Abstract
Water movement in the lacrimal gland is a consequence of ion channel and transporter activity. The production of tears is a consequence of acetylcholine (Ach) stimulation of acinar and duct cells, which produce a transepithelial flux of ions resulting in fluid movement. Ach acts through phospholipase C via Gq/11 and subsequently results in elevation of intracellular IP3 and DAG. The former raises intracellular calcium while the latter activates many PKC isoforms (Walcott, 1998; Dartt et al., 1998). In lacrimal gland K+, chloride and cation channels are activated by elevated intracellular calcium (Marty et al., 1984; Begenisich and Melvin, 1998).
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© 2002 Kluwer Academic/Plenum Publishers
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Brink, P.R., Valiunas, V., Moore, L., Birzgalis, A., Walcott, B. (2002). The Role of Gap Junctions in Lacrimal Acinar Cells: The Formation of Tears. In: Sullivan, D.A., Stern, M.E., Tsubota, K., Dartt, D.A., Sullivan, R.M., Bromberg, B.B. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. Advances in Experimental Medicine and Biology, vol 506. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0717-8_14
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DOI: https://doi.org/10.1007/978-1-4615-0717-8_14
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