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Other Model Organisms for Sarcomeric Muscle Diseases

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The Sarcomere and Skeletal Muscle Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 642))

Abstract

Model organisms are vital to our understanding of human muscle biology and disease. The potential of the nematode Caenorhabditis elegans, the fruitfly, Drosophila melanogaster and the zebrafish, Danio rerio, as model genetic organisms for the study of human muscle disease is discussed by examining their muscle biology, muscle genetics and development. The powerful genetic tools available with each organism are outlined. It is concluded that these organisms have already demonstrated potential in facilitating the study of muscle disease and in screening for therapeutic agents.

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Authors and Affiliations

  1. Department of Biology, University of York, York, Y010 5DD, UK

    John Sparrow

  2. Randall Division of Cell and Molecular Biophysics, King’s College London, London, UK

    Simon M. Hughes

  3. MRC Centre for Developmental Neurobiology, King’s College London, London, UK

    Simon M. Hughes

  4. Batiment Mendel, Universite Claude Bernard Lyon-1, Villeurbanne, France

    Laurent Segalat

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  1. John Sparrow
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  2. Simon M. Hughes
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  3. Laurent Segalat
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Correspondence to John Sparrow .

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Editors and Affiliations

  1. Centre for Medical Research, University of Western Australia, Western Australian Institute for Medical Research, Nedlands, Western Australia, Australia

    Nigel G. Laing PhD

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Sparrow, J., Hughes, S.M., Segalat, L. (2008). Other Model Organisms for Sarcomeric Muscle Diseases. In: Laing, N.G. (eds) The Sarcomere and Skeletal Muscle Disease. Advances in Experimental Medicine and Biology, vol 642. Springer, New York, NY. https://doi.org/10.1007/978-0-387-84847-1_14

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