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On Insulin Action in Vivo: The Single Gateway Hypothesis

  • Chapter
New Concepts in the Pathogenesis of NIDDM

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 334))

Abstract

It has become increasingly clear that insulin resistance plays an important role in the pathogenesis of chronic diseases of Westernized societies. Compelling evidence exists not only that insulin resistance is a risk factor for diabetes mellitus (1,2) but this metabolic characteristic is also associated with hypertension and atherosclerosis (3,4). In addition, there is evidence from the Pima Indians (5) and from high-risk offspring of two NIDDM parents (6) that insulin resistance is an inherited trait. Given that there must be one or more specific underlying mechanistic defects which are responsible for insulin resistance, and given its potential importance in the pathogenesis of chronic disease, it is incumbent upon us to continue to try to identify the cellular or molecular defects which underlie this condition.

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Authors and Affiliations

  1. Department of Physiology and Biophysics, University of Southern California School of Medicine, 1333 San Pablo Street, Los Angeles, CA, 90033, USA

    Richard N. Bergman, David C. Bradley & Marilyn Ader

Authors
  1. Richard N. Bergman
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  2. David C. Bradley
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  3. Marilyn Ader
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Editors and Affiliations

  1. Karolinska Hospital, Stockholm, Sweden

    Claes Göran Östenson  & Suad Efendić  & 

  2. University of Toronto, Toronto, Ontario, Canada

    Mladen Vranic

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© 1993 Springer Science+Business Media New York

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Bergman, R.N., Bradley, D.C., Ader, M. (1993). On Insulin Action in Vivo: The Single Gateway Hypothesis. In: Östenson, C.G., Efendić, S., Vranic, M. (eds) New Concepts in the Pathogenesis of NIDDM. Advances in Experimental Medicine and Biology, vol 334. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2910-1_13

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  • DOI: https://doi.org/10.1007/978-1-4615-2910-1_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6262-3

  • Online ISBN: 978-1-4615-2910-1

  • eBook Packages: Springer Book Archive

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