Abstract
Proteinuria is a major cause of morbidity in patients with glomerular disease. Nonselective protein filtration is now recognized as a significant contributing factor to the tubulo-interstitial injury which underlies and often predicts progressive renal insufficiency in patients with primary glomerular diseases. Increasing recognition of the mechanisms whereby proteinuria leads to tubule injury confirms the well-known clinical observation that the magnitude of proteinuria at diagnosis is a reliable predictor of prognosis in patients with glomerulonephritis and diabetes. For this reason, the search for safe and effective anti-proteinuric agents which do not reduce the glomerular filtration rate represents an urgent and critical need for physicians involved in the care of patients with glomerular disorders.
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Valdivielso, J.M., Montero, A., Munger, K.A., Badr, K.F. (2002). Inhibition of 5-lo Activating Protein (Flap) Activity Decreases Proteinuria in Streptozotocin(Stz)-induced Diabetic Rats.. In: Honn, K.V., Marnett, L.J., Nigam, S., Dennis, E., Serhan, C. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5. Advances in Experimental Medicine and Biology, vol 507. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0193-0_13
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DOI: https://doi.org/10.1007/978-1-4615-0193-0_13
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