Abstract
Polynesians have a predisposition to hyperuricaemia and gout. A number of risk factors have been identified including obesity, hyperglycaemia and hypertriglyceridaemia, however renal disease is not one of the associated risk factors. Studies in healthy Maori men1 established that the factor which put them at risk for hyperuricaemia and gout was an extremely reduced fractional clearance of uric acid, FEur (uric acid clearance factored by Creatinine clearance x 100%)1. Asymptomatic hyperuricaemia was identified in 23% of healthy Maori men, with a mean FEur (3.9%) lower than in the UK gouty male (5.4%). Even normouricaemic Maori males had a low FEur (4.9%) compared with UK males (8.1%).
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References
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© 1995 Springer Science+Business Media New York
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McBride, M.B., Simmonds, H.A., Hatfield, P.J., Jackson, M., McCaskey, J., Graham, R. (1995). Renal Urate Hypoexcretion in Polynesian Women is not as Severe as in United Kingdom (UK) Women with Familial Juvenile Hyperuricaemic Nephropathy (FJHN). In: Sahota, A., Taylor, M.W. (eds) Purine and Pyrimidine Metabolism in Man VIII. Advances in Experimental Medicine and Biology, vol 370. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2584-4_9
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DOI: https://doi.org/10.1007/978-1-4615-2584-4_9
Publisher Name: Springer, Boston, MA
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