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Substrates and the Regulation of Hepatic Glycogen Metabolism

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New Concepts in the Pathogenesis of NIDDM

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 334))

Abstract

Hepatic glycogen has traditionally been considered as the storage form of glucose when an excess of carbohydrate is available, as after meals. In the post-absorptive period glucose is released from glycogen by the process of glycogenolysis with an increasing contribution from gluconeogenesis as glycogen stores are depleted (Duderman, 1975). The processes of glycogen formation and glycogenolysis are controlled by the activity of glycogen synthase and phosphorylase which, in turn, are subject to finely-tuned regulatory mechanisms (eg. Hers, 1976; van de Werve and Jeanrenaud, 1987; Nuttall et al., 1988).

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Authors and Affiliations

  1. Diabetes and Metabolism Research Unit, Ottawa Civic Hospital and the University of Ottawa, 1053 Carling Ave., Ottawa, Canada, K1Y 4E9

    Jerry Radziuk, Susan Pye & Zi Zhang

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  1. Jerry Radziuk
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  2. Susan Pye
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  1. Karolinska Hospital, Stockholm, Sweden

    Claes Göran Östenson  & Suad Efendić  & 

  2. University of Toronto, Toronto, Ontario, Canada

    Mladen Vranic

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Radziuk, J., Pye, S., Zhang, Z. (1993). Substrates and the Regulation of Hepatic Glycogen Metabolism. In: Östenson, C.G., Efendić, S., Vranic, M. (eds) New Concepts in the Pathogenesis of NIDDM. Advances in Experimental Medicine and Biology, vol 334. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2910-1_17

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