Abstract
The secretory function of the lacrimal gland is influenced by the release of classic and peptide neurotransmitters from sensory, sympathetic, and parasympathetic nerve terminals in the gland. These neuronal pathways constitute an integrated system that regulates the integrity of the front of the eye, particularly the optical qualities of the cornea. In everyday experience, this relationship is evidenced by the rapid tearing response to corneal stimulation. The release of neuromodulators resulting from activation of these pathways leads to receptor activation, mobilization of intracellular second messengers, exocytosis, and synthesis of secretory proteins. Consequently, the processes of cell signaling and synthesis of new secretory material must be regulated in coordination with secretion to maintain the normal exocrine function of the gland.
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Nguyen, D.H., Beuerman, R.W., Meneray, M.A., Maitchouk, D. (1998). Sensory Denervation Leads to Deregulated Protein Synthesis in the Lacrimal Gland. In: Sullivan, D.A., Dartt, D.A., Meneray, M.A. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2. Advances in Experimental Medicine and Biology, vol 438. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5359-5_5
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DOI: https://doi.org/10.1007/978-1-4615-5359-5_5
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