Skip to main content

The Effect of Partial Hepatectomy on Blood Purine Levels in Rats and Patients

  • Chapter
Purine and Pyrimidine Metabolism in Man VIII

Abstract

Purine metabolism is a key metabolic process after partial hepatectomy in the synthesis of DNA and RNA, and in the energy metabolism for hepatic regeneration1. However it is not evaluated in clinical situations due to the difficulty in measuring changes of purine levels in the liver itself. In order to get a basic understanding of purine metabolism in clinical hepatectomy cases, blood samples are used for analysis in this study. Also, the liver is the main nondietary source of purines in mammalian cells2 and changes in blood level may affect purine metabolism in various tissues.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. M. Itakura, T. Maeda, M. Tsuchiya, and K. Yamashita, Increased rate of de novo purine synthesis and its mechanism in regenerating liver, Am J Physiol. 251:G585 (1986).

    PubMed  CAS  Google Scholar 

  2. A.W. Murry, The biological significance of purine salvage, Ann Rev Biochem 40: 811 (1971).

    Article  Google Scholar 

  3. V. Stocchi, L. Cucchiarine, F. Canestrari, M. Piacentini, and G. Fornani, A very fast ion-pair reversed-phase HPLC method for the separation of the most significant nucleotides and their degradation products in human red blood cells, Anal Biochem. 167:181 (1987).

    Article  PubMed  CAS  Google Scholar 

  4. T. Yamamoto, Y. Moriwaki, S. Takahashi, T. Hada, and K. Higashino, Separation of hypoxanthine and xanthine from pyrazinamide and its metabolites in plasma and urine by high-performance liquid chromatography, J. Chromatogr. 382:270 (1986).

    PubMed  CAS  Google Scholar 

  5. P. Kabasakalia, S. Kalliney, and A. Westcott, Enzymatic blood glucose determination by colorimetry of N, N-diethylailine-4-aminoantipyrine, Clin Chem. 20:606 (1974).

    Google Scholar 

  6. M. Usami, K. Furuchi, M. Ogino, J. Kotani, A. Iso, K. Oh, I. Yasuda, E. Sou, T. Kanamaru, H. Kasahara, Y. Saitoh, H. Yokoyama, and T. Yumisashi, Changes in purine and pyrimidine metabolism after partial hepatectomy in rats (in Japanese), Jap J Surg Metab Nutr. 27:35 (1993).

    CAS  Google Scholar 

  7. T. Kurokawa, T. Nonami, K. Kuroe, M. Satake, A. Harada, A. Nakano, and H. Takagi, Nucleotide metabolism in remnant rat liver after major hepatic resection (in Japanese), J Jap Surg Soc. 9:994 (1990).

    Google Scholar 

  8. S.H. Giler, O. Sperling, S. Brosh, I. Urca, and A. De Vries, Serum xanthine oxidase in jaundice, Clin Chim Acta. 63:37 (1975).

    Article  PubMed  CAS  Google Scholar 

  9. S. Ogoshi, M. Iwasa, T. Yonezawa, and T. Tamiya, Effect of nucleotide and nucleoside mixture on rats given total parenteral nutrition after 70% hepatectomy, J. Parenter Enterai Nutr. 9:339 (1985).

    Article  CAS  Google Scholar 

  10. H. Ohyanagi, S. Nishimatu, Y. Kanbara, M. Usami, and Y. Saitoh, Effect of nucleosides and a nucleotide on DNA and RNA syntheses by the salvage and de novo pathway in primary monolayer cultures of hepatocytes and hepatoma cells, J Parenter Enterai Nutr. 13:51 (1989).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer Science+Business Media New York

About this chapter

Cite this chapter

Usami, M. et al. (1995). The Effect of Partial Hepatectomy on Blood Purine Levels in Rats and Patients. In: Sahota, A., Taylor, M.W. (eds) Purine and Pyrimidine Metabolism in Man VIII. Advances in Experimental Medicine and Biology, vol 370. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2584-4_3

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-2584-4_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6105-3

  • Online ISBN: 978-1-4615-2584-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics