Abstract
Translation is regulated predominantly at the initiation level, mediated by the eukaryotic initiation factor-4 and -2 complexes (eIF-4 and eIF-2).1, 2 The eIF-4 complex is essential for recruiting mRNA to a ribosome. The two most important components of this complex are the eIF-4E and eIF-4G. Phosphorylation of eIF-4E and eIF-4G increases protein synthesis as well as selective translation of specific messages.2
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© 2002 Kluwer Academic/Plenum Publishers
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Nguyen, D.H., Beuerman, R.W., Toshida, H. (2002). The Effects of Sensory and Parasympathetic Denervation on the Kinases and Initiation Factors Controlling Protein Synthesis in the Lacrimal Gland. In: Sullivan, D.A., Stern, M.E., Tsubota, K., Dartt, D.A., Sullivan, R.M., Bromberg, B.B. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. Advances in Experimental Medicine and Biology, vol 506. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0717-8_8
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DOI: https://doi.org/10.1007/978-1-4615-0717-8_8
Publisher Name: Springer, Boston, MA
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