Abstract
The peritoneal cavity is vulnerable to the implantation of cancer cells that have escaped from a primary tumor into the peritoneal cavity. Although peritoneal metastases have been assumed classically to occur at random in every portion of the peritoneal membrane, they actually occur at anatomically or physiologically preferred sites, such as the greater omentum, diaphragm, and pelvic peritoneum [1]. An important function of the peritoneum is associated with the lymphatic system of the peritoneal cavity that helps to maintain its homeostasis [2]. In the greater omentum there are many omentum-associated lymphoid tissues (OALT), known as milky spots. The OALT acts a filter through which lymph and various substances are rapidly taken up, and it participates in the immune defense of the peritoneal cavity [3]. The OALT also plays an important role in the initial stages of peritoneal carcinomatosis.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Willis RA. The Spread of Tumors in the Human Body, 3rd ed. London: Butterworths, 1973, pp 49–52.
Yoffey JM, Courtice FC. Lymph flow from regional lymphaticus. XV The peritoneal and pleural cavities. In Yoffey JM, Courtice FC, eds. Lymph, Lymphaticus and the Lymphomyeloid Complex. London: Academic Press, 1970, pp 295–309.
Shimotsuma M, Shields JW, Simpson-Morgan MW, et al. Morpho-physiological function and role of omental milky spots as omentum-associated lymphoid tissue (OALT) in the peritoneal cavity. Lymphology 1993;26:90–101.
Shimotsuma M, Kawata M, Hagiwara A, Takahashi T. Milky spots in the human greater omentum: Its macroscopic and histological identification. Acta Anat 1989;136:211–216.
Borisov A. Lymphatic capillaries and vessels of milky spots in human great omentum. Arkh Anat Gistol Embriol 1963;44:150–154.
Shimotsuma M, Simpson-Morgan MW, Takahashi T, Hagiwara A. Activation of omental milky spots and milky spot macrophages by intraperitoneal administration of a streptococcal preparation, OK-432. Cancer Res 1992;52:5400–5402.
Dux K. Role of the greater omentum in the immunological response of mice and rats to the intraperitoneal inoculation of Ehrlich ascites tumor. Arch Immunol Ther Exp 1969;17: 425–432.
Tobai S, Kawaguchi T, Asahina S, Nakamura K. Some findings of the intravasation of Yoshida sarcoma cells in the omentum. Gann 1980;71:578–579.
Green J, Williams AE. The relationship between inflammatory responses and WBP1 tumor cells attachment to the rat omentum. Eur J Cancer 1978;14:1153–1155.
Hagiwara A, Takahashi T, Sawai K, et al. Milky spots as the implantation site for malignant cells in peritoneal dissemination in mice. Cancer Res 1993;53:687–692.
Shimotsuma M, Itoh M, Sasabe T, et al. Role of omental milky spots in peritoneal metastasis of carcinoma. Oncologia 1991;24:80–85.
Sampson JA. The origin and significance of newly formed lymph vessels in carcinomatous peritoneal implants. Am J Pathol 1936;12:432–467.
Shimotsuma M, Hagiwara A, Takahashi T, Kawata M, Shields JW. Surface structure and cell zonation in human omental milky spots. Lymphology 1990;23:207–208.
Hodel C. Ultrastructural studies on the absorption of protein markers by the greater omentum. Eur Surg Res 1970;2:435–449.
Cranshaw ML, Leak LV. Milky spots of the omentum: A source of peritoneal cells in the normal and stimulated animal. Arch Histol Cytol 1990;53:165–177.
Lawrance RJ, Loizidou M, Cooper AJ, Alexander P, Taylor I. Importance of the omentum in the development of intra-abdominal metastases. Br J Surg 1991;78:117–119.
Folkman J. Anti-angiogenesis: New concept for therapy of solid tumors. Ann Surg 1972; 175:409–416.
Goldsmith HS, Griffin AL, Kupfermann A. Lipid angiogenetic factor from the omentum. JAMA 1984;252:2034–2036.
Holm-Nielsen P. Pathogenesis of ascites in peritoneal carcinomatosis. Acta Pathol Microbiol Scand 1953;33:10–21.
Shimotsuma M, Shirasu M, Hagiwara A, Takahashi T, Shields JW. Omental milky spots and the local immune response. Lancet 1992;339:1232.
Shimotsuma M, Sakuyama A, Shirasu M, Hagiwara A, Takahashi T. The role of the lymphatic system of the greater omentum and diaphragm in intraperitoneal cancer dissemination. Jpn J Lymphol 1993;16:1–11.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Kluwer Academic Publishers, Boston
About this chapter
Cite this chapter
Shimotsuma, M., Shirasu, M., Hagiwara, A., Takahashi, T. (1996). Role of omentum-associated lymphoid tissue in the progression of peritoneal carcinomatosis. In: Sugarbaker, P.H. (eds) Peritoneal Carcinomatosis: Principles of Management. Cancer Treatment and Research, vol 82. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1247-5_9
Download citation
DOI: https://doi.org/10.1007/978-1-4613-1247-5_9
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-8531-1
Online ISBN: 978-1-4613-1247-5
eBook Packages: Springer Book Archive