Abstract
The sera of Sjögren’s syndrome patients frequently contain autoantibodies to proteins normally localized in intracellular compartments. These include the Ro/SSA and La/SSB ribonucleoproteins, which are expressed in the nuclei; fodrin, which mediates interactions between the cytoskeleton and plasma membrane, and as-yet-uncharacterized proteins that appear to be associated with the Golgi complex. Theories to explain the loss of tolerance to the classical Sjögren’s autoantigens generally begin with the premise that under normal circumstances they are exposed to the immune system at levels so low that tolerance can be maintained through peripheral mechanisms.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
A.M. Azzarolo, R.L. Wood, A.K. Mircheff, A. Richters, E. Olsen, M. Berkowitz, M. Bachmann, Z.M. Huang, R. Zolfagari, and D.W. Warren. Androgen influence on lacrimal gland apoptosis, necrosis, and lymphocytic infiltration. Invest Ophthalmol Vis Sci. 40:592 (1999).
S. Bacman, L. Sterin-Borda, J.J. Camusso, R. Arana, O. Hubscher, E. and Borda. Circulating antibodies against rat parotid gland M3 muscarinic receptors in primary Sjögren’s syndrome. Clin Exp Immunol. 104:454 (1996).
S. Bacman, C.P. Leiros, L. Sterin-Borda, O. Hubscher, R. Arana, and E. Borda. Autoantibodies against lacrimal gland M3 muscarinic acetylcholine receptors in patients with primary Sjögren’s syndrome. Invest Ophthalmol Vis Sci. 39:151 (1998).
J.P. Gierow, R.W. Lambert, and A.K. Mircheff. Fluid phase endocytosis by isolated rabbit lacrimal acinar cells. Exp. Eye Res. 60: 511 (1995).
J.P. Gierow, T. Yang, A. Bekmezian, N. Liu, J.M. Norian, S.A. Kim, S. Rafisolyman, H. Zeng, C.T. Okamoto, R.L. Wood, and A.K. Mircheff. Na,K-ATPase in lacrimal gland acinar cell endosomal system. Correcting a case of mistaken identity. Am J Physiol. 271:C1685 (1996).
Z. Guo, A.M. Azzarolo, J.E. Schechter, D.W. Warren, R.L. Wood, A.K. Mircheff, and H.R. Kaslow. Lacrimal gland epithelial cells stimulate proliferation in autologous lymphocyte preparations. Exp Eye Res. 71:11 (2000).
Z.M. Huang, J. Zhang, A.M. Azzarolo, A.K. Mircheff, R.L. Wood, and D.W. Warren. Expression and regulation of prolactin (PRL) messenger RNA in female rabbit lacrimal glands. Invest Ophthalmol Vis Sri. 38:S1155 (1997).
R.W. Lambert, C.A. Maves, and A.K. Mircheff. Carbachol-induced increase of Na+/H+ antiport and recruitment of Na+/K+-ATPase in rabbit lacrimal acini. Curr Eye Res. 12:539 (1993a).
R.W. Lambert, C.A. Maves, J.P. Gierow, R.L. Wood, and A.K. Mircheff. Plasma membrane internalization and recycling in rabbit lacrimal acinar cells. Invest Ophthalmol Vis Sci. 34:305 (1993b).
E.M. Rocha, L.A. Wickham, Z. Huang, I. Toda, J. Gao, L.A. da Silveira, and D.A. Sullivan Presence and testosterone influence on the levels of anti- and pro-inflammatory cytokines in lacrimal tissues of a mouse model of Sjögren’s syndrome. Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2, Sullivan, D.A., Dartt, D.A., and Meneray, M.A., eds., Plenum Press, New York (1998).
T. Yang, H. Zeng, J. Zhang, C.T. Okamoto, D.W. Warren, R.L. Wood, M. Bachmann, and A.K. Mircheff. Stimulation with carbachol alters endomembrane distribution and plasma membrane expression of intracellular proteins in lacrimal acinar cells. Exp Eye Res. 69:651 (1999a).
T. Yang, H. Zeng, J. Zhang, C.T. Okamoto, D.W. Warren, R.L. Wood, M. Bachmann, and A.K. Mircheff. MHC class II molecules, cathepsins, and La/SSb proteins in lacrimal acinar cell endomembranes. Am J Physiol. 277:C994 (1999b).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Kluwer Academic/Plenum Publishers
About this chapter
Cite this chapter
Mircheff, A.K., Qian, L., Xie, J., Wang, Y., Hamm-Alvarez, S.F. (2002). M3 Receptor Autoimmunity: Losing Tolerance to a Familiar Protein. In: Sullivan, D.A., Stern, M.E., Tsubota, K., Dartt, D.A., Sullivan, R.M., Bromberg, B.B. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. Advances in Experimental Medicine and Biology, vol 506. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0717-8_6
Download citation
DOI: https://doi.org/10.1007/978-1-4615-0717-8_6
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5208-2
Online ISBN: 978-1-4615-0717-8
eBook Packages: Springer Book Archive