutrition. Clin Nutr (Edinb, Scotl). 2017;36(5):1391–6.

    Article  Google Scholar 

  63. Malietzis G, Currie AC, Athanasiou T, Johns N, Anyamene N, Glynne-Jones R, et al. Influence of body composition profile on outcomes following colorectal cancer surgery. Br J Surg. 2016;103(5):572–80.

    Article  CAS  PubMed  Google Scholar 

  64. Martin L, Hopkins J, Malietzis G, Jenkins JT, Sawyer MB, Brisebois R, et al. Assessment of Computed Tomography (CT)-defined muscle and adipose tissue features in relation to short-term outcomes after elective surgery for colorectal cancer: a multicenter approach. Ann Surg Oncol. 2018;25(9):2669–80.

    Article  PubMed  Google Scholar 

  65. Ljungqvist O. ERAS–enhanced recovery after surgery: moving evidence-based perioperative care to practice. JPEN J Parenter Enteral Nutr. 2014;38(5):559–66.

    Article  PubMed  Google Scholar 

  66. Keller H, Allard J, Vesnaver E, Laporte M, Gramlich L, Bernier P, et al. Barriers to food intake in acute care hospitals: a report of the Canadian Malnutrition Task Force. J Hum Nutr Diet. 2015;28(6):546–57.

    Article  CAS  PubMed  Google Scholar 

  67. Gillis C, Nguyen TH, Liberman AS, Carli F. Nutrition adequacy in enhanced recovery after surgery: a single academic center experience. Nutr Clin Pract. 2015;30(3):414–9.

    Article  PubMed  Google Scholar 

  68. Yeung SE, Hilkewich L, Gillis C, Heine JA, Fenton TR. Protein intakes are associated with reduced length of stay: a comparison between Enhanced Recovery After Surgery (ERAS) and conventional care after elective colorectal surgery. Am J Clin Nutr. 2017;106(1):44–51.

    CAS  PubMed  Google Scholar 

  69. Chelsia Gillis MG, Gramlich L. Food is medicine: a qualitative analysis of patient barriers to food intake in an Enhanced Recovery After Surgery (ERAS) setting from the Canadian Nutrition Society: scientific abstracts from the 9th Annual Scientific Meeting/Société Canadienne de nutrition: résumés scientifiques de la 9e réunion scientifique annuelle. Appl Physiol Nutr Metab. 2018;43(4 (Suppl. 1)):S1–S42.

    Article  Google Scholar 

  70. Allard JP, Keller H, Jeejeebhoy KN, Laporte M, Duerksen DR, Gramlich L, et al. Decline in nutritional status is associated with prolonged length of stay in hospitalized patients admitted for 7 days or more: a prospective cohort study. Clin Nutr (Edinb, Scotl). 2016;35(1):144–52.

    Article  Google Scholar 

  71. Allard JP, Keller H, Teterina A, Jeejeebhoy KN, Laporte M, Duerksen DR, et al. Factors associated with nutritional decline in hospitalised medical and surgical patients admitted for 7 d or more: a prospective cohort study. Br J Nutr. 2015;114(10):1612–22.

    Article  CAS  PubMed  Google Scholar 

  72. Keller H, Allard JP, Laporte M, Davidson B, Payette H, Bernier P, et al. Predictors of dietitian consult on medical and surgical wards. Clin Nutr (Edinb, Scotl). 2015;34(6):1141–5.

    Article  Google Scholar 

  73. Keller H, Payette H, Laporte M, Bernier P, Allard J, Duerksen D, et al. Patient-reported dietetic care post hospital for free-living patients: a Canadian Malnutrition Task Force Study. J Hum Nutr Diet. 2018;31(1):33–40.

    Article  CAS  PubMed  Google Scholar 

  74. Phillips SM. Protein requirements and supplementation in strength sports. Nutrition (Burbank, Los Angeles County, Calif). 2004;20(7–8):689–95.

    Article  CAS  Google Scholar 

  75. Gillis C, Fenton TR, Sajobi TT, Minnella EM, Awasthi R, Loiselle SE, et al. Trimodal prehabilitation for colorectal surgery attenuates post-surgical losses in lean body mass: a pooled analysis of randomized controlled trials. Clin Nutr (Edinb, Scotl). 2019;38(3):1053–60.

    Article  Google Scholar 

  76. Tang JE, Phillips SM. Maximizing muscle protein anabolism: the role of protein quality. Curr Opin Clin Nutr Metab Care. 2009;12(1):66–71.

    Article  CAS  PubMed  Google Scholar 

  77. Phillips SM, Tipton KD, Aarsland A, Wolf SE, Wolfe RR. Mixed muscle protein synthesis and breakdown after resistance exercise in humans. Am J Phys. 1997;273(1 Pt 1):E99–107.

    CAS  Google Scholar 

  78. Biolo G, Tipton KD, Klein S, Wolfe RR. An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein. Am J Phys. 1997;273(1 Pt 1):E122–9.

    CAS  Google Scholar 

  79. Bandura A. Self-efficacy: toward a unifying theory of behavioral change. Psychol Rev. 1977;84(2):191–215.

    Article  CAS  PubMed  Google Scholar 

  80. Bandura A. Self-efficacy: the exercise of control. W. H. Freeman: New York; 1997.

    Google Scholar 

  81. Moritz SE, Feltz DL, Fahrbach KR, Mack DE. The relation of self-efficacy measures to sport performance: a meta-analytic review. Res Q Exerc Sport. 2000;71(3):280–94.

    Article  CAS  PubMed  Google Scholar 

  82. Carli F, Charlebois P, Stein B, Feldman L, Zavorsky G, Kim DJ, et al. Randomized clinical trial of prehabilitation in colorectal surgery. Br J Surg. 2010;97(8):1187–97.

    Article  CAS  PubMed  Google Scholar 

  83. Seligman ME, Csikszentmihalyi M. Positive psychology. An introduction. Am Psychol. 2000;55(1):5–14.

    Article  CAS  PubMed  Google Scholar 

  84. Seligman ME, Steen TA, Park N, Peterson C. Positive psychology progress: empirical validation of interventions. Am Psychol. 2005;60(5):410–21.

    Article  PubMed  Google Scholar 

  85. Oh SH, Kim DK, Lee SU, Jung SH, Lee SY. Association between exercise type and quality of life in a community-dwelling older people: a cross-sectional study. PLoS One. 2017;12(12):e0188335.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  86. Peterson C, Stunkard AJ. Personal control and health promotion. Soc Sci Med (1982). 1989;28(8):819–28.

    Article  CAS  Google Scholar 

  87. Williams SL, French DP. What are the most effective intervention techniques for changing physical activity self-efficacy and physical activity behaviour–and are they the same? Health Educ Res. 2011;26(2):308–22.

    Article  CAS  PubMed  Google Scholar 

  88. Barberan-Garcia A, Ubre M, Roca J, Lacy AM, Burgos F, Risco R, et al. Personalised Prehabilitation in high-risk patients undergoing elective major abdominal surgery: a randomized blinded controlled trial. Ann Surg. 2018;267(1):50–6.

    Article  PubMed  Google Scholar 

  89. Gillis C, Buhler K, Bresee L, Carli F, Gramlich L, Culos-Reed N, et al. Effects of nutritional prehabilitation, with and without exercise, on outcomes of patients who undergo colorectal surgery: a systematic review and meta-analysis. Gastroenterology. 2018;155(2):391–410.e4.

    Article  PubMed  Google Scholar 

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Minnella, E.M., Gillis, C., Edgar, L., Carli, F. (2020). Prehabilitation. In: Ljungqvist, O., Francis, N., Urman, R. (eds) Enhanced Recovery After Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-33443-7_10

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