Abstract
The principal function of the lacrimal gland is to provide an appropriate medium for the maintenance of the corneal epithelium. Insofar as the corneas of different species have unique requirements, we may expect that their lacrimal glands will have significant heterogeneity in form and function. The lacrimal contribution to tears is complex, and the protein secretory products of the lacrimal gland vary among different species. 1 Further, species specific heterogeneity is evident in the distinctly different organizations of the acini in rat and rabbit lacrimal glands.2 For instance, rat lacrimal acini are spherical or oval in structure whereas the rabbit acini are elongate, tubular and branching. Both species secrete numerous proteins, but the rat lacrimal gland contains at least 2 exocytotic proteins, peroxidase (PX) and carbonic anhydrase (CA), that are not secreted by the rabbit. Species specific differences probably also exist in the manner in which the aqueous portion of the lacrimal fluid is generated.3 The presence of a membrane-associated CA in the terminal acinar cells of rabbit but not rat lacrimal glands is consistent with this idea.2 This CA isozyme may have a unique role in the unidirectional transport of water,4 forming the aqueous component of the lacrimal fluid. The same task is likely achieved in a different manner in the non-terminal acinar cells of the rabbit lacrimal gland and in the rat lacrimal gland, which lacks altogether the acinar membrane-associated CA.2 Even within the glands of a single species there is significant heterogeneity among the acini, reflecting some partitioning of functions among the principal secretory cells.2,5
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Bromberg, B.B., Hanemann, C.W., Welch, M.H., Beuerman, R.W., Githens, S. (1994). Carbonic Anhydrase and Acinar Cell Heterogeneity in Rat and Rabbit Lacrimal Glands. In: Sullivan, D.A. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes. Advances in Experimental Medicine and Biology, vol 350. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2417-5_5
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DOI: https://doi.org/10.1007/978-1-4615-2417-5_5
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