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Endothelial COX-2 induction by hypoxia liberates 6-keto-PGF1α, a potent epithelial Secretagogue

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Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 507))

Abstract

Mucosal epithelial cells provide a barrier that separates lumenal and vascular compartments. This monolayer of cells provides barrier function and serves as a conduit for vectorial ion movement, the transport event underlying mucosal hydration1. By secreting solutes and transporting fluid, epithelial cells are able to coordinate compositional changes of the luminal compartment. A number of stimuli, including hormones, neurotransmitters and cytokines have been shown to directly regulate epithelial function1-3

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Author information

Authors and Affiliations

  1. Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women’s Hospital, Boston, MA, 02115

    Sean P. Colgan, Cormac T. Taylor, Sailaja Narravula & Kristin Synnestvedt

  2. Department of Cardiology, Children’s Hospital and Harvard Medical School, Boston, MA, 02115

    Elizabeth D. Blume

Authors
  1. Sean P. Colgan
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  2. Cormac T. Taylor
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  3. Sailaja Narravula
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  4. Kristin Synnestvedt
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  5. Elizabeth D. Blume
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Editor information

Editors and Affiliations

  1. Wayne State University, Detroit, Michigan, USA

    Kenneth V. Honn

  2. Vanderbilt University School of Medicine, Nashville, Tennessee, USA

    Lawrence J. Marnett

  3. Free University Berlin, Berlin, Germany

    Santosh Nigam

  4. University of California-San Diego, La Jolla, California, USA

    Edward Dennis

  5. Brigham and Women’s Hospital, Boston, Massachusetts, USA

    Charles Serhan

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© 2002 Springer Science+Business Media New York

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Colgan, S.P., Taylor, C.T., Narravula, S., Synnestvedt, K., Blume, E.D. (2002). Endothelial COX-2 induction by hypoxia liberates 6-keto-PGF1α, a potent epithelial Secretagogue. In: Honn, K.V., Marnett, L.J., Nigam, S., Dennis, E., Serhan, C. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5. Advances in Experimental Medicine and Biology, vol 507. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0193-0_17

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  • DOI: https://doi.org/10.1007/978-1-4615-0193-0_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4960-0

  • Online ISBN: 978-1-4615-0193-0

  • eBook Packages: Springer Book Archive

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