Skip to main content
SpringerLink
Log in

Localized Morphea in Children

  • Chapter
Rheumaderm

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 455))

Abstract

We are following 60 patients with morphea and/or linear scleroderma at the Hospital for Sick Children, Toronto. Lesions may vary in depth from epidermal changes resembling lichen sclerosis, to superficial and deep dermal changes. The subcutaneous tissue, bone and muscle may be involved. There is no good clinical marker of the disease. Because of the variation in the time to cure, it is difficult to evaluate treatment regimens. We are currently using methotrexate weekly either orally or subcutaneously and monthly pulsed steroids for three months.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. De Silva U, Parish LC: Historical approach to scleroderma. Clinics in Dermatol. 12: 201–205. 1994.

    Article  Google Scholar 

  2. Peterson LS, Nelson AM, Daniel WP: Subspecialty clinics: Rheumatology and dermatology. Classification of morphea (localized scleroderma). Mayo Clin Proc. 70: 1068–1076. 1995.

    Article  PubMed  CAS  Google Scholar 

  3. Jablonska S: Scleroderma and pseudoscleroderma. 2nd Ed. Warsaw Poland: Polish Medical Publishers, pgs 537–546. 1975.

    Google Scholar 

  4. Buechner SA, Winkelmann RK, Lautenschlager S, Gilli L, Rufli T: Localized scleroderma associated with Borrelia burgdorferi infection. J Am Acad Dermatol. 29: 190–196. 1993.

    Article  PubMed  CAS  Google Scholar 

  5. Birdi M, Shore A, Rush P, et al: Childhood linear slceroderma — A possible role of thermography for evaluation. J Rheumatol. 19: 968–973. 1992.

    PubMed  CAS  Google Scholar 

  6. Meis JF, Koopman R, van Bergen B, Pool G, Melchers W: No evidence for a relation between Borrelia burgdorferi infection and old lesions of localized scleroderma (morphea). Letter to Editor. Arch Dermatol. 129: 386–387. 1993.

    CAS  Google Scholar 

  7. Rosenberg AM, Uziel Y, Krafchik BR, et al: Antinuclear antibodies in children with localized scleroderma. J Rheumatol. 22: 2337–2343. 1995.

    PubMed  CAS  Google Scholar 

  8. Sato S, Ihn H, Soma Y, et al: Antihistone antibodies in patients with localized scleroderma. Arthritis Rheum. 36: 1137–1141. 1993.

    Article  PubMed  CAS  Google Scholar 

  9. Takehara K, Moroi Y, Nakabayashi Y, Ishibashi Y: Antinuclear antibodies in localized scleroderma. Arthritis Rheum. 26: 612–616. 1983.

    Article  PubMed  CAS  Google Scholar 

  10. Birdi N, Laxer RM, Thorner P, Fritzler MJ, Silverman ED: Localized scleroderma progressing to systemic disease. Case report and review of the literature. Arthritis Rheum. 36(3): 410–415. 1993.

    CAS  Google Scholar 

  11. Uziel Y, Krafchik BR, Feldman B, Silverman ED, Rubin LA, Laxer RM: Serum levels of soluble inter-leukin-2 receptor. A marker of disease activity in localized scleroderma. Arthritis Rheum. 37(6): 898–901. 1994.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Dermatology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada, M5G 1X8

    Dr. B. R. Krafchik

Authors
  1. Dr. B. R. Krafchik
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. St. Luke’s Hospital, University of Malta Medical School, Malta, USA

    Carmel Mallia

  2. Jefferson Medical College, Thomas Jefferson Universit, Philadelphia, Pennsylvania, USA

    Jouni Uitto

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer Science+Business Media New York

About this chapter

Cite this chapter

Krafchik, B.R. (1999). Localized Morphea in Children. In: Mallia, C., Uitto, J. (eds) Rheumaderm. Advances in Experimental Medicine and Biology, vol 455. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4857-7_7

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-4857-7_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7203-5

  • Online ISBN: 978-1-4615-4857-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation