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Somatostatin-Like Immunoreactivity (SLIR) in Rat Harderian and Meibomian Glands and Glands of Zeis

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Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 506))

Abstract

In many species serous lacrimal glands bind sex hormones and prolactin, have cells making immunoglobulins and growth factors, and contain nerve fibers having peptides such as VIP, NPY, and Substance P.1 Because the latter neuropeptides also occur in the sebaceous meibomian gland,2 the present study sought to determine the possible presence and cellular localization of somatostatin (SOM) in the three lipid-containing3, 4 lacrimal glands of the rat. Its existence might affect neuroendocrine-immune system interactions,5 presumably diminishing them because SOM inhibits lymphocyte proliferation.6

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References

  1. D.A. Dartt and D.A. Sullivan, Wetting of the ocular surface, in: Principles and Practice of Ophthalmology, 2nd ed., D.M. Albert and F.A. Jakobiec, eds., W.B. Saunders, Philadelphia (2000), 960.

    Google Scholar 

  2. P. Seifert, and M. Spitznas, Immunocytochemical and ultrastructural evaluation of the distribution of nervous tissue and neuropeptides in the meibomian gland. Graefs Arch. Clin. Exp. Ophthalmol. 234:648 (1996).

    Article  CAS  Google Scholar 

  3. J. Olcese, and A. Wesche, The harderian gland. Comp. Biochem. Physiol A. 93:655 (1989).

    Article  CAS  PubMed  Google Scholar 

  4. J.M. Tiffany, Physiological functions of the meibomian glands. Prog. Retinal Eye Res. 14:47 (1995).

    Article  CAS  Google Scholar 

  5. R.L. Wilder, Neuroendocrine-immune system interactions and autoimmunity. Annu. Rev. Immunol. 13:307 (1995).

    Article  CAS  PubMed  Google Scholar 

  6. F. Homo-Delarche and S. Durant, Hormones, neurotransmitters and neuropeptides as modulators of lymphocyte functions, in: Immunopharmacology of Lymphocytes. M. Rola-Pleszczynski, ed., Academic Press, London (1994), 169.

    Google Scholar 

  7. J.V. Jester, N. Nicolaides, and R.E. Smith, Meibomian gland studies: histologic and ultrastructural investigations. Invest. Ophthalmol. Vis. Sci. 20:537 (1981).

    CAS  PubMed  Google Scholar 

  8. W. Montagna, and D. M. Ford, Histology and cytochemistry of human skin. XXXIII. The eyelid. Arch. Dermatol. 100:328 (1969).

    Article  CAS  PubMed  Google Scholar 

  9. N. Ehlers, The precorneal film. Acta Ophthalmol. 43 Suppll:73 (1965).

    Google Scholar 

  10. H.M. Johnson, M.O. Downs, and C.H. Pontzer, Neuroendocrine peptide hormone regulation of immunity. Chem. Immunol. 52:49 (1992).

    Article  CAS  PubMed  Google Scholar 

  11. Y. Chowers, L. Cahalon, M. Lahav, H. Schor, R. Tal, S. Bar-Meir, and M. Lévite, Somatostatin through its specific receptor inhibits spontaneous and TNF-_- and bacteria-induced IL-8 and IL-1 secretion from intestinal epithelial cells. J. Immunol. 165:2955 (2000).

    Article  CAS  PubMed  Google Scholar 

  12. I.S. Gottesman, L.J. Mandarino, and J.E. Gerich, Somatostatin: its role in health and disease. Spec. Top. Endocrinol. Metab. 4:177 (1982).

    CAS  PubMed  Google Scholar 

  13. J.B. Martin, L.P. Renaud, and P. Brazeau Jr, Pulsatile growth hormone secretion: suppression by hypothalamic ventromedial lesions and by long-acting somatostatin. Science 186:538 (1974).

    Article  CAS  PubMed  Google Scholar 

  14. N.F. Boas, and R.W. Bates, Role of the thyroid and anterior pituitary glands in the maintenance of the harderian glands of the rat. Endocrinology 55:601 (1954).

    Article  CAS  PubMed  Google Scholar 

  15. A.P. Payne, The harderian gland: a tercentennial review. J. Anat. 185 (Pt. 1) :1 (1994).

    PubMed  PubMed Central  Google Scholar 

  16. M.E. Mato, M. Puig-Domingo, O. Fornas, and S.M. Webb, Expression of the somatostatin gene and receptors in the rat harderian gland. Micr. Res. Technique 34:118 (1996).

    Article  CAS  Google Scholar 

  17. M.A. Peinado, N. Fajardo, G. Hernández, M. Puig-Domingo, M. Viader, R.J. Reiter, and S.M. Webb, Immunoreactive somatostatin diurnal rhythms in rat pineal, retina and harderian gland: effects of sex, season, continuous darkness and estrous cycle. J. Neural Transmission 81:63 (1990).

    Article  CAS  Google Scholar 

  18. E.S. Zyznar, A.O. Pietri, V. Harris, and R.H. Ungar, Evidence for the hormonal status of somatostatin in man. Diabetes 30:883 (1981).

    Article  CAS  PubMed  Google Scholar 

  19. S. Tsukahara and D.M. Jacobowitz, Peptidergic innervation of the rat Harderian gland. Histochemistry 87:233 (1987).

    Article  CAS  PubMed  Google Scholar 

  20. A. Schonbrunn and A.H. Tashjian Jr., Characterization of functional receptors for somatostatin in rat pituitary cells in culture. J. Biol. Chem. 253:6473 (1978).

    CAS  PubMed  Google Scholar 

  21. M. Azzarolo, A.K. Mircheff, R.L Kaswan, F.Z. Stanczyk, E. Gentschein, L. Becker, B. Nassir, and D.W. Warren, Androgen support of lacrimal gland function. Endocrine 6:39 (1997).

    Article  CAS  PubMed  Google Scholar 

  22. D. A. Dartt, M. Shulman, K.L. Gray, S.R. Rossi, C. Matkin, and J.P. Gilbard, Stimulation of rabbit lacrimal gland secretion with biologically active peptides. Am. J. Physiol. 254.G300 (1988).

    Google Scholar 

  23. D.A. Dartt, Signal transduction and control of lacrimal gland protein secretion: a review. Curr. Eye Res. 8:619 (1989).

    Article  CAS  PubMed  Google Scholar 

  24. M.T. Perra, M.S. Lantini, A. Serra, M. Cossu, G. De Martini, and P. Sirigu, Human meibomian glands: a histochemical study for androgen metabolic enzymes. Invest. Ophthalmol. Vis. Sci. 31:771 (1990).

    CAS  PubMed  Google Scholar 

  25. D.A. Sullivan, B.D. Sullivan, M.D. Ullman, E.M. Rocha, K.L. Krenzer, J.M. Cermak, I. Toda, M.G. Doane, J.E. Evans, and L.A. Wickham, Androgen influence on the meibomian gland. Invest. Ophthalmol. Vis. Sci. 41:3732 (2000).

    CAS  PubMed  Google Scholar 

  26. D.A. Sullivan, E.M. Rocha, M.D. Ullman, K.L. Krenzer, J. Gao, I. Toda, M.R. Dana, D. Bazzinotti, L. Aikawa da Silviera, and L.A. Wickham, Androgen regulation of the meibomian gland. Adv. Exp. Med. Biol. 438:327 (1998).

    Article  CAS  PubMed  Google Scholar 

  27. J.P. McCulley, and W.E. Shine, Meibomian secretions in chronic blepharitis. Adv. Exp. Med. Biol. 438:319(1998).

    Article  CAS  PubMed  Google Scholar 

  28. J.P. Gilbard, S.R. Rossi, and K. Gray Heyda, Tear film and ocular surface changes after closure of the meibomian gland orifices in the rabbit. Ophthalmology 96:1180 (1989).

    Article  CAS  PubMed  Google Scholar 

  29. M. A. Lemp, Report of the National Eye Institute/industry workshop on clinical trials in dry eyes. CIAO J. 21:221 (1995).

    CAS  Google Scholar 

  30. M.E. Stern, R.W. Beuerman, R.I. Fox, J. Gao, A.K. Mircheff, and S.C. Pflugfelder, The pathology of dry eye: the interaction between the ocular surface and lacrimal glands. Cornea 17:584 (1998).

    Article  CAS  PubMed  Google Scholar 

  31. D.A. Sullivan, Sex hormones and Sjögren’s syndrome. J. Rheumatol. 24 (Suppl. 50):17 (1997).

    Google Scholar 

  32. R.L. Font, Eyelids and lacrimal drainage system, in: Ophthalmic Pathology: An Atlas and Textbook. 4th ed., W.H. Spencer, ed., W.B. Saunders, Philadelphia (2000), 2353–2355.

    Google Scholar 

  33. G. Peluso, O. Petillo, M.A.B. Melone, G. Mazzarella, M. Ranieri, and G.F. Tajana, Modulation of cytokine production in activated human monocytes by somatostatin. Neuropeptides 30:443 (1996).

    Article  CAS  PubMed  Google Scholar 

  34. R. Scicchitano, P. Dazin, J. Bienenstock, D.G. Payan, and A.M. Stancsz, Distribution of somatostatin receptors on murine spleen and Peyer’s patch T and B lymphocytes. Brain Behav. Immunity 1: 173 (1987).

    Article  CAS  Google Scholar 

  35. M. Levite, Neuropeptides, by direct interaction with T cells, induce cytokine secretion and break the commitment to a distinct T helper phenotype. Proc. Nat’l. Acad. Sci. (U.S.A.) 95:12544 (1998).

    Article  CAS  Google Scholar 

  36. S.J. Bhathena, J. Louie, G.P. Schechter, R.S. Redman, L. Wahl, and L. Recant, Identification of human mononuclear leukocytes bearing receptors for somatostatin and glucagon. Diabetes 30:127 (1981).

    Article  CAS  PubMed  Google Scholar 

  37. E. Zierden, K. Hengst, and H. Wagner, Influence of somatostatin on peripheral leucocyte count and granulation tissue in man and rats. Hormones Metab. Res. 9:378 (1977).

    Article  CAS  Google Scholar 

  38. K. Yamashita, H. Kaneko, S. Yamamoto, T. Kongaya, K. Kusugami, and T. Mitsuma, Inhibitory effect of somatostatin on Helicobacter pylori proliferation in vitro. Gastroenterology 115:1123 (1998).

    Article  CAS  PubMed  Google Scholar 

  39. P.J. Driver, and M.A. Lemp, Meibomian gland dysfunction. Surv. Ophthalmol. 40:343 (1996).

    Article  CAS  PubMed  Google Scholar 

  40. D. LeRoith, W. Pickens, A.I. Vinik, and J. Shiloach, Bacillus subtilis contains multiple forms of somatostatin-like material. Biochem. Biophys. Res. Commun. 127:713 (1985).

    Article  CAS  PubMed  Google Scholar 

  41. D. LeRoith, W. Pickens, L.K. Crosby, M. Berelowitz, M. Holtgrefe, and J. Shiloach, Evidence for multiple molecular weight forms of somatostatin-like material in Escherichia coli. Biochim. Biophys. Acta 838:335 (1985).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Physiology & Biophysics, Georgetown University School of Medicine, Washington, D.C., USA

    Mortimer Lorber

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  1. Mortimer Lorber
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Editors and Affiliations

  1. Schepens Eye Research Institute, Boston, Massachusetts, USA

    David A. Sullivan , Darlene A. Dartt  & Rose M. Sullivan ,  & 

  2. Harvard Medical School, Boston, Massachusetts, USA

    David A. Sullivan  & Darlene A. Dartt  & 

  3. Allergan, Inc., Irvine, California, USA

    Michael E. Stern

  4. Tokyo Dental College, Chiba, Japan

    Kazuo Tsubota

  5. Ichikawa General Hospital, Chiba, Japan

    Kazuo Tsubota

  6. University of New Orleans, New Orleans, Louisiana, USA

    B. Britt Bromberg

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© 2002 Kluwer Academic/Plenum Publishers

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Lorber, M. (2002). Somatostatin-Like Immunoreactivity (SLIR) in Rat Harderian and Meibomian Glands and Glands of Zeis. In: Sullivan, D.A., Stern, M.E., Tsubota, K., Dartt, D.A., Sullivan, R.M., Bromberg, B.B. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. Advances in Experimental Medicine and Biology, vol 506. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0717-8_10

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  • DOI: https://doi.org/10.1007/978-1-4615-0717-8_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5208-2

  • Online ISBN: 978-1-4615-0717-8

  • eBook Packages: Springer Book Archive

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