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Metabolism and Transportation Pathways Of GDP-Fucose that are Required for the O-Fucosylation Of Notch

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Notch Signaling in Embryology and Cancer

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 727))

Abstract

Notch is a single-pass transmembrane receptor that mediates the local cell-cell interactions necessary for many cell-fate decisions. The extra cellular domain of Notch contains a tandem array of epidermal growth factor-like (EGF-like) repeats. Some of these EGF-like repeats are O-fucosylated by protein O-fucosyltransferase 1 (O-fut1), which is essential for Notch signaling in Drosophila and mouse. This O-fucose is further modified by Fringe, a GlcNAc transferase and other glycosyltransferases (O-fut1 in Drosophila and Pofut1 in mouse), to form an O-linked tetrasaccharide, which modulates Notch’s selective binding to its ligands

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Authors and Affiliations

  1. Department of Biological Science and Technology, Tokyo University of Science, Noda, Chiba, Japan

    Tomoko Yamakawa, Tomonori Ayukawa & Kenji Matsuno

Authors
  1. Tomoko Yamakawa
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  2. Tomonori Ayukawa
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  3. Kenji Matsuno
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Corresponding author

Correspondence to Kenji Matsuno .

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Editors and Affiliations

  1. Department of Dermatology, The Saarland University Hospital, Homburg, Germany

    Jörg Reichrath

  2. Department of Internal Medicine I, The Saarland University Hospital, Homburg, Germany

    Sandra Reichrath

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Yamakawa, T., Ayukawa, T., Matsuno, K. (2012). Metabolism and Transportation Pathways Of GDP-Fucose that are Required for the O-Fucosylation Of Notch. In: Reichrath, J., Reichrath, S. (eds) Notch Signaling in Embryology and Cancer. Advances in Experimental Medicine and Biology, vol 727. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0899-4_3

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