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Substrate Down Regulation of 12-lipoxygenase in Human Platelets

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Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 507))

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Abstract

Lipoxygenases are non heme iron containing enzymes which catalyze dioxygenation of unsaturated fatty acids with the production of the corresponding hydroperoxides. The main mammalian lipoxygenases are classified with respect to the positional specificity of the oxygenation of arachidonic acidI. 12-Lipoxygenase (12-LO) from human platelets was the first mammalian lipoxygenase described2however, the biological significance of this pathway in platelets is not completely understood. Furthermore, little is known about regulation of 12-lipoxygenase activity in human platelets. It has been shown that 12-LO is activated by its product, 12-hydroperoxyeicosatetraenoic acid (12-HPETE)3.

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References

  1. S. Yamamoto, Mammalian lipoxygenases:molecular structures and functionsBiochint. Biophys. Acta.1128: 117 (1992).

    Article  CAS  Google Scholar 

  2. M. Hamberg, and B. Samuelsson, Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human plateletsProc. Natl. Acad. Sci. USA.71:3400 (1974).

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  3. M.1. Siegel, R.T. McConnell, S.L. Abrahams, N.A. Porter, and P. Cuatrecasas, Regulation of arachidonate metabolism via lipoxygenase and cyclo-oxygenase by 12-HPETE, the product of human platelet lipoxygenaseBiochem. Biophys. Res. Commun.89:1273 (1979).

    Article  CAS  PubMed  Google Scholar 

  4. R.L. Maas, and A.R. Brash, Evidence for a lipoxygenase mechanism in the biosynthesis of epoxide and dihydroxy leukotrienes from 15(S)-hydroperoxyicosatetraenoic acid by human platelets and porcine leukocytesProc. Natl. Acad. Sci. USA.80:2884 (1983).

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  5. J.Y. Vanderhoek, R.W. Bryant, and J. M. Bailey, 15-Hydroxy-5,8,11,13-eicosatetraenoic acid.A potent and selective inhibitor of platelet lipoxygenaseJ. Biol. Chem.255:5996 (1980).

    CAS  PubMed  Google Scholar 

  6. M. Dadaian, and P. Westlund, Albumin modifies the metabolism of hydroxyeicosatetraenoic acids via 12 lipoxygenase in human plateletsJ. Lipid Res.40:940 (1999).

    CAS  PubMed  Google Scholar 

  7. S.T. Prigge, J.C.Boyington, M. Faig, K.S. Doctor, B.J. Gaffney, and L.M. Amzel, Structure and mechanism of lipoxygenasesBiochimie.79:629 (1997).

    Google Scholar 

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Authors and Affiliations

  1. Department of Woman and Child Health Division of Reproductive Endocrinology, Karolinska Hospital, Bldg. L5, S-171 76, Stockholm, Sweden

    Marina Dadaian & Pär Westlund

Authors
  1. Marina Dadaian
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  2. Pär Westlund
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Editors and Affiliations

  1. Wayne State University, Detroit, Michigan, USA

    Kenneth V. Honn

  2. Vanderbilt University School of Medicine, Nashville, Tennessee, USA

    Lawrence J. Marnett

  3. Free University Berlin, Berlin, Germany

    Santosh Nigam

  4. University of California-San Diego, La Jolla, California, USA

    Edward Dennis

  5. Brigham and Women’s Hospital, Boston, Massachusetts, USA

    Charles Serhan

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© 2002 Springer Science+Business Media New York

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Dadaian, M., Westlund, P. (2002). Substrate Down Regulation of 12-lipoxygenase in Human Platelets. In: Honn, K.V., Marnett, L.J., Nigam, S., Dennis, E., Serhan, C. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5. Advances in Experimental Medicine and Biology, vol 507. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0193-0_18

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  • DOI: https://doi.org/10.1007/978-1-4615-0193-0_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4960-0

  • Online ISBN: 978-1-4615-0193-0

  • eBook Packages: Springer Book Archive

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