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Aberrant Lacrimal Gland Development in an Anophthalmic Mutant Strain of Rat

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Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 438))

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Abstract

Anophthalmia (congenital absence of eyeball) is a rare congenital defect seen in laboratory animals of different species1–6 as well as in humans.7 Several instances of hereditary anophthalmia have been reported,3–6 where both unilateral and bilateral anophthalmic phenotypes have been found. Anophthalmia is also known to result as a teratogenic effect of drugs.7,8 Such teratogenic anophthalmia reported for laboratory rats was found to be bilateral as well as unilateral.8 Our institution has recently isolated a strain of mutant anophthalmic rats that were derived from a parent colony of inbred CFY rats.6

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© 1998 Springer Science+Business Media New York

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De, P.K. (1998). Aberrant Lacrimal Gland Development in an Anophthalmic Mutant Strain of Rat. In: Sullivan, D.A., Dartt, D.A., Meneray, M.A. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2. Advances in Experimental Medicine and Biology, vol 438. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5359-5_9

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  • DOI: https://doi.org/10.1007/978-1-4615-5359-5_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7445-9

  • Online ISBN: 978-1-4615-5359-5

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