Abstract
The exorbital lacrimal glands secrete the aqueous component of the tear film that consists mainly of water, electrolytes and proteins.1 Lacrimal protein output and fluid secretion are regulated by the autonomic nerves that innervate the acini, ducts and blood vessels.2 In a previous study we showed the typical serous acini of the lacrimal gland of young (3–5-month-old) male rats contained numerous protein secretory granules. Ageing was associated with a progressive loss of protein (from serous to seromucus and subsequently mucus acini). In addition, marked changes and patchy destruction of the endoplasmic reticulum and Golgi apparatus were observed in the acini of glands in aged rats when compared to that from young rats.3,4 Taken together, these observations suggest ageing may involve a derangement in lacrimal protein synthesis and release. This study investigates differences in secretagogue-evoked protein and peroxidase secretion and protein synthesis in male rat lacrimal acini.
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© 2002 Kluwer Academic/Plenum Publishers
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Singh, J., Draper, C.E., Adeghate, E.A. (2002). Effects of Ageing on Secretagogue-Evoked Protein Output, Peroxidase Secretion and Protein Synthesis in the Isolated Rat Lacrimal Gland. In: Sullivan, D.A., Stern, M.E., Tsubota, K., Dartt, D.A., Sullivan, R.M., Bromberg, B.B. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. Advances in Experimental Medicine and Biology, vol 506. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0717-8_12
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DOI: https://doi.org/10.1007/978-1-4615-0717-8_12
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5208-2
Online ISBN: 978-1-4615-0717-8
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