Skip to main content

Mitochondrial Nephrology

  • Chapter
Mitochondrial Medicine

Mitochondrial defects play an important role in the pathogenesis of tubular syndromes, interstitial nephritis, focal and segmental glomerulosclerosis and diabetic nephropathy. The role of mitochondria in the pathogenesis of nephrotoxicity and kidney carcinogenesis is also discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. www.biowebgym.szm.sk (in Slovak)

  2. www.le.ac.uk

  3. www.nda.ox.ac.uk

  4. Birkus G, Hajek M, Kramata P, Votruba I, Holy A, Otova B (2002) Tenofovir diphosphate is a poor substrate and a weak inhibitor of rat DNA polymerase α, δ, ε. Antimicrob Agents Chemother 46:1610–1613

    Article  PubMed  CAS  Google Scholar 

  5. Bonvalet JP, Pradelles P, Farman N (1987) Segmental synthesis and actions of prostaglandins along the nephron. Am J Physiol 253:F377–387

    PubMed  CAS  Google Scholar 

  6. Boute N, Gribouval O, Roselli S, Benessy F, Lee H, Fuchahuber J, Dahan K, Gubler MC, Niaudet P, Antignac C (2000) NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome. Nat Genet 24:349–54

    Article  PubMed  CAS  Google Scholar 

  7. Brenes LG, Sanchez MI (1993) Impaired urinary ammonium excretion in patients with isolated proximal renal tubular acidosis. J Am Soc Nephrol 4:1073–1078

    PubMed  CAS  Google Scholar 

  8. Buemi M, Allegra A, Rotig A, Gubler MC, Aloisi C, Corica F, Pettinatto G, Frisina N, Niaudet P (1997) Renal failure from mitochondrial cytopathies. Nephron 76:249–253

    Article  PubMed  CAS  Google Scholar 

  9. Cengiz K, Block AW, Hossfeld DK et al. (1988) Sister chromatid exchange and chromosome abnormalities in uremic patients. Cancer Genet Cytogenet 36:55–67

    Article  PubMed  CAS  Google Scholar 

  10. Coté HCF, Magil AB, Harris M, Scarth BJ, Gadawski I, Wang NY, Yu E, Yip B, Zalunardo N, Werb, Hogg RS, Harrigan PR, Montaner JS (2005) Mitochondrial nephrotoxicity, a potential mechanism of kidney dysfunction in HIV-infected patients on HAART. Antivir Ther 10:L12

    Google Scholar 

  11. Dass PD, Martin D (1990) Adaptive ammoniagenesis in chronic renal failure. Ren Physiol Biochem 13:259–263

    PubMed  CAS  Google Scholar 

  12. De Jong AMP, Albracht SPJ (1994) Ubisemiquinones as obligatory intermediates in the electron transfer from NADH to ubiquinone. Eur J Biochem 222:975–982

    Article  PubMed  Google Scholar 

  13. Dinour D, Mini S, Polak-Charcon S, Lotan D, Holtzman EJ (2004) Progressive nephropathy associated with mitochondrial tRNA gene mutation. Clin Nephrol 62:149–154

    PubMed  CAS  Google Scholar 

  14. Djouadi F, Bastin J, Gilbert T et al. (1994) Mitochondrial biogenesis and development of respiratory chain enzymes in kidney cells: role of glucocorticoids. Am J Physiol 245–254

    Google Scholar 

  15. Doleiris LM, Hill GS, Chedin P, Nochy D, Bellanne-Chantelot C, Hanslik T, Bedrossian J, Caillat-Zucman S, Cahen-Varsaux H, Bariety J (2000) Focal segmental glomerulosclerosis associated with mitochondrial cytopathy. Kidney Int 58:1851–1858

    Article  Google Scholar 

  16. Dusso AS, Brown AJ, Slatopolsky E (2005) Vitamin D. Am J Physiol Renal Physiol 289:F8–F28

    Article  PubMed  CAS  Google Scholar 

  17. Dzúrik R, Gazdíková K, Štefíková K, Spustová V (2000) Nephrologic manifestations of mitochondrial diseases. Cas Lek Cesk 139:38–41 (in Slovak)

    PubMed  Google Scholar 

  18. Eviatar EA, DiMauro S (1990) Kearns-Sayre syndrome presenting as renal tubular acidosis. Neurology 40:1761–1763

    PubMed  CAS  Google Scholar 

  19. Foli A, Benvenuto F, Piccinini G, Bareggi A, Cossarizza A, Lisziewicz J, Lori F (2001) Direct analysis of mitochondrial toxicity of antiretroviral drugs. AIDS 15:1687–1694

    Article  PubMed  CAS  Google Scholar 

  20. Friedman J, Levi J, Malachi T, Slor H (1988) Pronounced depressed ability of DNA repair in uremic lymphocytes. Transplantation 45:665–666

    Article  PubMed  CAS  Google Scholar 

  21. Gazdikova K, Gvozdjakova A, Kucharska J, Spustova V, Braunova Z, Dzurik R (2001) Oxidative stress and plasma concentrations of coenzyme Q10, alpha-tocopherol, and beta-carotene in patients with a mild to moderate decrease of kidney function. Nephron 88(3):285

    Article  PubMed  CAS  Google Scholar 

  22. Gazdikova K, Gvozdjakova A, Kucharska J, Spustova V, Braunova Z, Dzurik R (2000) Malondialdehyde and selected antioxidant plasma levels in conservatively treated patients with kidney disease. BMJ 101:490–494

    CAS  Google Scholar 

  23. Gazdikova K, Gvozdjakova A, Kucharska J, Spustova V, Braunova Z, Dzurik R (2001) Effect of coenzyme Q10 in patients with kidney disease. Cas lek Cesk 140:307–310 (in Slovak)

    PubMed  CAS  Google Scholar 

  24. Gerbitz KD, van den Ouweland JM, Maassen JA, Jakch M (1995) Mitochondrial diabetes mellitus. A review. Biochim Biophys Acta 1271:253–260

    PubMed  Google Scholar 

  25. Goldenberg A, Ngoc LH, Thouret MC. Crmier-Daire V, Gagnadoux MF, Chretien D, Lafrancois C, Geromel V, Rotig A, Rustin P, Munnich A, Paquis V, Antignac C, Gubler MC, Niaudet P, de Lonlay P, Berard E (2005) Respiratory chain deficiency presenting as congenital nephrotic syndrome. Pediatr Nephrol 20:465–469

    PubMed  Google Scholar 

  26. Goto Y, Itami N, Kajii N, Tochimaru H, Endo M, Horai S (1990) Renal tubular involvement mimicking Bartter syndrome in a patient with Kearns-Sayre syndrome. J Pediatr 116:904–910

    Article  PubMed  CAS  Google Scholar 

  27. Grünfeld JP, Niaudet P, Rötig A (1996) Renal involvement in mitochondrial cytopathies. Nephrol Dial Transplant 11:760–761

    PubMed  Google Scholar 

  28. Gucer S, Talim B, Asan E, Korkusuz P, Ozen S, Unal S, Kalkanoglu SH, Kale G, Caglar M (2005) Focal segmental glomerulosclerosis associated with mitochondrial cytopathy: report of two cases with special emphasis on podocytes. Pediatr Dev Pathol 8:710–717

    Article  PubMed  Google Scholar 

  29. Guéry B, Choukroun G, Noël L, Clavel P, Röti A, Lebon S, Rustin P, Bellan-Chantelot Ch, Mougenot B, Grünfeld JP, Chauveau D (2003) The spectrum of systemic involvement in adults presenting with renal lesion and mitochodnrial tRNA(leu) gene mutation. J Am Soc Nephrol 14:2099–2108

    Article  PubMed  Google Scholar 

  30. Guillausseau PJ, Massin P, Dubois-LaForgue D, Timsit J, Virally M, Gin H, Bertin E, Blickle JF, Bouhanick B, Cahen J, Caillat-Zucman S, Charentier G, Chedin P, Derrie C, Ducluzeau PH, Grimaldi A, Guerci B, Kaloustain E, Murat A, Olivier F, Paques M, Paquis-Flucklinger V, Porokhov B, Samuel-Lajeunesse J, Vialettes B (2001) Maternally inherited diabetes and deafness: a muticenter study. Ann Intern Med 134:721–728

    PubMed  CAS  Google Scholar 

  31. Haguenauer A, Rainbaulr S, Masscheleyn S, del Mar Gonzalez-Barroso M, Criscuolo F, Plamondon J, Miroux B, Ricquier D, Richards D, Bouillaund F, Pecqueur C (2005) A new renal mitochondrial carrier, KMCP1, is up-regulated during tubular cell regeneration and induction of antioxidant enzymes. J Biol Chem 280:22036–22043

    Article  PubMed  CAS  Google Scholar 

  32. Hervuet E, Godinot C (2006) Mitochondrial disorders in renal tumors. Mitochondrion 6:105–117

    Article  Google Scholar 

  33. Hickey EJ, Raje RR, Reid VE, Gross SM, Day SD (2002) Diclofenac induced in vivo nephrotoxicity may involve oxidative stress-mediated massive genomic DNA fragmentation and apoptotic cell death. Free Radic Biol Med 31:139–152

    Article  Google Scholar 

  34. Hirano M, Konishi K, Arata N, Iyori M, Saruta T, Kuramochi S, Akizuki M (2002) Renal complications in a patient with A-to-G mutation of mitochondrial DNA at the 3243 position of leucine tRNA. Intern Med 41:113–118

    Article  PubMed  Google Scholar 

  35. Hotta O, Inoue CN, Miyabayashi F, Furuta T, Takeuchi A, Taguma Y(2001) Clinical and pathogenic features of focal segmental glomerulosclerosis with mitochondrial tRNA Leu(UUR) gene mutation. Kidney Int 59:1236–1243

    Article  PubMed  CAS  Google Scholar 

  36. Hsieh F, Gohh R, Dworkin L (1996) Acute renal failure and the MELAS syndrome, a mitochondrial encephalomyopathy. J Am Soc Nephrol 7:647–652

    PubMed  CAS  Google Scholar 

  37. Hwang S, Bohman R, Navas P, Norman JT, Bradley T, Fine LG (1990) Hypertrophy of renal mitochondria. J Am Soc Nephrol 1(5):822–7

    PubMed  CAS  Google Scholar 

  38. Iwasaki N, Babazono T, Tsuchiya K, Tomonaga O, Suzuki A, Togashi M, Ujihara N, Sakka Y, Yokokawa H, Ogata M, Nihei H, Iwamoto Y (2001) Prevalence of A-toG mutation at nucleotide 3243 of the mitochondrial tRNA (Leu/UUR) gene in Japanese patients with diabetes mellitus and end stage renal disease. J Hum Genet 46:330–334

    Article  PubMed  CAS  Google Scholar 

  39. Johnson AA, Ray AS, Hanes J, Suo Z, Colacino JM, Anderson KS, Johnson KA (2001) Toxicity of antiviral nucleoside analogs and the human mitochondrial DNA polymerase. J Biol Chem 276:40847–40857

    Article  PubMed  CAS  Google Scholar 

  40. Joza N, Susin SA, Daugas E, Stanfors WL, Cho SK, Li CY, Sasaki Y, Elia AJ, Cheng HY, Ravagnan L, Ferri KF, Zamzami N, Wakeham A, Hakem R, Yoshida H, Kong YY, Mak TW, Zuniga-Pflucker JC, Kroemer G, Penninger JM (2001) Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature (Lond) 410:549–554

    Article  PubMed  CAS  Google Scholar 

  41. Kahle W, Leonhardt H, Platzner W (1986) Internal Organs. Color Atlas/ Text of Human anatomy, Vol. 2. Thieme, New York, pp 362

    Google Scholar 

  42. Kaplan JM, Kim SH, North KN, Rennke H, Correia LA, Tong HQ, Mathis BJ, Rodriguez-Perezm JC, Allen PG, Begges A, Pollak MR (2000) Mutations in ACTN4, encoding α-actinin-4, cause familial focal segmental glomerulosclerosis. Nat genet 24:251–256

    Article  PubMed  CAS  Google Scholar 

  43. Katunuma N (1991) Role of glutamine and glutathion in terminal amino-nitrogen metabolism. Contrib Nephrol 92:1–12

    PubMed  CAS  Google Scholar 

  44. Kestila M, Lenkkeri U, Mannikko M, Lanmerdin J, McCready P, Putaala H, Routsalainen BV, Morita T, Nissinen M, Herva R, Kashtan CE, Peltonen L, Holmberg C, Olsen A, Tryggvason K (1998) Positionally cloned gene for a novel glomerular protein-nephrin– is mutated in congenital nephrotic syndrome. Mol Cell 1:575–582

    Article  PubMed  CAS  Google Scholar 

  45. Kiyomiya K, Matsuchita N, Kurebe M, Nakagawa H, Matsuo S (2002) Mitochondrial cytochrome c oxidase as a target site for cephalosporin antibiotics in renal epithelial cells (LLC-PK(1) ) and renal cortex. Life Sci 72:55–57

    Article  Google Scholar 

  46. Koo B, Becker LE, Chuang S et al. (1993) Mitochondrial encephalomyopathy, lactic acidosis, stroke-like episodes (MELAS): clinical, radiological, pathological, and genetic observations. Ann Neurol 34:25–32

    Article  PubMed  CAS  Google Scholar 

  47. Kvamme E, Roberg B, Torgner IA (1991) Effects of mitochondrial swelling and calcium on phosphate-activated glutaminase in pig renal mitochondria. Eur J Biochem 197:675–680

    Article  PubMed  CAS  Google Scholar 

  48. Lebrecht D, Setzer B, Rohbach R, Walker UA (2004) Mitochondrial DNA and its respiratory chain products are defective in doxorubicin nephrosis. Nephrol Dial Transplant 19:329–336

    Article  PubMed  CAS  Google Scholar 

  49. Lim P-S, Cheng Y-M, Wei Y-H (2000) Large-scale mitochondrial DNA deletions in skeletal muscle of patiets with end-stage renal disease. Free Radic Biol Med 29:454–463

    Article  PubMed  CAS  Google Scholar 

  50. Lippa S, Colacicco L, Bondanini F, Calla C, Gozzo ML, Ciccariello M, Angelitti AG (2000) Plasma levels of coenzyme Q(10), vitamin E and lipids in uremic patients on conservative therapy and hemodialysis treatment: some possible biochemical and clinical implementations. Clin Chim Acta 292:81–91

    Article  PubMed  CAS  Google Scholar 

  51. Lippa S, Colacicco L, Calla C, Sagliaschi G, Angelitti AG (1994) Coenzyme Q10 levels, plasma lipids and peroxidation extent in renal failure and in hemodialytic patients. Mol Aspects Med 15:213–219

    Article  Google Scholar 

  52. Liu CS, Kao SH, Wei YH (1997) Smoking-associated nmitochondrial DNA mutations in human hair follicles. Environ Mol Mutagen Biochem Mol Biol Int 42:285–298

    Google Scholar 

  53. Liu CS, Ko LY, Lim PS, Kao SH, Wei YH (2001) Biomarkers of DNA damage in patients with end-stage renal disease: mitochondrial DNA mutation in hair follicles. Nephrol Dial Transplant 16:561–565

    Article  PubMed  CAS  Google Scholar 

  54. Lopez LC, Schuelke M, Quinzii CM, Kanki T, Rodenburg RJ, Naini A, Dimauro S, Hirano M (2006) Leigh syndrome with nephropathy and CoQ10 deficiency due to decaprenyl diphosphate synthase subunit 2 (PDSS2) mutations. Am J Hum Genet 79:1125–1129

    Article  PubMed  CAS  Google Scholar 

  55. Majamaa K, Moilanen JS, Uimonen S, Remes AM, Salmela PI, Karppa M, Majamaa-Voltt KA, Rusanen H, Srri M, Peuhkurinen KJ, Hassinen IE (1998) Epidemiology of A3243G, the mutation for mitochondrial encephalomyopathy, lactic acidosis, and stroke like episodes: Prevalence of the mutation in an adult population. Am J Hum Genet 63:447–454

    Article  PubMed  CAS  Google Scholar 

  56. Majander A, Suomalainen A, Vettenranta K, Sariola H, Perkkio M, Holmberg C, Pihko H (1991) Congenital hypoplastic anemia, diabetes, and severe renal tubular dysfunction associated with a mitochondrial DNA deletion. Pediatr Res 30:327–331

    Article  PubMed  CAS  Google Scholar 

  57. Mályusz M, Hacki A, Wrigge P, Lange M, Malyusz T, Sick H, Gronow G (1994) Ammonia production from hippurate by the rat kidney in vitro. Renal Physiol 17:307–315

    Google Scholar 

  58. Martin-Hernandez E, Garcia-Silva MT, Vara J, Campos Y, Cabello A, Muley R, Del Hoyo P, Martin MA, Arenas J (2005) Renal pathology in children with mitochondrial diseases. Pediatr Nephrol 20:1299–1305

    Article  PubMed  Google Scholar 

  59. Meierhofer D, Mayr JA, Foetschl U, Bergerm A, Fink K, Schmeller N, Hacker GW, Hauser-Kronberger C, Kofler B, Sperl W (2004) Decrease of mitochondrial DNA content and energy metabolism in renal cell carcinoma. Carcinogenesis 25:1005–1010

    Article  PubMed  CAS  Google Scholar 

  60. Mingatto FE, Sants AC, Uyemura SA, Jordani MC, Curti C (1996) In vitro interaction of non-steroidal anti-inflammatory drugs on oxidative phosphorylation of rat kidney mitochondria: respiration and ATP synthesis. Arch Biochem Biophys 334:303–308

    Article  PubMed  CAS  Google Scholar 

  61. Mochizuki H, Joh K, Kawame H, Imadachi, Nozaki H, Ohashi Z, Usui N Eto Y, Aizawa S (1996) Mitochondrial encephalomyopathies preceded by de Toni-Debre-Fanconi syndrome or focal segmenta glomerulosclerosis. Clin Nephrol 46:347–352

    PubMed  CAS  Google Scholar 

  62. Murphy MD, O’Hearnm M, Chou S (2003) Fatal lactic acidosis and acute renal failure after addition of tenofovir to an atiretroviral regimen containing didanosine. Clin Inf Dis 36:1082–1085

    Article  Google Scholar 

  63. Nagy A, Wilhelm M, Kovacs G (2003) Mutations of mtDNA in renal cell tumours arising in end-stage renal disease. J Pathol 199(2):237–42

    Article  PubMed  CAS  Google Scholar 

  64. Nakamura S, Yoshinari M, Doi Y, Yoshizumi H, Katafuchi R, Yokomizo Y, Nishiyama K, Wakisaka M, Fujishima M (1999) Renal complications in patients with diabetes mellitus associated with an A to G mutation of mitochondrial DNA at the 3243 position of leucine tRNA. Diabetes Res Clin Pract 44:183–189

    Article  PubMed  CAS  Google Scholar 

  65. Ng LE, Vincent AS, Halliwell B, Wong KP (2006) Action of diclofenac on kidney mitochondria and cells. Biochem Biophys Res Com 348:494–500

    Article  PubMed  CAS  Google Scholar 

  66. Nohl HA, Stolze K (1992) Hypotesis. Ubisemiquinones of the mitochondrial respiratory chain do not interact with molecular oxygen. Free Radic Res Commun 16:409–414

    Article  PubMed  CAS  Google Scholar 

  67. Ormos J, Zsurka G, Turi S, Ivanyi B (1999) Familial mitochondrial tubulointerstitial nephropathy. Nephrol Dial Transplant 14:785–786

    Article  PubMed  CAS  Google Scholar 

  68. Parvari R, Brodyansky I, Elpeleg O, Moses S, Landau D, Herhkovitz E (2001) A recessive contiguous gene depletion of chromosome 2p16 associated with cystinuria and mitochondrial disease. Am J Hum Genet 69:869–875

    Article  PubMed  CAS  Google Scholar 

  69. Robles NR, Calero R, Rengel M, Valderrabano F (1990) Hemodialysis and cancer. Nephron 54:271–272

    Article  PubMed  CAS  Google Scholar 

  70. Salviati L, Sacconi S, Murer L, Zacchello G, Franceschini L, Laverda AM, Basso G, Quinzii C, Angelini C, Hirano M, Naini AB, Navas P, DiMauro S, Montini G (2005) Infantile encephalomyopathy and nephropathy with CoQ10 deficiency: a CoQ10-responsive condition. Neurology 65:606–608

    Article  PubMed  CAS  Google Scholar 

  71. Sangkhathat S, Kusafuka T, Yoneda A, Kuroda S, Tanaka Y, Sakai N, Fukuzawa M (2005) Renal cell carcinoma in a pediatric patient with an inherited mitochondrial mutation. Pediatr Surg Int 21(9):745–748

    Article  PubMed  Google Scholar 

  72. Sasaki R, Mazuro S, Nagao M (2000) Erythropoietin: multiple physiological functions and regulation of biosynthesis. Biosc Bitech Biochem 64:1775–1793

    Article  CAS  Google Scholar 

  73. Scaglia F, Vogel H, Hawkins EP, Vladutiu GD, Liu LL, Wong LJ (2003) Novel homoplastic mutation in teh mitochondrial tRNA Tyr gene associated with atypical mitochondrial cytopathy presenting with focal segemental glomerulosclerosis. Am J Med Genet A 123:172–178

    Article  Google Scholar 

  74. Schoolwerth AC, Gesek FA (1990) Intramitochondrial pH and ammonia production in rat and dog kidney cortex. Miner Electrolyte Met 16:264–269

    CAS  Google Scholar 

  75. Silbernagel S, Scheller F (1986) Formation and excretion of NH3-NH4 +. New aspects of an old problem. Klin Wschr 64:862–870

    Article  Google Scholar 

  76. Solin ML, Pitkanen S, Taanman JW, Holthofer H (2000) Mitochondrial dysfunction in congenital nephrotic syndrome. Lab Invest 80:1227–1232

    Article  PubMed  CAS  Google Scholar 

  77. Spustová V, Krivošíková Z, Gavulová L, Gazdíková K, Dzúrik R (1997) Nephrogenic metabolic acidosis. Klin Biochem Metabol 3:170–175

    Google Scholar 

  78. Stacpoole P (1993) Lactic acidosis. Endocrinol Metab Clin North Am 22:221–245

    PubMed  CAS  Google Scholar 

  79. Suzuki S, Hinokio Y, Ohtomo M et al. (1998) The effects of coenzyme Q10 treatment on maternally inherited diabetes mellitus and deafness, and mitochondrial DNA 3243 (A to G) mutation. Diabetologia 41:584–588

    Article  PubMed  CAS  Google Scholar 

  80. Szabolcs MJ, Seigle R, Shanske S, Bonilla E, DiMauro S, D’Agati V (1994) Mitochondrial DNA deletion: A cause of chronic tubulointerstitial nephropathy. Kidney Int 45:188–196

    Article  Google Scholar 

  81. Takaki A, Jimi S, Segawa M, Hisano S, Takebayashi S, Iwasaki H (2004) Long-term cadmium exposure accelerates age-related mitochondrial changes in renal epithelial cells. Toxicology 2003:145–154

    Article  Google Scholar 

  82. Tanji N, Tanji K, Kambham N, Markowitz GS, Bell A, D’Agati VD (2001) Adefovir nephrotoxicity: Possible role of mitochondrial DNA depletion. Hum Pathol 32:734–740

    Article  PubMed  CAS  Google Scholar 

  83. Tannen RL, Sahai A (1990) Biochemical pathway and modulators of renal ammoniagenesis. Miner Electrolyte Metab 16:249–258

    PubMed  CAS  Google Scholar 

  84. Triolo L, Lippa S, Oradei A, De Sole P, Mori R (1994) Serum coenzyme Q10 in uremic patients on chronic hemodialysis. Nephron 66:153–156

    Article  PubMed  CAS  Google Scholar 

  85. Turrens JF, Boveris A (1980) Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria. Biochem J 191:421–427

    PubMed  CAS  Google Scholar 

  86. Tzen CY, Tsai JD, Wu TY, Chen BF, Chen ML, Lin SP, Chen SC (2001) Tubulointerstitial nephritis associated with a novel mitochondrial point mutation. Kidney Int 59:846–854

    Article  PubMed  CAS  Google Scholar 

  87. Van Biervliet JBGM, Bruinvis L, Ketting D, deBrec PK, Van der Heiden C, Wadman SK (1977) Hereditary mitochondrial myopathy with lactic aciduria, a de Toni-Fanconi.Debre syndrome, and a defective respiratory chain in voluntary striated muscles. Pediatr Res 11:1088–1090

    Article  PubMed  CAS  Google Scholar 

  88. Vinay P, Lemieux G, Gougoux A, Halperin M (1986) Regulation of glutamine metabolism in dog kidney in vivo. Kidney Int 29:68–9

    Article  PubMed  CAS  Google Scholar 

  89. Warburg O, Wind F, Neglers E (1930) In: Warburg O (ed.) Metabolism of Tumors. Constable, London pp 254–270

    Google Scholar 

  90. Watson B, Khan MA, Desmond RA, Bergman S (2001) Mitochodnrial DNA mutations in black Americans with hypertension-associated end-stage renal disease. Am J Kidney Dis 3:529–536

    Article  Google Scholar 

  91. Wei YH (1992) Mitochondria DNA alterations as aging associated molecular events. Mutat Res 275:145–155

    PubMed  CAS  Google Scholar 

  92. Yamagata K, Muro K, Usui J, Hagiwara M, Kai H, Arakawa Y, Shimizu Y, Tomida Ch, Hirayama K, Kobayashi M, Koyama A (2002) Mitochondrial DNA mutations in focal segmental glomerulosclerosis lesions. J Soc Nephrol 13:1816–1823

    Article  CAS  Google Scholar 

  93. Yamagata K, Tomida C, Umeyama K, Urakami K, Ishizu T, Hitrayama K, Gotoh M, Iitsuka, Takemura K, Kikuchi H, Nakamura H, Kobayashi M, Koyama A (2000) Prevalence of Japanese dialysis patients with an A-to-G mutation at nucleotide 3243 of the mitochondrial tRNA (Leu(UUR) ) gene. Nephrol Dial Transplant 15:385–388

    Article  PubMed  CAS  Google Scholar 

  94. Ying WZ, Sanders PW (2001) Cytochrome c mediates apoptosis in hypertensive nephrosclerosis in Dahl/Rapp rats. Kidney Int 59:662–672

    Article  PubMed  CAS  Google Scholar 

  95. Zsurka G, Ormos J, Ivanyi B, Turi S, Endreffy E, Magyari M, Sonkodi S, Venetianer P.: Mitochondrial mutation as a probable causative factor in familial progressive tubulointerstitial nephritis. Hum Genet 99:484–487

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer Science + Business Media B.V

About this chapter

Cite this chapter

Gazdíková, K., Gazdík, F. (2008). Mitochondrial Nephrology. In: Gvozdjáková, A. (eds) Mitochondrial Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6714-3_9

Download citation

  • DOI: https://doi.org/10.1007/978-1-4020-6714-3_9

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-1-4020-6713-6

  • Online ISBN: 978-1-4020-6714-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics