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Generation and Regulation of B Cell Autoreactivity Arising in the Periphery

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Mechanisms of Lymphocyte Activation and Immune Regulation VI

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 406))

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Abstract

Recent work on the role of environmental antigens in activating autoreactivity underscores a potentially confounding complication to current models of peripheral tolerance. Cross-reactive B cells that bind both autoantigen and foreign antigen are capable of mediating tissue damage, yet may be subject to positive selection as a consequence of interaction with antigen and T cell help. This discussion will review our work with cross-reactive antibodies and suggest a hypothesis to explain their generation and subsequent regulation.

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Authors and Affiliations

  1. Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, 10461, USA

    Philip Kuo, Daniel Michael, Boaz Tadmor & Betty Diamond

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  1. Philip Kuo
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  2. Daniel Michael
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  1. University of California, Irvine, Irvine, California, USA

    Sudhir Gupta

  2. University of Colorado Health Sciences Center, Denver, Colorado, USA

    J. John Cohen

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Kuo, P., Michael, D., Tadmor, B., Diamond, B. (1996). Generation and Regulation of B Cell Autoreactivity Arising in the Periphery. In: Gupta, S., Cohen, J.J. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation VI. Advances in Experimental Medicine and Biology, vol 406. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0274-0_18

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  • DOI: https://doi.org/10.1007/978-1-4899-0274-0_18

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