Abstract
The extracellular matrix of connective tissue of the skin consists of a large number of distinct matrix macromolecules which play a critical role in providing physiologic properties to normal skin. Within the dermis, collagen and elastic fibers are the two major fibrillar components of connective tissue, and they exist in a fibrous interwoven mesh- work structure associated with other extracellular macromolecules of the dermis, such as proteoglycan/glycosaminoglycan complexes, and a number of non-collagenous glycoproteins, including fibronectin and fibrillins (Tables 1 and 2). Encased in the fibrillar mesh- work are cells that interact with the extracellular matrix components through cell-matrix receptors, such as integrins.
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Uitto, J., and Fazio, M. Biology and Pathophysiology of the Extracellular Matrix in Dermis. In: Pathophysiology of Dermatologic Diseases (Soter, N.A., and Baden, H.P., eds), 2nd Edition, McGraw-Hill, New York, pp.349–367, 1990.
Uitto, J., Fazio, M.J., and Olsen, D.R. Heritable Disorders of Connective Tissue. In: Genetic Disorders of the Skin (Alper, J.C., ed), Mosby-Year Book, Inc., St. Louis, MO, pp. 287–319, 1991.
Uitto, J., McGrath, J., and Bernstein, E. The Dermis. In: Cutaneous Medicine and Surgery: An Integrated Program in Dermatology (K.A. Arndt, P.E. LeBoit, J.K. Robinson, and B.U. Wintroub, eds), W.B. Saunders Company, Philadelphia, PA, vol. 1, pp. 857–881, 1996.
Rosenbloom, J. The Elastic Fiber in Health and Disease. Progress in Dermatology, vol. 30(4), pp. 1–15, 1996.
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© 1999 Springer Science+Business Media New York
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Uitto, J. (1999). Heritable Connective Tissue Disorders. In: Mallia, C., Uitto, J. (eds) Rheumaderm. Advances in Experimental Medicine and Biology, vol 455. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4857-7_3
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DOI: https://doi.org/10.1007/978-1-4615-4857-7_3
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