Summary
B lymphocytes are subject to selection within germinal centers following somatic hyper-mutation on immunoglobulin variable region genes based on their ability to bind antigen with high affinity. Non-selected cells die by apoptosis. Tumors with features of germinal center B cells include follicular center cell lymphoma and Burkitt’s lymphoma. We have used the latter extensively as a neoplastic model of germinal center cells and have compared directly the behaviour of cell lines dervied from biopsy material with that of the normal counterparts. Here we describe some of our findings in the two systems with regard to signals regulating survival and apoptosis.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Liu, Y-J., Joshua, D.E., Williams, G.T., Smith, C.A., Gordon, J. and MacLennan, I.C.M. Mechanisms of antigen-driven selection in germinal centres. Nature, 1989, 342: 929–933.
Gordon J. CD40 and its ligand: central players in B lymphocyte survival, growth, and differentiation. Blood Rev. 1995. 9: 53–56.
Gregory, C.D., Dive, C., Henderson, S., Smith, C.A., Williams, G.T., Gordon, J. and Rickinson, A.B. Activation of Epstein-Barr virus latent genes protects human B cells from death by apoptosis. Nature 1991, 349: 612–614.
Knox, K.A. and Gordon, J. Signal transduction pathways involved in the regulation of survival in normal and neoplastic B lymphocytes. 1995. In: Apoptosis and the Immune Response (ed. C.D. Gregory) pp 313–339. Wiley-Liss, New York.
Holder, M., Grafton, G., MacDonald, I., Finney M. and Gordon, J. Engagement of CD20 suppresses apoptosis in germinal center B cells. Eur. J. Immunol. 1995, 25: 3160–3164.
Holder, M.J., Abbot, S.D., Mlner, A.E., Gregory, C.D., Casamyor, M., Johnson, G.D., MacLennan, I.C.M. and Gordon, J. Interleukin-2 expands and maintains IgM-plasmablasts froma CD5-positive subset containe dwithin the gemrinal center cell-enriched fraction of human tonsil. Int. Immunol. 1993. 5: 1059–1066.
Zupo, S., Rugari, E., Dono, M., Taborelli, G., Malavesi, F. and Ferrarini, M. CD38 signaling by agonistic monoclonal antibody prevents apoptosis of human germinal center B cells. Eur. J. Immunol. 1994. 24: 1218–1222.
Levy, Y. and Brouet, J-C. Interleukin-10 prevents spontaneous death of germinal center B cells by induction of the Bc1–2 protein. J. Clin. Invest. 1994. 93: 424–450.
MacDonald, I., Wang, H., Grand, R., Armitage, R.J., Fanslow, W.C., Gregory, C.D. and Gordon, J. Transforming growth factor-ßl cooperates with anti-Ig for the induction of apoptosis in group I (biopsy-like) Burkitt lymphoma cell lines. Blood (in press).
Holder, M.J., Wang, H., Milner, A.E., Casamayor, M. et al. Suppression of apoptosis in normal and neoplastic human B lymphocytes by CD40 ligand is independent of Bc1–2 induction. Eur. J. Immunol. 1993, 23: 2368–2371.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Springer Science+Business Media New York
About this chapter
Cite this chapter
Gordon, J., Gregory, C.D., Grafton, G., Pound, J.D. (1996). Signals for Survival and Apoptosis in Normal and Neoplastic B Lymphocytes. In: Gupta, S., Cohen, J.J. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation VI. Advances in Experimental Medicine and Biology, vol 406. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0274-0_15
Download citation
DOI: https://doi.org/10.1007/978-1-4899-0274-0_15
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-0276-4
Online ISBN: 978-1-4899-0274-0
eBook Packages: Springer Book Archive