Skip to main content
SpringerLink
Log in

Mitochondrial Diabetology

  • Chapter
Mitochondrial Medicine

  • 1810 Accesses

Diabetes mellitus (DM) is a chronic disease caused by disorder of insulin secretion in pancreatic β-cells, and/or its effect in tissues. Insulin acts to lower blood glucose by stimulation of glucose transport to muscle and fat cells and inhibition of its generation in the liver. Insulin promotes storage of the polysaccharide glycogen in the liver and muscles and stimulates glycogen synthesis.

Classification of DM is based on etiopathogenic mechanisms. Type 1 (characterized by β-cell destruction), type 2 (resistance to insulin action), other specific forms (mitochondrial DM included) and pregnancy diabetes.

Chronic hyperglycemia destroys many organs: eyes, kidneys, nervous tissue, heart and blood vessels. These changes are manifested as chronic diabetic complications.

Insulin deficiency and resistance to insulin action lead not only to changes in the metabolism of saccharides but also of proteins and lipids. The main pathobiochemical mechanisms of these changes are: (a) glycation of proteins, lipids, lipoproteins and DNA, (b) oxidative stress induced by hyperglycemia, (c) elevated flux via polyolic metabolic pathway of glucose, (d) changes linked with insulin signal pathway.

Abnormalities in metabolism which are typical for DM influence also functions of mitochondria. Disbalance between oxidative and reductive forms of supporting redox system create conditions for dysfunction of terminal oxidation. Mitochondria are assumed to be the key location for free radical generation because of the higher potential of reduced forms in this system (NADH). There is also a correlation between lower respiratory function of mitochondria and glycation of proteins in Complex II in the respiratory chain.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Alberti KG, Zimmet PY (1998) Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus; provisional report of a WHO consultation. Diabet Med 15:539–553

    Article  PubMed  CAS  Google Scholar 

  2. Baynes JW (1991) Role of oxidative stress in development of complications in diabetes. Diabetes 40:205–212

    Article  Google Scholar 

  3. Baynes JW, Thorpe SR, Alderson NA, Chachich ME, Metz TO (2003) Pyridoxamine inhibits chemical modification of proteins by lipids in obese and diabetic rats: mechanism of action of pyridoxamine. In: Abstracts of the 18th International Diabetes Federation Congress, Paris, 24–29 August 2003

    Google Scholar 

  4. Beck-Nielsen H (1997) Clinical disorders of insulin resistance. In: Alberti KGMM, DeFronzo RA, Keen H, Zimmet P (eds) International Textbook of Diabetes Mellitus, Vol. 1. Wiley, New York, pp 531–550

    Google Scholar 

  5. Bennetd PH, Bogardus C, Tuomilehto J, Zimmet P (1997) Epidemiology and natural history of NIDDM: Non–obese and obese. In: Alberti KGMM, DeFronzo RA, Keen H, Zimmet P (eds) International Textbook of Diabetes Mellitus, Vol. 1. Wiley, New York, pp 147–176

    Google Scholar 

  6. Bierhaus A, Hofmann MA, Ziegler R, Nawroth PP (1998) AGEs and their interaction with AGE-receptors in vascular disease and diabetes mellitus; the AGE concept. Cardiovas Res 37:586–600

    Article  CAS  Google Scholar 

  7. Borch-Johnsen K, Deckert T (1997) Complications of diabetes. In: Alberti KGMM, DeFronzo RA, Keen H, Zimmet P (eds) International Textbook of Diabetes Mellitus, Vol. 2. Wiley, New York, pp 1213–1222

    Google Scholar 

  8. Brownlee M (1994) Glycation and diabetic complications. Diabetes 43:836–841

    PubMed  CAS  Google Scholar 

  9. Brownlee M., Vlassara H., Kooney A, Ulrich P, Cerami A (1986) Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking. Science 232(4758):1629–1632

    Article  PubMed  CAS  Google Scholar 

  10. Bucala R, Makita Z, Koschinsky T, Cerami A, Vlassara H (1993) Lipid advanced glycosylation: pathway for lipid oxidation in vivo. Proc Natl Acad Sci USA 90:6434–6438

    Article  PubMed  CAS  Google Scholar 

  11. Bucala R, Cerami A (1996) DNA-advanced glycosylation. In: Ikan R (ed.) The Maillard Reaction /Consequences for the Chemical and Life Sciences. Wiley, New York

    Google Scholar 

  12. Carnevale Schianca GP, Rossi A, Sainaghi PP, Maduli E, Bartoli E (2003) The significance of impaired fasting glucose vs. impaired glucose tolerance: importance of insulin secretion and resistance. Diabetic Care 26:1333–1337

    Article  Google Scholar 

  13. Coletta A, Amiconi G, Bellelli A, Bertollini A, Čársky J, Castagnola M, Condo S, Brunori M (1988) Alteration of T-state binding properties of naturally glycated hemoglobin HbA1c. J Mol Biol 203:233–239

    Article  PubMed  CAS  Google Scholar 

  14. Coughlan MT, Thorburn DR, Fukami K, Laskowski A, Thallas-Bonke V, Long DM, Brownlee M, Cooper ME, Forbes JM (2005) Renal intra-mitochondrial glycation drives deficiencies in the activity of manganase superoxide dismutase and complex I of the mitochondrial respiratory chain in diabetes. In: Abstracts of the 41st EASD Annual Meeting, Athens, 10–15 September 2005

    Google Scholar 

  15. Čársky J (1999) Vol’né radikály a diabetes mellitus. In: Ďuračková Z, Bergendi L’, Čársky J (eds) Vol’né radikály a antioxidanty v medicíne (II) Slovak Academic Press Bratislava (Free radicals and diabetes mellitus. In: Free Radicals and Antioxidants in Medicine. III. In Slovak)

    Google Scholar 

  16. Ditzel J, Anderson H, peters ND (1975) Oxygen affinity of hemoglobin and red cell 2, 3-diphosphoglycerate in childhood diabetes. Acta Pediatr Scand 64:355–361

    Article  CAS  Google Scholar 

  17. Dotta F, Eisenbarth G (1997) Aethiopathogenesis of type 1 diabetes in western society. In: Alberti KGMM, DeFronzo RA, Keen H, Zimmet P (eds) International Textbook of Diabetes Mellitus, Vol. 1. Wiley, New York, pp 107–127

    Google Scholar 

  18. Dyer DG, Dunn JE, Thorpe SR, Bailie KE, Lyons TJ, McCance DR, Baynes JW (1993) Accumulation of Maillard reaction products in skin collagen in diabetes and aging. J Clin Invest 91:2463–2469

    Article  PubMed  CAS  Google Scholar 

  19. Edelstein E, Brownlee M (1992) Mechanistic studies of advanced glycosylation end product inhibition by aminoguanidine. Diabetes 41:26–29

    Article  PubMed  CAS  Google Scholar 

  20. Ekoe JM (1997) Epidemiology and Etiopathogenesis of IDDM in other ethnic groups. In: Alberti KGMM, DeFronzo RA, Keen H, Zimmet P (eds) International Textbook of Diabetes Mellitus, Vol. 1. Wiley, New York, pp 129–146

    Google Scholar 

  21. Ferranini E, DeFronzo RA (1997) Insulin action in vivo: glucose metabolism. In: Alberti KGMM, DeFronzo RA, Keen H, Zimmet P (eds) International Textbook of Diabetes Mellitus, Vol. 1. Wiley, New York, pp 409–438

    Google Scholar 

  22. Forbes JM, Coughlan MT, Fukami K, Laskowski A, Thallas-Bonke V, Dinh D, Long DM, Brownlee M, Cooper ME, Thorburn DR (2005) Do extracellular (circulating or dietary) advanced glycation end products mediate mitochondrial dysfunction in the kidney. In: Abstracts of the 41st EASD Annual Meeting, Athens, 10–15 September 2005

    Google Scholar 

  23. Fu MX, Baynes JW (1994) Glycation, glycooxidation and cross-linking of collagen by glucose kinetics, mechanism and inhibition of late stages of the Maillard reaction. Diabetes 43:676–683

    Article  PubMed  CAS  Google Scholar 

  24. Fulcher GR, Walker M, Alberti KGMM (1997) The assessment of insulin action in vivo. In: Alberti KGMM, DeFronzo RA, Keen H, Zimmet P (eds) International Textbook of Diabetes Mellitus, Vol. 1. Wiley, New York, pp 513–529

    Google Scholar 

  25. Gašperíková D, Šeböková, Klimeš I (2004) Mitochondriálna DNA a diabetes. In: Kreze A, Langer P, Klimeš I, Stárka L, Payer J, Michálek J (eds) Všeobecná a klinická endokrinológia. Academic Electronic Press, Bratislava, pp 620–623 (Mitochodrial DNA and diabetes. In: General and Clinical Endocrinology. In Slovak)

    Google Scholar 

  26. Harris MI, Zimmet P (1997) Classification of diabetes mellitus and other categories of glucose intolerance. In: Alberti KGMM, DeFronzo RA, Keen H, Zimmet P (eds) International Textbook of Diabetes Mellitus, Vol. 1. Wiley, New York, pp 3–18

    Google Scholar 

  27. Hunt JV, Wolf SP (1991) Oxidative glycation and free radical production: a causal mechanism of diabetic complications. Free Radic Res Commun 12–13(1):115–123

    Article  PubMed  Google Scholar 

  28. Idris I, Gray S, Donnelly R (2001) Protein kinase C activation: isozyme-specific effects on metabolism and cardiovascular complications in diabetes. Diabetologia 44:659–673

    Article  PubMed  CAS  Google Scholar 

  29. Jain SK, Lim G (2001) Pyridoxine and pyridoxamine inhibits superoxide radicals and prevents lipid peroxidation, protein glycosylation and (Na +, K+)-ATP-ase activity reduction in high glucose-treated human erythrocytes. Free Radic Biol Med 30:232–237

    Article  PubMed  CAS  Google Scholar 

  30. Jakuš V, Hrnčiarová M, Čársky J, Krahulec B, Riedbrock N (1999) Inhibition of nonenzymatic protein glycation and lipid peroxidation by drugs with antioxidative activity. Life Sci 65:1991–1993

    Article  PubMed  Google Scholar 

  31. Keen H (1997) Diabetes Diagnosis. In: Alberti KGMM, DeFronzo RA, Keen H, Zimmet P (eds) International Textbook of Diabetes Mellitus, Vol. 1. Wiley, New York, pp 19–33

    Google Scholar 

  32. Kishimoto M, Hashiramoto M, Araki S, Ishida Y, Kazummi T, Kanda E, Kasuga M (1995) Diabetes mellitus carrying a mutation in the mitochondrial tRNA (Leu(UUR) ) gene. Diabetologia 38:193–200

    Article  PubMed  CAS  Google Scholar 

  33. Klimeš I, Šeböková E, Tkáč I (2004) Metabolický syndróm. In: Kreze A, Langer P, Klimeš I, Stárka L, Payer J, Michálek J (eds) Všeobecná a klinická endokrinológia. Academic Electronic Press, Bratislava, pp 610–613 (The metabolic syndrome. In: Genenral and Clinical Endocrinology. In Slovak)

    Google Scholar 

  34. Lee HK (2005) Mitochondria in diabetes mellitus. In: Berdanier CD (ed.) Mitochodria in Health and Disease. CRC Press, Taylor & Francis p 619

    Google Scholar 

  35. Lee AT, Cerami A (1989) Nonenzymatic glycosylation of DNA by reducing sugars. In. Baynes JW, Monnier VM (eds) Progress in Clinical and Biological Research, Vol. 304. Alan R Liss, New York

    Google Scholar 

  36. Lomezi M, Montisano DF, Toledo S, Barrieux A (1986) High glucose and DNA damage in endothelial cells. J Clin Invest 77:322–325

    Article  Google Scholar 

  37. Maasen JA, Hart LM, van Essen E (2004) Mitochondrial diabetes molecular mechanism and clinical presentation. Diabetes 53(Suppl 1):103–109

    Article  Google Scholar 

  38. Makita Z, Vlassara H, Rayfield E, Cartwright K, Friedman E, Rodby R, Cerami A, Bucala R (1992) Hemoglobin-AGE: Circulating marker of advanced glycosylation. Science 258:651–653

    Article  PubMed  CAS  Google Scholar 

  39. Martinka E (2004) Patogenéza diabetes mellitus 1. typu. In: Kreze A, Langer P, Klimeš I, Stárka L, Payer J, Michálek J (eds) Všeobecná a klinická endokrinológia. Academic Electronic Press, Bratislava, pp 610–613 (Pathogenesis of diabetes mellitus type I. In: General and Clinical Endocrinology. In Slovak)

    Google Scholar 

  40. Muchová J, Liptáková A, Országová Z, Garaiová I, Tisoň P, Čársky J, Ďuračková Z (1999) Antioxidant system in polymorphonuclear leukocytes of type 2 diabetes mellitus. Diabet Med 16:74–78

    Article  PubMed  Google Scholar 

  41. Muchová J, Liptáková A, Országová Z, Garaiová I, Tisoň P, Čársky J, Ďuračková Z (1999) Antioxidant system in polymorphonuclear leukocytes of type 2 diabetes mellitus. Diabet Med 16:74–78

    Article  PubMed  Google Scholar 

  42. Nagaraj RH, Prabhakaram M, Ortwerth BJ, Monnier VM (1994) Suppression of pentosidine formation in galactosaemic rat lens by an inhibitor of aldose reductase. Diabetes 43:580–586

    Article  PubMed  CAS  Google Scholar 

  43. Niwa T, Katsuzaki T, Miyazaki S, Miyazaki T, Ishizaki Y, Hayase F, Tatemichi N, Takei Y (1997) Immunohistochemical detection of imidazolone, a novel advanced glycation end product, in kidney and aortas of diabetic patients. J Clin Invest 99:1272–1280

    Article  PubMed  CAS  Google Scholar 

  44. Njoroge FG, Monnier VM (1989) The chemisttry of the Maillard reaction under physiological conditions: a revue. In: Baynes JW, Monnier VM (ed.) The Maillard Reaction in Aging, Diabetes and Nutrition. Alan R Liss, New York

    Google Scholar 

  45. Obrosova IG, Minchenko AG, Vasupuram R, White L, Abatan OI, Kumagai AK, Frank RN, Stevens MJ (2003) Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocin-diabetic rats. Diabetes 52:864–871

    Article  PubMed  CAS  Google Scholar 

  46. Person B, Hanson U, Lunell N-O (1997) Diabetes mellitus and pregnacy. In: Alberti KGMM, DeFronzo RA, Keen H, Zimmet P (eds) International Textbook of Diabetes Mellitus, Vol. 2. Wiley, New York, pp 1085–1102

    Google Scholar 

  47. Peters AL, Davidson MB (1997) Aging and diabetes. In: Alberti KGMM, DeFronzo RA, Keen H, Zimmet P (eds) International Textbook of Diabetes Mellitus, Vol. 2. Wiley, New York, pp 1103–1128

    Google Scholar 

  48. Petersen KF, Befroy D, Dufour S, Dziura J, Ariyan C, Rothman DL, DiPietro L, Cline GW, Shulman GI (2003) Mitochondrial dysfunction in the eldery: possible role in insulin resistance. Science 300:1140–1142

    Article  PubMed  CAS  Google Scholar 

  49. Průhová Š, Lebl J (2004) MODY Maturity onset diabetes of the young. In: Kreze A, Langer P, Klimeš I, Stárka L, Payer J, Michálek J (eds) Všeobecná a klinická endokrinológia. Academic Electronic Press, Bratislava, pp 614–619 (In: General Sand Clinical Endocrinology.)

    Google Scholar 

  50. Rabini RA, Galassi R, Staffolani R, Vasta M, Furnelli P, Mazzanti L (1993) Alterations in Na+, K+-ATPase activity and fluidity of erythrocyte membranes from relatives of insulin dependent diabetic patients. Diab Res 22:33–40

    CAS  Google Scholar 

  51. Rácz O, Šipulová A (2004) Patogenéza chronickych komplikácií. In: Kreze A, Langer P, Klimeš I, Stárka L, Payer J, Michálek J (eds) Všeobecná a klinická endokrinológia. Academic Electronic Press, Bratislava, pp 654–660. (Pathogenesis of chronic complications. In: General and Clinical Endocrinology. In Slovak)

    Google Scholar 

  52. Rahbar S, Yernini KK, Scott S, Gonzales N, Lalezari I (1999) Novel inhibitors of advanced glycation endproducts. Biochem Biophys Res Commun 262:651–656

    Article  PubMed  CAS  Google Scholar 

  53. Raskin P, Rosenstock J (1997) The genesis of diabetes complication: blood glucose and genetic susceptibility. In: Alberti KGMM, DeFronzo RA, Keen H, Zimmet P (eds) International Textbook of Diabetes Mellitus, Vol. 2. Wiley, New York, pp 1225–1244

    Google Scholar 

  54. Requena JR, Ahmed MU, Fountain CW, Degenhardt TP, Reddy S, Perey C, Lyons TJ, Jenkins AJ, Baynes JW, Thorpe SR (1997) Carboxymetylethanolamine, a biomarker of phospholipid modification during the Maillard reaction in vivo. J Biol Chem 272(28):17473–17479

    Article  PubMed  CAS  Google Scholar 

  55. Rosca MG, Mustata TG, Kinter MT, Ozdemir AM, Kern TS, Szweda LI, Brownlee M, Monnier VM, Weiss MF (2005) Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation. Am J Physiol Renal Physiol 289(2): 420–430

    Article  CAS  Google Scholar 

  56. Sajithlal GB, Chithra P, Chandrakasan G (1998) The role of metal-catalyzed oxidation in the formation of advanced glycation end products: an in vitro study on collagen. Free Radic Biol Med 25:265–269

    Article  PubMed  CAS  Google Scholar 

  57. Sakurai T, Kimura S, Nakano M, kimura H (1991) Oxidative modification of glycated low density lipoprotein in the presence of iron. Biochem Biophys Res Commun 177:433–439

    Article  PubMed  CAS  Google Scholar 

  58. Schmidt AM, Hori O, Cao R, Yan SD, Brett j, Wautier JL, Ogawa S, Kuwabara K, Matsumoto M, Stern D (1996) RAGE a novel cellular receptor for advanced glycation end products. Diabetes 45:77–80

    Article  Google Scholar 

  59. Simonson DC, Ronetti L, Giaccari A, DeFronzo RA (1997) Glucose toxicity. In: Alberti KGMM, DeFronzo RA, Keen H, Zimmet P (eds) International Textbook of Diabetes Mellitus, Vol. 1. Wiley, New York, pp 635–667

    Google Scholar 

  60. Singh R, Barden A, Mori T, Beilin L (2001) Advanced glycation end-products: a review. Diabetologia 44:126–129

    Article  Google Scholar 

  61. Suzuki S, Hinokio Y, Hirai S, Onoda M, Matsumoto M, Kawasaki H, Satoh Y, Akai H, Abe K (1994) Pancreatic β-cell secretory defect associated with mitochondrial point mutation of the tRNA (LEU(UUR) ) gene: a study in seven families with mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS). Diabetologia 37:818–825

    Article  PubMed  CAS  Google Scholar 

  62. Taguchi T, Sugiura M, Hamada Y, Miwa I (1999) Inhibition of advanced protein glycation by a Schiff base between aminoguanidine and pyridoxal. Eur J Pharmacol 378:283–289

    Article  PubMed  CAS  Google Scholar 

  63. Taniguchi N, Kinoshita N, Arai K, Iizuka S, Usui M, Naito K (1989) Inactivation of erythrocyte Cu-Zn-superoxide dismutase through nonenzymatic glycosylation. In: Baynes JW Monnier VM (eds) Progress in Clinical and Biological Research, Vol. 304. Alan R Liss, New York

    Google Scholar 

  64. Thorsby E, Ronningen KS (1992) Role of HLA genes in predisposition to develop insulin-dependent diabetes mellitus. Ann Med 24:523–531

    Article  PubMed  CAS  Google Scholar 

  65. Thornalley P (1999) The clinical significance of glycation. Clin Lab 45:263–273

    CAS  Google Scholar 

  66. Tošerová E (2004) Gravidita a diabetes. In: Kreze A, Langer P, Klimeš I, Stárka L, Payer J, Michálek J (eds) Všeobecná a klinická endokrinológia. Academic Electronic Press, Bratislava, pp 719–725 (Pregnancy and diabetes. In: General and Clinical Endocrinology. In Slovak)

    Google Scholar 

  67. Tull E, LaPorte RE (1997) Epidemiology of insulin dependent diabetes mellitus: Aproaches to study. In: Alberti KGMM, DeFronzo RA, Keen H, Zimmet P (eds) International Textbook of Diabetes Mellitus, Vol. 1. Wiley, New York, pp 99–105

    Google Scholar 

  68. Vadheim CM, Rotter JI (1997) Genetics of diabetes mellitus. In: Alberti KGMM, DeFronzo RA, Keen H, Zimmet P (eds) International Textbook of Diabetes Mellitus, Vol. 1. Wiley, New York, pp 31–98

    Google Scholar 

  69. Vertommen J, Van den Enden M, De Leeuw I (1994) Flavonoid treatment reduces glycation and lipid peroxidation in experimental diabetic rats. Phytother Res 8:430–432

    Article  CAS  Google Scholar 

  70. Vozár J (2004) História klasifikácia a diagnostika diabetu. In: Kréze A, Langer P, Klimeš I, Stárka L, Payer J, Michálek J (eds) Všeobecná a klinická endokrinológia. Academic Electronic Press, Bratislava, pp 567–576 (History, classification and diagnosis of diabetes. In: General and Clinical Endocrinology. In Slovak.)

    Google Scholar 

  71. Waczuliková I, Ziegelhoffer A, Országová Z, Čársky J (2002) Fluidising effect of resorcylidene aminoguanidine on sarcolemmal membranes in streptozotocin-diabetic rats: blunted adaptation of diabetic myocardium to Ca2+ overload. J Physiol Pharmacol 53:727–739

    PubMed  Google Scholar 

  72. Wels-Knecht KJ, Zyzak DV, Litchfield JF, Thorpe SR, Baynes JW (1995) Mechanism of autooxidative glycosylation – identification of glyoxal and arabinose as intermediates in the autooxidative modification of proteins by glucose. Biochemistry 34:3702–3709

    Article  Google Scholar 

  73. Wolff SP (1996) Free radicals and glycation theory. In: Ikan R (ed.) The Maillard Reaction (Consequences for the Chemical and Life Sciences). Wiley, New York, pp 74–88

    Google Scholar 

  74. Wolff SP, Yang ZY, Hunt JV (1991) Protein glycation and oxidative stress in diabetes mellitus and aging. Free Radic Biol Med 10:339–352

    Article  PubMed  CAS  Google Scholar 

  75. Yan SD, Stern D, Schmidt AM (1997) What’s the RAGE? The receptor for advanced glycation end products (RAGE) and the dark side of glucose. Eur J Clin Invest 27:179–181

    Article  PubMed  CAS  Google Scholar 

References

  1. Dias AS, Porawski M, Alonso M, Morroni N, Collado PS, Gonzales-Gallego J (2005) Quercetin decreases oxidative stress, NF-kB activation, and iNOS overexpression in liver of streptozotocin-induced diabetic rats. J Nutr 135:2299–2304

    PubMed  CAS  Google Scholar 

  2. Green K, Brand MD, Murphy MP (2004) Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes. Diabetes (Suppl 1):S110–S118

    Google Scholar 

  3. Gvozdjáková A, Kucharská J, Braunová Z, Kolesár P (1998) Beneficial effect of CoQ10 on the antioxidative status and metabolism of fats and sugars in diabetics patients. First Conference of the International Coenzyme Q 10 Association, Boston, 21–24 May 1998, abtract book pp 95–97

    Google Scholar 

  4. Gvozdjáková A, Kucharská J, Sumbalová Z, Zaušková P, Mlynárik V, Bystrický P, Uličná O, Vančová O, Singh RB (2002) Can coenzyme Q10 and omega-3 fatty acids protect damaged function of brain and heart mitochondria in diabetic rats? Third Conference of the International Coenzyme Q 10 Association, London, UK, 22–24 November 2002, abstract book pp 109–111

    Google Scholar 

  5. Gvozdjáková A, Kucharská J, Sumbalová Z, Uličná O, Vančová O, Božek P, Singh RB (2005) Coenzyme Q10 and omega-3-polyunsaturated fatty acids protect heart and brain mitochondria in diabetes. Mitochondrion 5(3):226–227. Mitochondrial Medicine, St. Louis, 14–19 June 2005

    Google Scholar 

  6. Inui K, Fukushima H, Tsakamato H et al. (1992) Mitochondrial encephalomyopathies with the mutation of the tRNA Leu(UUR) gene. J Pediatr 120:62–66

    Article  PubMed  CAS  Google Scholar 

  7. Kristal BS, Jackson CT, Chung H-Y, Matsuda M, Nguyen HD, Yu BP (1997) Defects at center P underlie diabetes-associated mitochondrial dysfunction. Free Radic Biol Med 22(5):823–833

    Article  PubMed  CAS  Google Scholar 

  8. Kucharská J, Braunová Z, Uličná O, Zlatoš L, Gvozdjáková A (2000) Deficit of coenyzme Q in heart and liver mitochondria of rats with streptozotocin-induced diabetes. Physiol Res 49:411–418

    PubMed  Google Scholar 

  9. Maechler P, Wollheim CB (2001) Mitochondrial function in normal and diabetic beta-cells. Nature 414(6865):807–812

    Article  PubMed  CAS  Google Scholar 

  10. Mohan IK, Das UN (2000) Effect of L-arginine-nitric oxide system on the metabolism of essential fatty acids in chemically induced diabetes mellitus. Prostaglandins Leucot Essent Fatty Acids 62(1):35–46

    Article  CAS  Google Scholar 

  11. Niaudet P, Rotig A (1997) The kidney in mitochondrial cytopathies. Kidney Int 51:1000–1007

    Article  PubMed  CAS  Google Scholar 

  12. Santos DL, Palmiera CM, Seica R, Dias J, Mesquita J, Moreno AJ, Santos MS (2003) Diabetes and mitochondrial oxidative stress: a study using heart mitochondria from the diabetic Goto-Kakizaki rat. Mol Cell Biochem 246(1–2):163–170

    Article  PubMed  CAS  Google Scholar 

  13. Sumbalová Z, Kucharská J, Kašparová S, Mlynárik V, Bystrický P, Božek P, Uličná O, Vančová O, Singh RB, Gvozdjáková A (2005) Brain energy metabolism in experimental chronic diabetes: effect of long-term administration of coenzyme Q10 and ω-3 polyunsaturated fatty acids. Biologia 60(Suppl 17):105–108

    Google Scholar 

  14. Ziefelhoffer A, Ravingerová T, Waczulíková I, Barančík M, Ferko M, Gvozdjáková A, Strnisková M, Šimončíková P (2004) Sarcolemma to mitochondria crosstalk in the diabetic heart: endogenous protection of cell energetics. J Mol Cell Cardiol 36:772–773

    Google Scholar 

References

  1. Gvozdjáková A, Kucharská J, Cornélissen G, Mikulecký M, Singh RB, Halberg F (2004) Variations in cardiac mitochondrial coenzyme Q10 and oxidative phosphorylation. Int J Cardiol 97, Suppl 2, S15. The 3rd International Congress on Cardiovascular Disease, Thaiwan, Taipei, November 26–28, 2004

    Google Scholar 

  2. Gvozdjáková A, Kucharská J, Cornélissen G, Mikulecký M, Singh RB, Halberg F (2005) Fourth Conference of the International Coenzyme Q 10 Association, Los Angeles, April 14–17, Abstract Book: 113–115

    Google Scholar 

  3. Gvozdjáková A, Kucharská J, Cornélissen G, Mikulecký M, Singh RB, Halberg F (2005) Heart mitochondrial coenzyme “Q10-chronome” and variations of oxidative phosphorylation in diabetic rats. Mitochondrial Medicine 2005, St. Louis, USA, June 14–19. Mitochondrion, 2005, 5/3:226–227

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Comenius University, Bratislava, Slovakia

    Jozef Čársky Ph.D.

  2. First Medical Clinic, Comenius University, Bratislava, Slovakia

    Miroslav Mikulecký M.D., Ph.D., D.Sc.

  3. Halberg Hospital and Research Institute, Moradabad, UP, India

    Ram B. Singh M.D.

Authors
  1. Jozef Čársky Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Associate professor Anna Gvozdjáková Ph.D., D.Sc.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Miroslav Mikulecký M.D., Ph.D., D.Sc.
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jarmila Kucharská Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ram B. Singh M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Comenius University, Bratislava, Slovakia

    Anna Gvozdjáková Ph.D., D.Sc.

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer Science + Business Media B.V

About this chapter

Cite this chapter

Čársky, J., Gvozdjáková, A., Mikulecký, M., Kucharská, J., Singh, R.B. (2008). Mitochondrial Diabetology. In: Gvozdjáková, A. (eds) Mitochondrial Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6714-3_8

Download citation

  • DOI: https://doi.org/10.1007/978-1-4020-6714-3_8

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-1-4020-6713-6

  • Online ISBN: 978-1-4020-6714-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation