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Regulation of Adipose Tissue Lipolysis, Importance for the Metabolic Syndrome

  • Chapter
New Concepts in the Pathogenesis of NIDDM

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 334))

Abstract

Adipose tissue plays a key role in the regulation of the energy balance. Energy rich free fatty acids are continuously stored as triglycerides in fat cells through esterification and released from adipose tissue through hydrolysis (lipolysis) of triglycsrides in adipocytes. Triglycerides in fat cells and blood can be exchanged through lipoprotein lipase in fat cells, which breaks down triglyceride rich lipoproteins (mainly of the very low density type) into free fatty acids and glycerol. Free fatty acids can then be taken up by the fat cells and be esterified to triglycerides, then they are released again from the fat cells through lipolysis. Fatty acids leaving adipose tissue are bound to albumin and thereafter transported in blood to the liver, where they are used as substrate for esterification to triglycerides and incorporation into lipoproteins. Small changes in the turnover rate of free fatty acids in adipose tissue may in the long-term cause marked alterations of triglycerides in plasma and in adipose tissue leading to hypertriglyceridemia and/or obesity.

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Authors and Affiliations

  1. Karolinska Institute Department of Medicine, Huddinge Hospital, Huddinge, S-141 86, Sweden

    Peter Arner

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  1. Peter Arner
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Editors and Affiliations

  1. Karolinska Hospital, Stockholm, Sweden

    Claes Göran Östenson  & Suad Efendić  & 

  2. University of Toronto, Toronto, Ontario, Canada

    Mladen Vranic

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© 1993 Springer Science+Business Media New York

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Arner, P. (1993). Regulation of Adipose Tissue Lipolysis, Importance for the Metabolic Syndrome. In: Östenson, C.G., Efendić, S., Vranic, M. (eds) New Concepts in the Pathogenesis of NIDDM. Advances in Experimental Medicine and Biology, vol 334. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2910-1_19

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  • DOI: https://doi.org/10.1007/978-1-4615-2910-1_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6262-3

  • Online ISBN: 978-1-4615-2910-1

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