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Head and Neck Cancer

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Intraoperative Irradiation

Part of the book series: Current Clinical Oncology ((CCO))

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Abstract

Intraoperative radiation therapy (IORT) represents an attractive modality for treating head and neck cancers, an anatomic site in which a multiplicity of issues arise regarding total treatment package time, retreatment, organ function preservation, dosimetry of complex anatomic sites near critical structures, and integration with external-beam irradiation (EBRT) either in the primary setting or in the previously irradiated patient. Pioneered in the 1960s primarily by the Japanese for the treatment of gastrointestinal tumors [1] IORT has been investigated in USA and Europe as a way of “boost” dose in conjunction with conventional EBRT to treat malignancies with a high propensity for local recurrence such as locally advanced or recurrent colorectal, retroperitoneal sarcomas, and advanced gynecologic cancers. In the head and neck region, the major experience has been in the treatment of locoregionally recurrent cancers after a previous EBRT.

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References

  1. Abe M, Takahashi M. Intraoperative radiotherapy: the Japanese experience. Int J Radiat Oncol Biol Phys. 1981;7(7):863–8.

    Article  PubMed  CAS  Google Scholar 

  2. Parkin DM et al. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55(2):74–108.

    Article  PubMed  Google Scholar 

  3. Forastiere AA et al. Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med. 2003;349(22):2091–8.

    Article  PubMed  CAS  Google Scholar 

  4. Pointreau Y et al. Randomized trial of induction chemotherapy with cisplatin and 5-fluorouracil with or without docetaxel for larynx preservation. J Natl Cancer Inst. 2009;101(7):498–506.

    Article  PubMed  CAS  Google Scholar 

  5. Posner MR et al. Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer. N Engl J Med. 2007;357(17):1705–15.

    Article  PubMed  CAS  Google Scholar 

  6. de Arruda FF et al. Intensity-modulated radiation therapy for the treatment of oropharyngeal carcinoma: the Memorial Sloan-Kettering Cancer Center experience. Int J Radiat Oncol Biol Phys. 2006;64(2):363–73.

    Article  PubMed  Google Scholar 

  7. Yao M et al. The role of post-radiation therapy FDG PET in prediction of necessity for post-radiation therapy neck dissection in locally advanced head-and-neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 2004;59(4):1001–10.

    Article  PubMed  Google Scholar 

  8. Eisbruch A et al. Dysphagia and aspiration after chemoradiotherapy for head-and-neck cancer: which anatomic structures are affected and can they be spared by IMRT? Int J Radiat Oncol Biol Phys. 2004;60(5):1425–39.

    Article  PubMed  Google Scholar 

  9. Ang KK et al. Randomized trial addressing risk features and time factors of surgery plus radiotherapy in advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2001;51(3):571–8.

    Article  PubMed  CAS  Google Scholar 

  10. Bernier J et al. Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med. 2004;350(19):1945–52.

    Article  PubMed  CAS  Google Scholar 

  11. Cooper JS et al. Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. N Engl J Med. 2004;350(19):1937–44.

    Article  PubMed  Google Scholar 

  12. Peters LJ et al. Evaluation of the dose for postoperative radiation therapy of head and neck cancer: first report of a prospective randomized trial. Int J Radiat Oncol Biol Phys. 1993;26(1):3–11.

    Article  PubMed  CAS  Google Scholar 

  13. Rosenthal DI et al. Importance of the treatment package time in surgery and postoperative radiation therapy for squamous carcinoma of the head and neck. Head Neck. 2002;24(2):115–26.

    Article  PubMed  Google Scholar 

  14. Mittal BB et al. Intraoperative radiation of canine carotid artery, internal jugular vein, and vagus nerve. Therapeutic applications in the management of advanced head and neck cancers. Arch Otolaryngol Head Neck Surg. 1990;116(12):1425–30.

    PubMed  CAS  Google Scholar 

  15. Garrett P et al. Intraoperative radiation therapy for advanced or recurrent head and neck cancer. Int J Radiat Oncol Biol Phys. 1987;13(5):785–8.

    Article  PubMed  CAS  Google Scholar 

  16. Garrett P et al. Intraoperative radiation therapy in head and neck cancer. Indiana Med. 1988;81(9):780–2.

    PubMed  CAS  Google Scholar 

  17. Freeman SB et al. Intraoperative radiotherapy of head and neck cancer. Arch Otolaryngol Head Neck Surg. 1990;116(2):165–8.

    PubMed  CAS  Google Scholar 

  18. Chen AM et al. Intraoperative radiation therapy for recurrent head-and-neck cancer: the UCSF experience. Int J Radiat Oncol Biol Phys. 2007;67(1):122–9.

    Article  PubMed  Google Scholar 

  19. Martinez-Monge R et al. IORT in the management of locally advanced or recurrent head and neck cancer. Front Radiat Ther Oncol. 1997;31:122–5.

    Article  PubMed  CAS  Google Scholar 

  20. Nag S et al. Pilot study of intraoperative high dose rate brachytherapy for head and neck cancer. Radiother Oncol. 1996;41(2):125–30.

    Article  PubMed  CAS  Google Scholar 

  21. Nag S et al. Intraoperative single fraction high-dose-rate brachytherapy for head and neck cancers. Brachytherapy. 2005;4(3):217–23.

    Article  PubMed  Google Scholar 

  22. Nag S et al. Intraoperative high dose rate brachytherapy can be used to salvage patients with previously irradiated head and neck recurrences. Rev Med Univ Navarra. 1999;43(2):56–61.

    PubMed  CAS  Google Scholar 

  23. Hu K, et al. High dose-rate intraoperative radiation therapy for the treatment of head and neck cancer. In: 5th international conference for the International Society of Intraoperative Radiation Therapy. Madrid; 2008.

    Google Scholar 

  24. Haller JR et al. Mortality and morbidity with intraoperative radiotherapy for head and neck cancer. Am J Otolaryngol. 1996;17(5):308–10.

    Article  PubMed  CAS  Google Scholar 

  25. Nag S et al. The American Brachytherapy Society recommendations for high-dose-rate brachytherapy for head-and-neck carcinoma. Int J Radiat Oncol Biol Phys. 2001;50(5):1190–8.

    Article  PubMed  CAS  Google Scholar 

  26. Coleman CW et al. Adjuvant electron-beam IORT in high-risk head and neck cancer patients. Front Radiat Ther Oncol. 1997;31:105–11.

    Article  PubMed  CAS  Google Scholar 

  27. Rate WR et al. Intraoperative radiation therapy for recurrent head and neck cancer. Cancer. 1991;67(11):2738–40.

    Article  PubMed  CAS  Google Scholar 

  28. Toita T et al. Intraoperative radiation therapy (IORT) for head and neck cancer. Int J Radiat Oncol Biol Phys. 1994;30(5):1219–24.

    PubMed  CAS  Google Scholar 

  29. Singh B et al. Factors associated with complications in microvascular reconstruction of head and neck defects. Plast Reconstr Surg. 1999;103(2):403–11.

    Article  PubMed  CAS  Google Scholar 

  30. Most MD et al. Feasibility of flap reconstruction in conjunction with intraoperative radiation therapy for advanced and recurrent head and neck cancer. Laryngoscope. 2008;118(1):69–74.

    Article  PubMed  Google Scholar 

  31. Marucci L et al. Intraoperative radiation therapy as an “early boost” in locally advanced head and neck cancer: preliminary results of a feasibility study. Head Neck. 2008;30(6):701–8.

    Article  PubMed  Google Scholar 

  32. Freeman SB et al. Management of advanced cervical metastasis using intraoperative radiotherapy. Laryngoscope. 1995;105(6):575–8.

    Article  PubMed  CAS  Google Scholar 

  33. Maves MD, Bruns MD, Keenan MJ. Carotid artery resection for head and neck cancer. Ann Otol Rhinol Laryngol. 1992;101(9):778–81.

    PubMed  CAS  Google Scholar 

  34. Atkinson DP, Jacobs LA, Weaver AW. Elective carotid resection for squamous cell carcinoma of the head and neck. Am J Surg. 1984;148(4):483–8.

    Article  PubMed  CAS  Google Scholar 

  35. Biller HF et al. Carotid artery resection and bypass for neck carcinoma. Laryngoscope. 1988;98(2):181–3.

    Article  PubMed  CAS  Google Scholar 

  36. Grecula JC et al. Intensification regimen 2 for advanced head and neck squamous cell carcinomas. Arch Otolaryngol Head Neck Surg. 1999;125(12):1313–8.

    PubMed  CAS  Google Scholar 

  37. Grecula JC et al. Long-term follow-up on an intensified treatment regimen for advanced resectable head and neck squamous cell carcinomas. Cancer Invest. 2001;19(2):127–36.

    Article  PubMed  CAS  Google Scholar 

  38. Ozer E et al. Long-term results of a multimodal intensification regimen for previously untreated advanced resectable squamous cell cancer of the oral cavity, oropharynx, or hypopharynx. Laryngoscope. 2006;116(4):607–12.

    Article  PubMed  Google Scholar 

  39. Schuller DE et al. Multimodal intensification regimens for advanced, resectable, previously untreated squamous cell cancer of the oral cavity, oropharynx, or hypopharynx: a 12-year experience. Arch Otolaryngol Head Neck Surg. 2007;133(4):320–6.

    Article  PubMed  Google Scholar 

  40. Nag S et al. Intraoperative high-dose-rate brachytherapy for paranasal sinus tumors. Int J Radiat Oncol Biol Phys. 2004;58(1):155–60.

    Article  PubMed  Google Scholar 

  41. Nag S et al. IORT using electron beam or HDR brachytherapy for previously unirradiated head and neck cancers. Front Radiat Ther Oncol. 1997;31:112–6.

    Article  PubMed  CAS  Google Scholar 

  42. Nag S, Hu KS. Intraoperative high-dose-rate brachytherapy. Surg Oncol Clin N Am. 2003;12(4):1079–97.

    Article  PubMed  Google Scholar 

  43. Schmitt R, Berbit N, Puel S, et al. The use of intraoperative radiation therapy (IORT) for the treatment of T3-4 carcinoma of the base of tongue. In: Abe M, Takahashi N, editors. Intraoperative radiation therapy. Tokyo: Pergamon; 1991.

    Google Scholar 

  44. Nag S et al. Intraoperative electron beam radiotherapy for previously irradiated advanced head and neck malignancies. Int J Radiat Oncol Biol Phys. 1998;42(5):1085–9.

    Article  PubMed  CAS  Google Scholar 

  45. Chen AM et al. Recurrent salivary gland carcinomas treated by surgery with or without intraoperative radiation therapy. Head Neck. 2008;30(1):2–9.

    Article  PubMed  Google Scholar 

  46. Spaeth J et al. Intra-operative radiotherapy – 5 years of experience in the palliative treatment of recurrent and advanced head and neck cancers. Oncology. 1997;54(3):208–13.

    Article  PubMed  CAS  Google Scholar 

  47. Freeman SB et al. Intraoperative radiotherapy of skull base cancer. Laryngoscope. 1991;101(5):507–9.

    Article  PubMed  CAS  Google Scholar 

  48. Pinheiro AD et al. Intraoperative radiotherapy for head and neck and skull base cancer. Head Neck. 2003;25(3):217–25. discussion 225–6.

    Article  PubMed  Google Scholar 

  49. Vartanian JG et al. Pectoralis major and other myofascial/myocutaneous flaps in head and neck cancer reconstruction: experience with 437 cases at a single institution. Head Neck. 2004;26(12):1018–23.

    Article  PubMed  Google Scholar 

  50. Ozer E et al. Intensification regimen for advanced-stage resectable hypopharyngeal carcinoma. Arch Otolaryngol Head Neck Surg. 2006;132(4):385–9.

    Article  PubMed  Google Scholar 

  51. Malone JP, Stephens JA, Grecula JC. Disease control, survival, and functional outcome after multimodal treatment for advanced-stage tongue base cancer. Head Neck. 2004;26(7):561–72.

    Article  PubMed  Google Scholar 

  52. Nilles-Schendera A et al. IORT in floor of the mouth cancer. Front Radiat Ther Oncol. 1997;31:102–4.

    Article  PubMed  CAS  Google Scholar 

  53. Wolf G et al. Intraoperative radiation therapy in advanced thyroid cancer. Eur J Surg Oncol. 1995;21(4):357–9.

    Article  PubMed  CAS  Google Scholar 

  54. Schleicher UM et al. Intraoperative radiotherapy for pre-irradiated head and neck cancer. Radiother Oncol. 2001;58(1):77–81.

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Depatment of Radiation Oncology, Continuum Cancer Centers of New York, Beth Israel Medical Center, St Luke’s and Roosevelt Hospitals, Albert Einstein College of Medicine, New York, NY, 10003, USA

    Kenneth S. Hu & Louis B. Harrison

  2. Department of Radiation Oncology, University of California San Francisco, 1600 Divisadero Street, San Francisco, CA, 94143-1708, USA

    Sue Yom

  3. Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, 94305-5739, USA

    Michael J. Kaplan

  4. Department of Radiation Oncology, Navarra University Clinic, Pamplona, Spain

    Rafael Martinez-Monge

Authors
  1. Kenneth S. Hu
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  2. Sue Yom
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  3. Michael J. Kaplan
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  4. Rafael Martinez-Monge
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  5. Louis B. Harrison
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Corresponding author

Correspondence to Kenneth S. Hu .

Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, Mayo Clinic, East Shea Blvd 13400, Scottsdale, 85259, Arizona, USA

    Leonard L. Gunderson

  2. Dept. Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA

    Christopher G. Willett

  3. Gregorio Marañón, Depto. Radiación de Oncología, Hospital General Universitario, C/ Dr. Esquerdo 46, Madrid, 28007, Spain

    Felipe A. Calvo

  4. Albert Einstein College of Medicine, Radiation Oncology, Beth Israel Medical Center, Union Square East 10, New York, 10003, New York, USA

    Louis B. Harrison

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Hu, K.S., Yom, S., Kaplan, M.J., Martinez-Monge, R., Harrison, L.B. (2011). Head and Neck Cancer. In: Gunderson, L., Willett, C., Calvo, F., Harrison, L. (eds) Intraoperative Irradiation. Current Clinical Oncology. Humana Press. https://doi.org/10.1007/978-1-61779-015-7_9

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  • DOI: https://doi.org/10.1007/978-1-61779-015-7_9

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-61779-014-0

  • Online ISBN: 978-1-61779-015-7

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