Abstract
The metabolism of uric acid and its levels in plasma and urine of gout patients have been extensively investigated1. Much less is known about the behavior of its precursors, hypoxanthine and xanthine in plasma and urine of the same patients. Reports in the literature are few and contradictory2, 3. Gutman et al.4 report no changes in plasma concentration and urinary excretion of oxypurines in gouty patients. McBurney and Gibson5 observed a non significant increase in plasma levels of hypoxanthine and xanthine in gout patients, with a high dispersion of values and greater variation of data within a group than between groups.
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References
J.B. Wyngaarden and W.N. Kelley. Epidemiology of hyper-uricaemia and gout, in: “Gout and hyperuricaemia”, J.B. Wyngaarden, W.N. Kelley, Academic Press, New York (1976).
A.B. Gutman, T.F. Yii and B. Weissman, The concept of secondary gout: relation to purine metabolism in polycytemia and myeloid metaplasia, Trans.Assoc.Am. Physician 69:229 (1956).
W.S. Adams, F. Davis and M. Nakatani, Purine and pyrimidine excretion in normal and leukemic subjects, Am. J.Med. 28:726(1960).
A.B. Gutman and F.F. Yu, A three component system for regulation of renal excretion of uric acid in man, Trans.Ass.Am.Phys. 74:353 (1961).
A. McBurney and T. Gibson, Reverse phase partition HPLC for determination of plasma purines and pyrimidines in subjects with gout and renal failure, Clin.Chim Acta 102:19 (1980).
H.A. Simmond, Urinary excretion of purines, pyrimidines and pyrazolopyrimidines in patients treated with allopurinol or oxypurinol, Clin.Chim.Acta; 23:353 (1969).
J.L. Chabard, C. Lartigne-Mattei, F. Verdone, J. Petit and J.A. Berger, Mass fragmentographic determination of xanthine and hypoxanthine in biological fluids, Chromatograph 221:9 (1980).
D. Vannoni, B. Porcelli, R. Leoncini, L. Terzuoli, M. Pizzichini, A. Di Stefano, E. Marinello and R. Marcolongo, The excretion of oxypurines in normal subjects, Biom. & Pharmacother. 43:513 (1989).
J.B. Wyngaarden and W.N. Kelley, Uric acid overproduction in gout, in: “Gout and hyperuricaemia”, J.B. Wyngaarden, W.N. Kelley, Academic Press, New York (1976).
R.A. Hartwick, A.M. Krstulovic and P.R. Brown, Identification and quantitation of nucleosides, bases and other UV-absorbing compounds in serum, using reversed phase high performance liquid chromatography, J. Chrom., 186:659(1979).
R. Bolieu, C. Bory, P. Baltassat and C. Gonnet, Simultaneous determination of allopurinol, oxypurinol, hypoxanthine and xanthine in biological fluids by high performance liquid chromatography, J. Chrom. 307:469 (1984).
A.B. Gutman and F.F. Yu F.F., Renal function in gout with a commentary on the renal regulation of urate excretion, and the role of the kidney in the pathogenesis of gout, Am. J. Med. 23:600 (1957).
M.L. Smith and J.T. Scott, Uric acid clearance in patients with gout and normal subjects, Ann.Rheum.Dis. 30:285 (1971).
J.G. Puig, F.A. Mateos, M.L. Jimenez, T. Ramos, M.C. Capitán and A.A. Gil, Impaired renal excretion of hypoxanthine and xanthine in primary gout, in: “Purine and pyrimidine metabolism in man VI”, New York, Plenum Press (1989).
A. Carcassi, R. Marcolongo and E. Marinello, Liver xanthine oxidase in gouty patients, Arthritis Rheum. 12:17(1969).
J. Bourgoignie, J.P. Pennel and A.J. Jacob, Sodium metabolism and volume regulation, in: “Current Nephrology”, Houghton Mifflin, Boston (1979).
M.G. Fitzgerald and P. Forman, An experimental study of magnesium deficiency in man, Clin.Sci. 15:635 (1965).
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Porcelli, B., Vannoni, D., Leoncini, R., Pizzichini, M., Pagani, R., Marinello, E. (1995). Free Oxypurines in Plasma and Urine of Gout Patients Before and After a Purine-Free Diet. In: Sahota, A., Taylor, M.W. (eds) Purine and Pyrimidine Metabolism in Man VIII. Advances in Experimental Medicine and Biology, vol 370. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2584-4_12
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DOI: https://doi.org/10.1007/978-1-4615-2584-4_12
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