Abstract
Adenosine appears to be an extremely important contributor to asthma and allergic inflammation. Mast cells, cells thought to be central to immediate hypersensitivity reactions, release markedly more histamine and other granule-associated mediators when activated in the presence of micromolar concentrations of adenosine.1,2 The release of newly-generated mediators such as the leukotrienes and prostaglandins is potentiated modestly by adenosine as well. Hypoxic lung and stimulated mast cells3 release adenosine, providing a ready local source of this molecule during allergic pulmonary inflammation.
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Marquardt, D.L. (1998). Mast Cell Adenosine Receptor Characteristics and Signaling. In: Griesmacher, A., Müller, M.M., Chiba, P. (eds) Purine and Pyrimidine Metabolism in Man IX. Advances in Experimental Medicine and Biology, vol 431. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5381-6_15
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DOI: https://doi.org/10.1007/978-1-4615-5381-6_15
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