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Neuronal Nitric Oxide Synthase is Expressed in the Mouse Lacrimal Gland and Neurons of Pterygopalatine Ganglion

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Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3

Abstract

The mammalian lacrimal gland is densely innervated by parasympathetic and sympathetic nerves, as well as fibers that contain neuropeptides.1 The parasympathetic nerve fibers in the lacrimal gland arise from neurons in the pterygopalatine ganglion (PPG), a cranial parasympathetic ganglion that receives synaptic input from preganglionic parasympathetic neurons in the brainstem. PPG postganglionic axons innervate a variety of structures including the lacrimal gland, nasal and palatine mucosae, and cranial vasculature.2,3

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References

  1. B. Walcott, R.H. Cameron, and P.R. Brink, The anatomy and innervation of lacrimal glands. Adv Exp Med Biol. 350:11(1994).

    Article  CAS  PubMed  Google Scholar 

  2. H. Hara, Q J. Zhang, and T. Kuroyanagi, Parasympathetic cerebrovascular innervation: an anterograde tracing from the sphenopalatine ganglion in the rat. Neurosurgery. 32: 822(1993).

    Article  CAS  PubMed  Google Scholar 

  3. R. Uddman, L. Malm, and F. Sundler, The origin of vasoactive intestinal polypeptide (VIP) nerves in the feline nasal mucosa. Acta Otolaryngol. 89:152(1980).

    Article  CAS  PubMed  Google Scholar 

  4. C.F. Ibanez, M. Pelto-Huikko, and O. Soder, Expression of choline acetyltransferease mRNA in spermatogenic cells results in an accumulation of the enzyme in the postacrosomal region of mature spermatozoa. Proc Natl Acad Sci. USA, 88: 3676(1991).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. D. Wu, L.B. Hersh. Choline acetytransferase: Celebrating its fiftieth year. J Neurochem 62:1653(1994).

    Article  CAS  PubMed  Google Scholar 

  6. U. Arvidsson, M. Riedl, and R. Elde, Vesicular acetylcholine transporter (VAChT) protein: a novel and unique marker for cholinergic neurons in the central and peripheral nervous systems. J Comp Neurol. 378:454(1997).

    Article  CAS  PubMed  Google Scholar 

  7. V.L. Dawson, T.M. Dawson. Nitric oxide in neurodegeneration. Prog Brain Res. 118: 215(1998).

    Article  CAS  PubMed  Google Scholar 

  8. T. Hanazawa, K. Tanaka, and T. Chiba, Distribution and origin of nitric oxide synthase-containing nerve fibers in human nasal mucosa. Acta Otolaryngol. 117: 735(1997).

    Article  CAS  PubMed  Google Scholar 

  9. S.H. Lee, T. Iwanaga, and O. Hoshi, Nitric oxide synthase in rat nasal mucosa; immunohistochemical and histochemical localization. Acta Otolaryngol. 115: 823(1995).

    Article  CAS  PubMed  Google Scholar 

  10. H. Matsuda, T. Kusakabe, and T. Kawakami. Coexistence of nitric oxide synthase and neuropeptides in the mouse vomeronasal organ demonstrated by a combination of double immunofluorescence labeling and a multiple dye filter. Brain Res. 712: 35(1996).

    Article  CAS  PubMed  Google Scholar 

  11. B.S. Zhu, I.L. Gibbins, W.W. Blessing. Preganglionic parasympathetic neurons projecting to the sphenopalatine ganglion contain nitric oxide synthase in the rabbit. Brain Res. 769:168(1997).

    Article  CAS  PubMed  Google Scholar 

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© 2002 Kluwer Academic/Plenum Publishers

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Ding, C., Walcott, B., Keyser, K.T. (2002). Neuronal Nitric Oxide Synthase is Expressed in the Mouse Lacrimal Gland and Neurons of Pterygopalatine Ganglion. In: Sullivan, D.A., Stern, M.E., Tsubota, K., Dartt, D.A., Sullivan, R.M., Bromberg, B.B. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. Advances in Experimental Medicine and Biology, vol 506. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0717-8_11

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  • DOI: https://doi.org/10.1007/978-1-4615-0717-8_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5208-2

  • Online ISBN: 978-1-4615-0717-8

  • eBook Packages: Springer Book Archive

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